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Viktor Zvarych Maryna Stasevych Eduard Rusanov Mykhailo Vovk 《Molecules (Basel, Switzerland)》2022,27(18)
The [1,2,3]triazin-4(3H)-one ring is a synthetically important molecular platform for a variety of chemical transformations. Despite this, currently, there has been little research on the reaction of the thermal opening of the [1,2,3]triazin-4(3H)-one nucleus. In this work, we describe the synthetic potential of anthra[1,2-d][1,2,3]triazine-4,7,12(3H)-trione in the reaction of the thermal opening of a cycle following the [4+2]-cycloaddition reaction with a number of pyridine derivatives and quinoline. It is shown that this method is effective for the synthesis of the 6H-naphtho[2,3-H]pyrido(quinolino)[2,1-b]quinazoline-6,9,14-trione system. We also investigate the influence of the position of substituents in the structure of pyridine on the formation characteristics of the target products. 相似文献
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M. Stasevych V. Zvarych V. Lunin N. G. Deniz Z. Gokmen O. Akgun 《SAR and QSAR in environmental research》2017,28(5):355-366
Anticancer activity as an associated action for a series of dithiocarbamates of 9,10-anthracenedione was predicted using the PASS computer program and analysed with PharmaExpert software. The predicted cytotoxic activity of the dithiocarbamate derivatives of 9,10-anthracenedione was evaluated in vitro on cancer cells of the human lung (A549), prostate (PC3), colon (HT29) and human breast (MCF7) using the sulforhodamine B (SRB) cell viability assay. Among these compounds, 9,10-dioxo-9,10-dihydroanthracen-1-yl pyrrolidin-1-carbodithioate and 9,10-dioxo-9,10-dihydroanthracen-2-yl pyrrolidin-1-carbodithioate were identified as the most potent anticancer agents with cytotoxic activity against the MCF-7 human breast cell line with GI50 values of 1.40 μM and 1.52 μM, whereas the GI50 value for the reference anticancer drug mitoxantrone was 3.93 μM. Thus, anticancer activity predicted by PASS with a probability Pa > 30% was confirmed by the experiment. Relatively small Pa values estimated by PASS indicated the novelty of the considered derivatives comparing to the compounds from the PASS training set. 相似文献
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Stasevych M. V. Zvarych V. I. Lunin V. V. Kopak N. A. Novikov V. P. Chernobaev I. I. Vovk M. V. 《Russian Journal of General Chemistry》2018,88(4):836-838
Russian Journal of General Chemistry - 9,10-Dioxoanthracenyl-1(2)-diazonium hydrosulfates reacted with pyridine under both the modified Gomberg–Bachmann reaction conditions and in the... 相似文献
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Stasevych M. V. Zvarych V. I. Lunin V. V. Vovk M. V. Novikov V. P. 《Russian Journal of Organic Chemistry》2017,53(3):468-469
Russian Journal of Organic Chemistry - An efficient procedure has been proposed for the synthesis of previously unknown 1-hydrazinylanthraquinones containing acyl and/or ester fragments convenient... 相似文献
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