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Inhibition of Metalloproteinase Activity by Chinese Formulations Used to Treat Inflammatory Diseases
JIN Feng-hai WANG Hui-ling ZHAO Shu-hua YANG Jin-gang FANG Xue-xun 《高等学校化学研究》2006,22(2):245-247
Introduction Matrixmetalloproteinases(MMPs)areaclassof zinc requiringextracellularendopeptidasesthatcanto getherdegradeallcomponentsoftheextracellularma trixandbasementmembranes[1—3].Theyplayimpor tantrolesinconnectivetissueremodeling,occurringin normalb… 相似文献
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YUAN Hao YANG Jin-gang WANG Zhong-yuan ZHAO Shu-hua YU Da-hai FANG Xue-xun . Key Laboratory of Molecular Enzymology Engineering Ministry of Education College of Life Science Jilin University Changchun P. R. China 《高等学校化学研究》2011,(2):269-272
We reported that Catechu extract has a significant inhibitory effect on cathepsin B activity. The IC50 value for the Catechu extract against cathepsin B was 7.6 μg/mL. In addition, we showed that HT1080 human fibrosarcoma cells express cathepsin B and Catechu modulate the invasion and motility of these cells. These data may provide molecular mechanisms for the therapeutic effects of Catechu. 相似文献
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SHI Xiu-juan JIN Feng-hai WANG Hui-ling YANG Jin-gang WANG Zhi-yong FANG Xue-xun 《高等学校化学研究》2006,22(2):129-133
Introduction Matrixmetalloproteinases(MMPs)areafamilyof calciumandzincrequiringendoproteinasesthattogether candegradeallthemaincomponentsoftheextra cellu larmatrixandbasementmembranes[1].MMPsarein volvedinawiderangeofproteolyticevents,innormal andpatholog… 相似文献
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Operons, or co-transcribed and co-regulated contiguous sets of genes, in microbial genomes are poorly conserved across different genomes due to gene fusion, deletion, duplication and other genome shuffling processes. The currently available genomes are the results of numerous reshuffling and acceptance iterations. We hypothesized that in ancient times, when life was more primitive, functionally related genes existed in close proximity and operated together as an operon to simplify regulation. As more sophisticated regulation mechanisms became available during evolution the genes forming an operon could be separated by the above mentioned processes. If gene shuffling is a random event, neighbor gene pairs are more likely to be preserved than distant gene pairs. Thus, if enough gene pairs can be identified, the original operon could be reconstructed by assembling the pairs. Here we propose a novel paleogenomic method to reconstruct present neighbor gene pairs into "ancient" operons that possibly existed at some point during evolution. 相似文献
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ZHANG Jin-liang GUO Yang-hong GAO Chao-hui WANG En-si REN Zhong-yuan FANG Xue-xun WANG Ji-dong 《高等学校化学研究》2010,26(2):256-258
4,5-Dihydro-3-methylbenzo[1,2-b]furan-4,5-dione(4) was identified as a novel and potent inhibitor of caspase-3 through structural modification of an existing drug,sodium tanshinone ⅡA sulfonate(STS).Compound 4 showed high potency against caspase-3 in vitro(IC50=0.13 μmol/L).Molecular docking study further provided an insight into the interaction of compound 4 with activated caspase-3.Hence,this small-molecule caspase-3 inhibitor could be a promising therapeutic candidate against diseases caused by abnormally up-regulated apoptosis. 相似文献
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LIU Jun-song. YANG Jin-gang HONG Yuan JIN Feng-hai WANG Ming-cui ZHAO Shu-hua FANG Xue-xun . Key Laboratory of Molecular Enzymology Enzyme Engineering of Ministry of Education Jilin University Changchun P. R. China . College of Life Science Changchun . College of Medicine 《高等学校化学研究》2009,25(2)
Matrix metalloproteinases(MMPs) play an essential role in development and tissue remodeling of living organisms.However,the overexpression of MMPs has lead to a series of diseases,such as cancer,arthritis,and atherosclerosis;and inhibition of MMPs may have therapeutic benefits.The discovery of MMP inhibitors from herbal has become a prospective event.We showed that the extract of Polygoni multiflori caulis from ethy1 acetate or water(ethy1 acetate extract and water extract) can inhibit the activities of MMPs 9,14,and 16 in a dose-dependent manner and n-buty1 alcohol extract of it can also inhibit these MMPs.Furthermore,we found that n-buty1 alcohol extract and water extract of it influence the cell viability.These discoveries may contribute to the development of MMP inhibitors for the therapy of a variety of pathological conditions. 相似文献
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