Nanostructured Colloidal Solutions of Malachite Green Formulated: Nonlinear Optical Properties and Simulation

Journal of Fluorescence - Malachite green (MG) is a dye that has been presented to use as photosensitizers for photodynamic therapy (PDT). Nonlinear absorption coefficient (β) and nonlinear...     

Filter-radiometer-based realization of candela and establishment of photometric scale at UME

The luminous intensity unit of candela was realized based on filter-radiometer, which is traceable to detector-based primary standard electrical substitution cryogenic radiometer (ESCR). In that realization the traditional Osram Wi41/G-type incandescent lamp and filter-radiometer consisting of an aperture, a V(λ) filter and a silicon photodiode based trap detector were used as light source and detection element, respectively. Measurement techniques of effective aperture area, spectral transmittance of V(λ) filter and absolute responsivity of trap detector are also presented.     

A generalization of Lomonosov's inequality and its applications to invariant subspaces

In this article we generalize Victor Lomonosov's famous inequality so as to be applicable to a wider class of functions. Then using it we prove that the adjoint of an algebra with a compactness property which is weaker than the PS property, employed by Victor Lomonosov, has nontrivial invariant subspaces.

     

Thermodynamic and lfer studies for the oxidation of anilines by the periodate ion

The various thermodynamic parameters for the periodate oxidation of six anilines, viz. aniline, p-chloroaniline, p-ethoxyaniline, o- and p-methoxyanilines and p-methylaniline have been reported and discussed. The validity of the isokinetic relationship and various linear free energy relationships (LFERs) have been tested and discussed. An attempt has been made to correlate these findings with the mechanism operative in these reactions.     

The facile and efficient Michael addition of indoles and pyrrole to alpha,beta-unsaturated electron-deficient compounds catalyzed by aluminium dodecyl sulfate trihydrate [Al(DS)3].3H2O in water

Aluminium dodecyl sulfate trihydrate [Al(DS)3].3H2O is easily prepared and can be used as a Lewis acid surfactant catalyst in water to conduct the highly efficient Michael addition of indoles and pyrrole to alpha,beta-unsaturated electron-deficient compounds at room temperature.     

Synthesis of 11C-amides using [11C]carbon monoxide and in situ activated amines by palladium-mediated carboxaminations

[11C]Carbon monoxide at low concentrations, aryl halides and amines were used in the palladium-mediated synthesis of twenty 11C-amides. In the study several approaches to improve the radiochemical yield were explored. Eight of the selected amides were prepared by in situ activation of the amines using lithium bis(trimethylsilyl)amide and the radiochemical yields of these reactions were improved compared to utilising a previous reported method. In the synthesis of 1-[carbonyl-11C]benzoyl-3-methyl-1H-indole (11) from 3-methyl-1H-indole (25), the corresponding organotin-amine was prepared prior to the acylation reaction. In a typical experiment, N-(4-hydroxyphenyl)[carbonyl-11C]acetamide (5) was prepared in 15% radiochemical yield using 4-aminophenol (20) but the yield increased to 63% when the amine was activated by lithium bis(trimethylsilyl)amide.     

Toward artificial developmental regulators

A polyamide-peptide conjugate is designed which recruits sequence specifically the developmental regulator Exd to a cognate DNA site. In particular, an eight-ring hairpin polyamide (Im-Im-Py(C3H6NHR)-Py-gamma-Im-Py-Py-Py-beta-Dp) with a heptapeptide (R = Ac-Phe-Tyr-Pro-Trp-Met-Lys-Gly-) attached on a central ring was shown to induce cooperative binding of the Drosophila Hox protein cofactor Exd with a Kd of 4.4 nM in vitro, an order of magnitude more efficient than the natural Hox protein partner Ubx. The conjugate joins two sequence specific domains, one for DNA and one for the protein. This small molecule thus serves as a cooperative protein-DNA dimerizer, which mimics the natural Hox family of developmental regulators.