Synthesis and biological properties of novel structural analogs of isothiobarbamine

Russian Chemical Bulletin - Novel structural analogs of isothiobarbamine, which differ from the prototype scaffold by the substituent at position 2 of the pyrimidine heterocycle, were for the first...     

Aminolysis of 6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methyl-2-(nitroamino)pyrimidin-4(3<Emphasis Type="Italic">H</Emphasis>)-one

The aminolysis of 6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methyl-2-(nitroamino)pyrimidin-4(3H)-one with various amines in butan-1-ol and under solvent-free conditions is successful when the amino group in the reagent is sterically unshielded and the reaction medium is characterized by a high dielectric permittivity. Reactions of the title compound with sterically shielded amines are accompanied by alcoholysis where the amine acts as a base catalyst.     

Synthesis and cytotoxic activity of Boc-protected pentapeptide amide analogs of somatostatin

Russian Chemical Bulletin - New Boc-protected pentapeptide amides of the general formula Boc—Cys(Boc)—Phe—d-Trp—Lys(Boc)—Thr—NHR, which are analogs of the...     

Some Features of the Tscherniac‒Einhorn Reaction with 2-Thiouracil Derivatives

The Tscherniac–Einhorn reaction of 6-methyl and 6-(trifluoromethyl) derivatives of 2-thiouracil with N-(bromomethyl)phthalimide in under basic catalysis leads to the formation of S-amidomethylation products. When using 6-amino-2-thiouracil, decomposition of the alkylation products occurs. An in vitro study of the compounds obtained showed their lack of cytotoxicity and anti-HIV-1/2 activity.     

Sensitivity to hydrogen of sensor materials based on SnO2 promoted with 3d metals

The sensitivity to hydrogen and the catalytic activity in the oxidation of hydrogen of sensor materials based on tin dioxide and doped with cobalt, nickel, iron, and copper have been studied. The sensitivity of the sensors and the degree of conversion of hydrogen pass symbatically through a maximum with increasing quantity of each of the dopants. The results are explained by the influence of grain boundaries between tin dioxide and the dopants applied during the course of the oxidation reaction of hydrogen on the sensor material and on the sensitivity of the sensor to H₂. __________ Translated from Teoreticheskaya i éksperimental’naya Khimiya, Vol. 44, No. 2, pp. 121–125, March–April, 2008.     

Pentapeptide analogs of somatostatin containing a thiazolidine fragment: synthesis and cytotoxic activity

Russian Chemical Bulletin - Pentapeptide analogs of somatostatin containing an (R)-1,3-thiazolidine fragment (Thz) of the general formula...     

Effect of SnO2 particle size on the hydrogen sensitivity of adsorption–semiconductor sensors with CoxOy/SnO2 active coating

The effect of cobalt additions on the electrical resistance of adsorption–semiconductor sensors based on nanosized SnO₂ in air, their sensitivity to hydrogen, and the catalytic activity of the corresponding sensor materials in the oxidation of H₂ were studied. The extremal nature of the obtained relationships is explained by morphological features of the investigated systems based on nanosized SnO₂.     

Optimization of Antenna Current Feeding for the Alfvén Eigenmodes Active Diagnostic System of JET

The possibility of exploring proper phasing of the feeding currents in the existing antenna of the Alfvén Eigenmodes Active Diagnostic system of JET, to excite pure toroidal spectra of Toroidal Alfvén Eigenmodes, is numerically investigated. Special attention is given to the actual perturbed fields excited in the plasma, which are calculated self-consistently using the antenna version of the CASTOR code. It is found that due to the close spacing of the JET antenna modules and quasi degeneracy of modes with medium to high values of the toroidal mode number n, although a proper choice of the phasing of the feeding currents of the antenna modules indeed leads to an increase of the perturbed fields of the selected mode, modes with nearby values of n are also excited with large amplitudes, so that a scheme to proper select the detected modes remains necessary. A scheme using different antenna position distribution is proposed to achieve successful optimization.     

Reactions of indolylmagnesium bromide with trans-2-phenylcyclopropane-1-carbonyl chloride

Russian Journal of General Chemistry -