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DNA拓扑异构酶是一种广泛存在于真核细胞和原核细胞中的重要生物酶,对DNA转录、复制、染色体分离及基因表达等过程中的DNA拓扑结构起着重要的调控作用。研究发现,与正常细胞不同,DNA拓扑异构酶在肿瘤细胞中表现出不受其他因素影响的高水平表达,而许多抗肿瘤药物的作用机制也与DNA拓扑异构酶密切相关,因此它作为抗肿瘤药物的重要靶点引起了研究者的广泛关注。本文对DNA拓扑异构酶的结构、分类及生物功能进行了简要的归纳,总结了近年来DNA拓扑异构酶抑制剂的研究进展,并重点对金属配合物作为DNA拓扑异构酶抑制剂的研究现状进行了详细的介绍。 相似文献
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The fatigue problem in ferroelectric thin films is investigated based on the switched charge per unit area versus switching cycles.The temperature,dielectric permittivity,voltage bias,frequency and defect valence dependent switching polarization properties are calculated quantitatively with an extended Dawber-Scott model.The results are in agreement with the recent experiments. 相似文献
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采用甚高频增强型等离子体化学气相沉积技术,通过优化薄膜的沉积条件制备出高性能的P nc Si∶H薄膜材料(σ=5.86 S/cm、Eopt>2.0 eV).通过XRD测量计算出薄膜<111>、<220>和<311>三个晶向上的晶粒大小分别为15 nm、17 nm和21 nm;通过Raman测量,计算出其晶化率为35%左右.实验中,将P型纳米硅薄膜与氧化铟锡一起构成有机电致发光器件的复合阳极,研究了他们的发光特性,结果表明:由于P nc Si∶H薄膜材料具有近似半反半透的光学特性,它与高反射率的阴极Al使有机电致发光器件产生了微腔效应,使其发光光谱窄化,半宽高由126 nm窄化到33 nm;发光光亮明显增强,最大亮度为47 130 cd/m2,最大发光效率为9.543 83 cd/A,与以ITO为阴极的无腔器件相比,提高了约127%. 相似文献
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CONCISE POLARON MODEL TO THE CALCULATION OF BINDING ENERGY IN SOME STRONG-AND WEAK-COUPLING POLAR CRYSTALS 下载免费PDF全文
A new concise polaron model is proposed to study the ground state of polarons in some strong-and weak-coupling polar crystals. The ground state energy and binding energy of these materials are calculated numerically by iteration method. Results are in close agreement with the experimental data. 相似文献
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采用射频磁控溅射法,在不同的Ar∶O2条件下,以高掺磷n型Si衬底为磷掺杂源制备了p型ZnO薄膜和p-ZnO/n-Si异质结.对ZnO∶P薄膜进行了光致发光谱(PL)、霍尔参数、Ⅰ-Ⅴ特性、扫描电镜(SEM)和X射线衍射谱(XRD)等测试.结果表明,获得的ZnO∶P薄膜沿(0002)晶面高取向生长,以3.33 eV近带边紫外发光为主,伴有2.69 eV附近的深能级绿色发光峰,空穴浓度为8.982 × 1017/cm3,空穴迁移率为9.595 cm2/V·s,p-ZnO/n-Si异质结I-V整流特性明显,表明ZnO∶P薄膜具有p型导电特性. 相似文献
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The variational method is applied to the study of charge
transfer in dry DNA by using an extended Holstein small polaron
model in two cases: the site-dependent finite-chain discrete
case and the site-independent continuous one. The treatments in the two cases
are proven to be consistent in theory and calculation. Discrete
and continuous treatments of Holstein model both can yield a
nonlinear equation to describe the charge migration in an actual
long-range DNA chain. Our theoretical results of binding energy
Eb, probability amplitude of charge carrier \phi and the
relation between energy and charge--lattice coupling strength are
in accordance with the available experimental results and recent
theoretical calculations. 相似文献
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Using 1+1 soliton-like polaron model of a deformable continuum, the critical temperature and the energy gap in high-temperature superconductors Y1-xCaxBa2Cu3-xMxO7-δ(M=Fe,Ni) are studied in the framework of finite temperature Green's function theory. The ratio 2Δ/kBTc=3.9 is obtained. Theoretical results are found in good agreement with the experimental data. 相似文献