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Olha Мykhailenko Sergiy Chetvernya Ivan Bezruk Yrii Buydin Nadija Dhurenko Olena Рalamarchuk Liudas Ivanauskas Victoriya Georgiyants 《Biomedical chromatography : BMC》2022,36(7):e5369
Iris genus plants are a valuable source of bioactive compounds, which are an important component for pharmaceutical development. The present article shows the potential for mineral nutrition with application of magnesium sulfate, iron chelates and potassium oxide affecting the phenolic compound contents in Iris hybrida ‘Tsikavynka’, I. hybrida ‘Tambo’ and I. hybridа ‘Widecombe Fire’. The effect of mineral processing was specific to plant organs and varied in the component composition. The Iris rhizomes had an increased total phenolic compound content after treatment (up to 10% of the total isoflavonoid content, up to 8% of phenolic acids, up to 5% of γ-pyrones and up to 13% of flavonoids), determined using UV–vis spectroscopy. A positive effect of nutrition on the biosynthesis and content of individual isoflavonoids (tectoridin, nigricin d -glucoside, genistin, iristectorigenin B, nigricin, irigenin and irisolidone) and xanthone mangiferin in Iris rhizomes by HPLC was established. In addition, an increase in the chlorogenic acid amount in Iris leaves was noted. The results demonstrate the sensitivity of Iris phenylpropanoid metabolism to mineral nutrition and can be used to predict medical plant cultivation with increased content of bioactive constituents. 相似文献
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Bezuglyi P. A. Georgiyants V. A. Perekhoda L. A. Garnaya N. V. Sych I. A. 《Russian Journal of Organic Chemistry》2003,39(4):475-477
By condensation of symmetrical malonic acid diamides with dichloromethane (method a) and with paraform (method b) N,N',N',N'-substituted amides of 1,1,3,3-propanetetracarboxylic acid were synthesized. Better yields of the target products (68-80%) and the use of less toxic reagents indicate that method b is more feasible. The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity. 相似文献
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Rounova Olga Demin Peter Korotkov Mikhail Malkova Victoriya Ustinnikova Olga 《Analytical and bioanalytical chemistry》2018,410(26):6935-6942
Analytical and Bioanalytical Chemistry - In the study presented, a simple analytical method for the direct determination of glycine in immunoglobulins by hydrophilic interaction liquid... 相似文献
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Yuliya Prokopenko Valdas Jakštas Vaidotas Žvikas Victoriya Georgiyants Liudas Ivanauskas 《Natural product research》2019,33(13):1961-1963
The aim of research was to study the content of amino acids using in extracts of Fumaria schleicheri L., Ocimum basilicum L., and Corylus avellana L. by HILIC MS/MS method. Separation of amino acids in the samples was carried out with Acquity H-class UPLC system (Waters, Milford, USA) equipped with SeQuant ZIC-Hilic collumn (2.1 × 150 mm, 3.5 μm) (Merck Millipore, Darmstadt, Germany). The MS/MS fragment ion chromatograms of the test solutions established the presence of 19 amino acids. The obtained results have shown that O. basilicum L. characterized the highest concentrations of different neurogenic amino acids (128.1 mg/kg), comparing with F. schleicheri L. and C. avellana L. (57.72 and 52.91 mg/kg, respectively). 相似文献
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I. V. Ukrainets P. A. Bezuglyi O. V. Gorokhova V. I. Treskach V. A. Georgiyants A. V. Turov I. L. Dikii 《Chemistry of Heterocyclic Compounds》1993,29(1):87-91
We suggest a preparative method for the synthesis of dialkylaminoalkylamides of 4-hydroxy-2-quinolone-3-carboxylic acids, their hydrochlorides, and haloalkylates. We developed a simple and effective means of obtaining the halopropylamides of the indicated acids. Data on biological studies of the synthesized compounds is provided.For Communication 5, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 100–104, January, 1993. 相似文献
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Konovalova Irina S. Muzyka Ekaterina N. Urzhuntseva Victoriya V. Shishkina Svitlana V. 《Structural chemistry》2021,32(1):235-257
Structural Chemistry - The regularities of crystal structure organization in a series of mono- and diaminopyridines possessing biological activities were studied using an approach based on... 相似文献
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Olha Mykhailenko Vilma Petrikaite Michal Korinek Fang-Rong Chang Mohamed El-Shazly Chia-Hung Yen Ivan Bezruk Bing-Hung Chen Chung-Fan Hsieh Dmytro Lytkin Liudas Ivanauskas Victoriya Georgiyants Tsong-Long Hwang 《Molecules (Basel, Switzerland)》2022,27(1)
Crocus sativus L. (saffron) has been traditionally used as a food coloring or flavoring agent, but recent research has shown its potent pharmacological activity to tackle several health-related conditions. Crocus sp. leaves, and petals are the by-products of saffron production and are not usually used in the medicine or food industries. The present study was designed to determine the chemical composition of the water and ethanolic extracts of C. sativus leaves and test their cytotoxic activity against melanoma (IGR39) and triple-negative breast cancer (MDA-MB-231) cell lines by MTT assay. We also determined their anti-allergic, anti-inflammatory, and anti-viral activities. HPLC fingerprint analysis showed the presence of 16 compounds, including hydroxycinnamic acids, xanthones, flavonoids, and isoflavonoids, which could contribute to the extracts’ biological activities. For the first time, compounds such as tectoridin, iristectorigenin B, nigricin, and irigenin were identified in Crocus leaf extracts. The results showed that mangiferin (up to 2 mg/g dry weight) and isoorientin (8.5 mg/g dry weight) were the major active ingredients in the leaf extracts. The ethanolic extract reduced the viability of IGR39 and MDA-MB-231 cancer cells with EC50 = 410 ± 100 and 330 ± 40 µg/mL, respectively. It was more active than the aqueous extract. Kaempferol and quercetin were identified as the most active compounds. Our results showed that Crocus leaves contain secondary metabolites with potent cytotoxic and antioxidant activities. 相似文献
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Laurynas Jarukas Konradas Vitkevicius Olha Mykhailenko Ivan Bezruk Victoriya Georgiyants Liudas Ivanauskas 《Molecules (Basel, Switzerland)》2022,27(13)
Saffron is widely cultivated and used as a spice. Recently published data on the chemical composition and pharmacological potential of saffron determine its use in pharmacy and medicine. The proposed high-performance thin-layer chromatography (HPTLC) method allows good separation of 11 analytes. The saffron quality (Iran, Ukraine, Spain, Morocco samples) assessment was based on the European Pharmacopoeia monograph and ISO 3632. The HPTLC method for the safranal, crocin, and picrocrocin quantification was proposed and validated. The crocins content in Ukrainian saffron was from 17.80% to 33.25%. Based on qualitative and quantitative assessment results, the saffron sample from Zaporizhzhia (Ukraine) had the highest compounds content and was chosen to obtain the working standards of picrocrocin and crocins (trans-4GG, trans-2G, trans-3Gg) by preparative chromatography. The compounds were isolated from lyophilized extract of saffron using a Symmetry Prep C18 column (300 × 19 mm × 7 µm), and identified by spectroscopic techniques (HPLC-DAD, UPLC-ESI-MS/MS). The purity of crocins and picrocrocin was more than 97%. A novel method proposed to obtain working standards is simple and reproducible for the routine analysis of saffron quality control. 相似文献