An immersed smoothed point interpolation method (IS‐PIM) for fluid‐structure interaction problems

An immersed smoothed point interpolation method using 3‐node triangular background cells is proposed to solve 2D fluid‐structure interaction problems for solids with large deformation/displacement placed in incompressible viscous fluid. In the framework of immersed‐type method, the governing equations can be decomposed into 3 parts on the basis of the fictitious fluid assumption. The incompressible Navier‐Stokes equations are solved using the semi‐implicit characteristic‐based split scheme, and solids are simulated using the newly developed edge‐based smoothed point interpolation method. The fictitious fluid domain can be used to calculate the coupling force. The numerical results show that immersed smoothed point interpolation method can avoid remeshing for moving solid based on immersed operation and simulate the contact phenomenon without an additional treatment between the solid and the fluid boundary. The influence from information transfer between solid domain and fluid domain on fluid‐structure interaction problems has been investigated. The numerical results show that the proposed interpolation schemes will generally improve the accuracy for simulating both fluid flows and solid structures.     

介绍一个化学工程与分析化学相结合的综合化学实验——超滤回收聚乙二醇

介绍超滤回收溶液中聚乙二醇的实验。采用Dragendorff试剂方法测定聚乙二醇浓度和截留率,研究操作条件对渗透速率的影响,探讨膜污染机理以及清洗方法,并根据实验中发现的问题,改进了Dragendorff测定方法。     

Catalytic intermolecular C-alkylation of 1,2-diketones with simple olefins: a recyclable directing group strategy

We describe the first example of Rh-catalyzed intermolecular C-alkylation of cyclic 1,2-diketones using simple terminal olefins as alkylating agents. Aminopyridine is employed as a recyclable directing group. First, it reacts with ketones to give enamines and delivers Rh to activate the vinyl C-H bonds in the same pot; second, it can be cleaved off and recovered via hydrolysis. A broad range of olefins can be utilized as substrates, including aliphatic, aromatic olefins and vinyl esters. The efficiency of this method is also demonstrated in the synthesis of a natural flavoring compound, 3-ethyl-5-methyl-1,2-cyclopentadione (one-pot 53% yield vs a previous four-step route 16% yield from the same starting material). This work is expected to serve as a seminal study toward catalytic ketone α-alkylation with unactivated olefins.     

Morphological evolution of Ge islands on the Si(100) surface: from huts to pits

The morphological evolution on the size and shape of Ge island on the Si(100) surface by depositing and subsequent annealing processes is studied in situ by using scanning tunneling microscopy at ultrahigh vacuum environment. A slower growth rate is maintained when the islands grow to larger sizes beyond the wetting layers. While at room temperature, the epitaxial strain is relieved by the formation of three‐dimensional islands (so‐called ‘hut’ clusters). When the sample is annealed at 200 °C, the strain is relieved by forming pits, having the circular cone shape but with their apex pointing down, with Ge clusters formed at the rim of pits. Copyright © 2016 John Wiley & Sons, Ltd.     

Far‐Red and Near‐IR AIE‐Active Fluorescent Organic Nanoprobes with Enhanced Tumor‐Targeting Efficacy: Shape‐Specific Effects

The rational design of high‐performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation‐induced emission (AIE)‐active organic molecules to realize preferable far‐red and NIR fluorescence, well‐controlled morphology (from rod‐like to spherical), and also tumor‐targeted bioimaging. The shape‐tailored organic quinoline–malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell‐tracking applications. Impressively, the spherical shape of QM‐5 nanoaggregates exhibits excellent tumor‐targeted bioimaging performance after intravenously injection into mice, but not the rod‐like aggregates of QM‐2.     

时滞对结构振动半主动控制效果的影响

应用磁流变阻尼器对结构振动进行控制，采用最优控制原理设计了控制器，给出在地震激励下结构半主动控制的仿真计算。研究了时滞对结构振动半主动控制效果的影响。数值结果表明：本文设计的半主动控制策略可有效地减小结构的振动响应，时滞对磁流变半主动控制效果随着时滞的增大而变差，但时滞不会导致该反馈控制系统的失稳。     

Preclinical pharmacokinetics comparison between resveratrol 2-hydroxypropyl-β-cyclodextrin complex and resveratrol suspension after oral administration

Trans-Resveratrol (RV) is a natural polyphenol characterized by interesting pleiotropic potentials and health benefits, but its administration is hampered by a unsatisfactory pharmacokinetics. Various approaches have been identified to circumvent it: among them, 2-hydroxypropyl-β-cyclodextrins (HPβCD) are valuable strategy. Here, we compare the employment of HPβCD based formulation with a resveratrol nanosupension (obtained by diluting a RV ethanol solution with PBS, added of 0.05 % hydroxyethylcellulose) to improve RV bioavailability after oral administration to mice. The inclusion of RV in HPβCD was confirmed by differential scanning calorimetry, Fourier transformed infrared spectroscopy, and phase solubility study. The two formulations were orally administered to BALB-c mice. RV concentrations in plasma and tissues were detected at different time (0–120 min) by HPLC method. HPβCD complexation mediate a approximately fourfold increment in plasma RV C_max and  approximately twofold augment of RV AUC_0-120 in comparison with RV nanosuspension. Similar increased concentrations were observed in heart, liver, kidney and gut. In particular, HPβCD mediated a 5.5-folds increase of resveratrol concentration in the intestine, in comparison to the nanosuspension. In conclusion, based on our results, HPβCD complexation is a promising approach to increase the oral bioavailability of RV. Moreover, the achievement of high concentrations in gut suggested a potential employment of oral RV-HPβCD as anti-inflammatory/chemopreventive agent in this tissue.