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Optimization of Lactic Acid Production by Pellet-Form Rhizopus oryzae in 3-L Airlift Bioreactor Using Response Surface Methodology 总被引:1,自引:0,他引:1
Thanapoom Maneeboon Wirat Vanichsriratana Chaiyaporn Pomchaitaward Vichien Kitpreechavanich 《Applied biochemistry and biotechnology》2010,161(1-8):137-146
The influence of two key environmental factors, pH and oxygen transfer coefficient (k La), was evaluated on the lactic acid production as the main answer and, on the size of cell pellets of the fungal strain Rhizopus oryzae KPS106, as second dependant answer by response surface methodology using a central composite design. The results of the analysis of variance and modeling demonstrated that pH and k La had a significant effect on lactic acid production by this strain. However, no interaction was observed between these two experimental factors. pH and k La had no significant influence on the pellet size. Optimal pH and k La of the fermentation medium for lactic acid production from response surface analysis was 5.85 and of 3.6 h?1, respectively. The predicted and experimental lactic acid maximal values were 75.4 and 72.0 g/l, respectively, with pellets of an average of 2.54?±?0.41 mm. Five repeated batches in series were conducted with a mean lactic acid production of 77.54 g/l. The productivity was increased from 0.75 in the first batch to 0.99 g/l h in the last fifth batch. 相似文献
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Thammanoon Sreethawong Thanapoom Suwannabart Sumaeth Chavadej 《Plasma Chemistry and Plasma Processing》2008,28(5):629-642
Ethylene oxide (EO), a valuable chemical feedstock in producing many industrial chemicals, which is industrially produced
by the partial oxidation of ethylene, so-called ethylene epoxidation, has been of great interest in many global research studies.
In this work, the epoxidation of ethylene under a low-temperature dielectric barrier discharge (DBD) was feasibly investigated
to find the best operating conditions. It was experimentally found that the EO yield decreased with increasing O2/C2H4 feed molar ratio, feed flow rate, input frequency, and electrode gap distance, while it increased with increasing applied
voltage up to 19 kV. The highest EO yield of 5.6% was obtained when an input frequency of 500 Hz and an applied voltage of
19 kV were used, with an O2/C2H4 feed molar ratio of 1:1, a feed flow rate of 50 cm3/min, and an electrode gap distance of 10 mm. Under these best conditions, the power consumption was found to be as low as
6.07 × 10−16 Ws/molecule of EO produced. 相似文献
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