Form I of desloratadine,a tricyclic anti­histamine

The title compound [systematic name: 8‐chloro‐11‐(piperidin‐4‐yl­idene)‐6,11‐dihydro‐5H‐benzo[4,5]cyclo­hepta­[2,1‐b]pyridine], C₁₉H₁₉ClN₂, was crystallized from ethyl acetate. The inter­esting feature of the reported structure is that it does not contain any strong hydrogen bonds, although the mol­ecule contains a secondary NH group, which is a good hydrogen‐bond donor.     

Rapid and efficient synthesis of optically active pyrazoles under solvent-free conditions

2-Formyl glycals undergo rapid condensation with arylhydrazines under solvent-free conditions to give the corresponding optically pure 4-substituted pyrazoles in good yields with high selectivity. The stereochemistry of the products was assigned by various NMR experiments.     

Vanadium(III) chloride catalyzed Biginelli condensation: solution phase library generation of dihydropyrimidin-(2H)-ones

The three component condensation of an aldehyde, a β-keto ester and urea (thiourea) in the presence of a catalytic amount of VCl₃ is disclosed for the solution phase synthesis of dihydropyrimidinones. The ease of synthesis and work-up allowed the parallel synthesis of a 48-membered library of dihydropyrimidinones quickly and efficiently in good yields.     

Friedel-Crafts alkylation of indoles with epoxides catalyzed by nanocrystalline titanium(IV) oxide

Friedel-Crafts alkylation of indoles with epoxides to afford 3-alkyl indole derivatives at room temperature with moderate to good yields and high regioselectivity using nanocrystalline titanium(IV) oxide catalyst is described.     

Study of solar features causing GMSs with 250γ<<Emphasis Type="Italic">H</Emphasis><400γ

The effect of solar features on geospheric conditions leading to geomagnetic storms (GMSs) with planetary index,A ^P ≥ 20 and the range of horizontal component of the Earth’s magnetic fieldH such that 250γ <H < 400γ has been investigated using interplanetary magnetic field (IMF), solar wind plasma (SWP) and solar geophysical data (SGD) during the period 1978–99. Statistically, it is observed that maximum number of GMSs have occurred during the maximum solar activity years of 21st and 22nd solar cycles. A peculiar result has been observed during the years 1982, 1994 when sunspot numbers (SSNs) decrease very rapidly while numbers of GMSs increase. No distinct association between yearly occurrence of disturbed days and SSNs is observed. Maximum number of disturbed days have occurred during spring and rainy seasons showing a seasonal variation of disturbed days. No significant correlation between magnitude (intensity) of GMSs and importance ofH _α , X-ray solar flares has been observed. Maximum number of GMSs is associated with solar flares of lower importance, i.e., SF during the period 1978-93.H _α , X-ray solar flares occurred within lower helio-latitudes, i.e., (0–30)°N to (0–30)°S are associated with GMSs. NoH _α , X-ray solar flares have occurred beyond 40°N or 40°S in association with GMSs. In helio-latitude range (10–40)°N to (10–40)°S, the 89.5% concentration of active prominences and disappearing filaments (APDFs) are associated with GMSs. Maximum number of GMSs are associated with solar flares. Coronal mass ejections (CMEs) are related with eruptive prominences, solar flares, type IV radio burst and they occur at low helio-latitude. It is observed that CMEs related GMS events are not always associated with high speed solar wind streams (HSSWSs). In many individual events, the travel time between the explosion on the Sun and maximum activity lies between 58 and 118 h causing GMSs at the Earth.     

Role of orientation in kinetics of nucleation and growth of crystals in polymers

A theoretical framework is provided for generalizing the inferences drawn from the results of earlier experimental studies of kinetics of crystallization in oriented poly(ethylene terephthalate). The framework is obtained by combining extensions of classical nucleation theories in polymers^3,4 and a theory of crystal growth with anisotropic incorporation of segments into growing crystals.¹⁵ It is shown that, while a very strong dependence of rate of primary nucleation on orientation does exist, there is a only a much weaker dependence of rate of crystal growth on the orientation of the crystallizing polymer. The theoretical formulation provided here would allow qualitative estimates for comparison with experiments.     

Optimization of the process variables for the synthesis of cardanol-based novolac-type phenolic resin using response surface methodology

Models capable of predicting the maximum extent of conversion (p) of cardanol-based novolac-type phenolic resin, have been developed using response surface methodology to determine the optimum reaction conditions. Three-dimensional response surface and their contour plot were drawn. The maximum extent of conversion (98.93%) was predicted when the cardanol was condensed with formaldehyde (molar ratio 1:0.652) at 119.84 °C for a time period of 3 h with the catalyst (e.g., citric acid) concentration of 1.988% of total volume of cardanol and formaldehyde. The pH of the reaction mixture was maintained at 3.0. These predicted values for optimum process conditions were in good agreement with experimental data.     

Photosensitization of TiO2 colloids by Erythrosin B in acetonitrile

Photosensitization by Erythrosin B of a TiO₂ colloidal dispersion in acetonitrile has been studied by fast kinetic spectroscopy. The dye molecules adsorbed on the TiO₂ surface had a significantly shorter lifetime (2&#x0303; 250 ps) compared to those in homogeneous solution (≈ 1.6 ns) in acetonitrile. The photosensitization of TiO₂ occurred more efficiently from the singlet than from the triplet state of the dye.