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Brunella Cappello Clelia Di Maio Maria Iervolino 《Journal of inclusion phenomena and macrocyclic chemistry》2002,43(3-4):251-257
The interactions of Bendazac, a topical non-steroidal anti-inflammatory drug, with-cyclodextrin, hydroxypropyl--cyclodextrin and -cyclodextrinwere investigated to evaluate possibilities to improve the drug's poor water solubilityand eventually to enhance the topical delivery of Bendazac. Phase solubility studiesdemonstrated the ability of the selected cyclodextrins to complex with Bendazac andincrease drug solubility. The amount of solubilized Bendazac increased linearly withthe addition of each cyclodextrin according toAL type plots. 13C-NMR studiesshowed that the Bendazac A-ring was included in the cavity of the three cyclodextrins.The -cyclodextrin was also able to include the B-ring of Bendazac, forminga complex where one drug molecule fitted into two cyclodextrin molecules. Equimolarsolid systems of the drug with each cyclodextrin carrier were prepared using varioustechniques (physical mixing, spray-drying and freeze-drying). The results of differential scanning calorimetry and Fourier transform infrared analysis, performed on the solid systems, demonstrated that freeze-dried and spray-dried products had a high degree of amorphization and agreed with the hypothesis of the existence of drug–cyclodextrin interaction in the solid state. The cyclodextrins tested were able to improve the dissolution of Bendazac. The dissolution profile of the drug was also affected by the physico-chemical properties of each solid system, the freeze-dried products being the most rapidly dissolving forms. 相似文献
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Angela Bonaccorso 《Acta Physica Hungarica A》2003,18(2-4):193-202
This article examines a number of reaction mechanisms for scattering initiated by an exotic projectile. Comparisons are made with recent experimental data, in order to extract information on the peculiarity of the nuclear structure under extreme conditions and to test the accuracy of the available theoretical methods. Predictions for future experiments are also made. 相似文献
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Lawrence P. Belluce Antonio Di Nola Brunella Gerla 《Applied Categorical Structures》2007,15(1-2):135-151
In this paper, after recounting the basic properties of perfect MV-algebras, we explore the role of such algebras in localization
issues. Further, we analyze some logics that are based on Łukasiewicz connectives and are complete with respect to linearly
ordered perfect MV-algebras.
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Marco Brunella 《Bulletin of the Brazilian Mathematical Society》1993,24(1):89-104
We show that any expansive flow on a 3-manifold which is a Seifert fibration or a torus bundle overS
1 is topologically equivalent to a transitive Anosov flow. This is achieved by analyzing the trace of the stable foliation (with singularities) of the flow on incompressible tori embedded in such a manifold. 相似文献
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