排序方式: 共有12条查询结果,搜索用时 15 毫秒
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Elisabeth CW van Straaten Willem de Haan Hanneke de Waal Philip Scheltens Wiesje M van der Flier Frederik Barkhof Ted Koene Cornelis J Stam 《BMC neuroscience》2012,13(1):1-7
Background
This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague?CDawley rats were randomly allotted into 3 groups of ten animals each and received experimental diets with different n-6: n-3 PUFA ratios of either 65:1, 22:1 or 4.5:1. After 10?weeks, the spatial memory of the animals was assessed using the Morris Water Maze test. The expression of PPAR?? and PPAR?? genes were determined using real-time PCR.Results
Decreasing dietary n-6: n-3 PUFA ratios improved the cognitive performance of animals in the Morris water maze test along with the upregulation of PPAR?? and PPAR?? gene expression. The animals with the lowest dietary n-6: n-3 PUFA ratio presented the highest spatial learning improvement and PPAR gene expression.Conclusion
It can be concluded that modulation of n-6: n-3 PUFA ratios in the diet may lead to increased hippocampal PPAR gene expression and consequently improved spatial learning and memory in rats. 相似文献6.
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Poolman HR Boersma DJ Harvey M Higinbotham DW Passchier I Six E Alarcon R van Amersfoort PW Bauer TS Boer Rookhuizen H van Den Brand JF van Buuren LD Bulten HJ Ent R Ferro-Luzzi M Geurts DG Heimberg P de Jager CW Klimin P Koop I Kroes F van Der Laan J Luijckx G Lysenko A Militsyn B Nesterenko I 《Physical review letters》2000,84(17):3855-3858
We report on first measurements with polarized electrons stored in a medium-energy ring and with a polarized internal target. Polarized electrons were injected at 442 MeV (653 MeV), and a partial (full) Siberian snake was employed to preserve the polarization. Longitudinal polarization at the interaction point and polarization lifetime of the stored electrons were determined with laser backscattering. Spin observables were measured for electrodisintegration of polarized 3He, with simultaneous detection of scattered electrons, protons, neutrons, deuterons, and 3He nuclei, over a large phase space. 相似文献
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Bobeldijk I Bouwhuis M Ireland DG de Jager CW Jans E de Jonge N Kasdorp WJ Konijn J Lapikás L van Leeuwe JJ van der Meer RL Nooren GJ Passchier E Schroevers M van der Steenhoven G Steijger JJ Theunissen JA van Uden MA de Vries H de Vries R de Witt Huberts PK Blok HP van den Brink HB Dodge GE Harakeh MN Hesselink WH Kalantar-Nayestanaki N Pellegrino A Spaltro CM Templon JA Hicks RS Kelly JJ Marchand C 《Physical review letters》1994,73(20):2684-2687
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Ferro-Luzzi M Bouwhuis M Passchier E Zhou Z Alarcon R Anghinolfi M van Bommel R Botto T van den Brand JF Buchholz M Bulten HJ Choi S Comfort J Dolfini S Ent R Gaulard C Higinbotham D de Jager CW van Klaveren EP Konstantinov E Lang J de Lange DJ Miller MA Nikolenko D Nooren GJ Papadakis N Passchier I Poolman HR Popov SG Rachek I Ripani M Six E Steijger JJ Taiuti M Unal O Vodanis N de Vries H 《Physical review letters》1996,77(13):2630-2633