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The molybdenum complexes of Schiff base ligands viz. [MoO2LH2O] where L1 = tris(hydroxymethyl)(salicylide-neamino)methane, L2 = tris(hydroxymethyl)(2,3-dihydroxybenzylideneamino)methane and L3 = tris(hydroxymethyl)(2,3,4-trihydroxybenzylideneamino)methane have been synthesized and characterized by spectroscopic and electrochemical techniques. The X-ray crystal structure of the complex [MoO2L1H2O] reveals a distorted octahedral geometry with one ligand and a water molecule coordinated to the MoO2 center. No previous complex of this type contains a coordinated water molecule. The complex undergoes an oxotransfer in the presence of Bu3P to form a -oxobridged molybdenum(V,V) dimer. This rules out Mo—S coordination as a prerequisite for oxotransfer in such molybdenum(VI) complexes. 相似文献
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Zahra Afrasiabi Rosana Almudhafar Di Xiao Ekkehard Sinn Amitava Choudhury Aamir Ahmad Alok Vyas Fazlul Sarkar Subhash Padhye 《Transition Metal Chemistry》2013,38(6):665-673
A planar, polycyclic and aromatic hydrocarbon ligand, namely 9,10-phenanthrenequinone semicarbazone, and its transition metal complexes have been synthesized and structurally characterized. The in vitro antiproliferative activity of these compounds against five human cancer cell lines revealed that they were effective against androgen receptor-positive/negative prostate cancer cells as well as COX-positive pancreatic BxPC-3 cancer cell line. The driving force behind such antiproliferative activity seems to be the up-regulated COX expression in these cells, which was amenable for targeting through metal complexation. These structural motifs can, therefore, serve as a starting point for developing novel cytotoxic agents against the growing number of prostate and pancreatic cancers. 相似文献
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The crystal structure of the potential antitumor metal compound, viz. chloro, mono(phenanthrenequinone thiosemicarbazonato) palladium(II) dimethyl formamide solvate, is reported. The central palladium(II) atom is in a square planar environment provided by the tridentate, monoanionic thiosemicarbazone ligand and the ancillary chloride ion. The compound exhibited remarkable activity against drug-sensitive and drug-resistant breast cancer cell lines and was relatively nontoxic toward the normal mammary epithelial cells. The drug-induced killing effect against breast cancer cell lines was predominantly mediated via apoptosis, a physiologic form of cell death. 相似文献
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Avinash Kumbhar Pramila Sonawane Subhash Padhye Douglas X. West Ray J. Butcher 《Journal of chemical crystallography》1991,27(9):533-539
The structures of two antitumor agents, 2-acetylpyridinethiosemicarbazone hemihydrate (1), C18H11N4O0.5S, colorless,M
r
203.3, monoclinic,P21
lc,a=16.713(3),b=9.460(2),c=12.642(2) ?, β=97.60(1)°,V=1981.2(6) ?3,Z=8,R=0.054,R
w
=0.085 and 2-acetylpyridinethiosemicarbazone hydrochloride (2), C18H12N4SCl, yellow,M
r
=230.7, monoclinic,P21
ln,a=7.676(2),b=7.889(1),c=17.452(4), ?, β=100.96(2)°,V=1037.5(4) ?3
Z=4,R=0.041,R
w
=0.076, have been determined. Both compounds exhibit an E configuration(S atomtrans to the N atom of the hydrazine group). Three hydrogen bonds link the two crystallographically independent molecules in a
pairwise fashion in the hemihydrate. An intramolecular N−H...Cl bond lends extra conformational stability to the hydrochloride
salt. 相似文献
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V. G. Puranik S. S. Tavale A. S. Kumbhar R. G. Yerande S. B. Padhye R. J. Butcher 《Journal of chemical crystallography》1992,22(6):725-731
The structure of the new tetranucleating ligand 2,3,-dihydroxy benzenemethanimine -(2-hydroxymethyl)phenyl has been determined by X-ray diffraction techniques. C14H13NO3 is monoclinic, space groupP21/a, with cell dimensionsa=10.382(2),b=19.147(1),c=12.799(1) Å,=113.08(1)°,V=2340.6(3) Å3,Z=8,M=243.04,D
o=1.36,D
x=1.38 mg/m3,F(000)=1024,T=293 K,R=0.041 for 2640 observed reflections. There are two molecules in the asymmetric unit and both have a similar geometry. The molecules are parallel to each other, the distance between them being 3.7 Å and the dihedral angle between mean planes 7.8°. There is a pseudocenter between molecule A and (1–x, 1–y, 1–z) of molecule B. The structure is stabilized by intramolecular O-HN and intermolecular O-HO as well as by C-HO hydrogen bonds.NCL Communication No. 5332. 相似文献
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Avinash S. Kumbhar Mahesh P. Mulay Subhash B. Padhye Sudam S. Tavale Vedavati G. Puranik 《Structural chemistry》2008,19(5):735-740
Crystal structure of {[Mn(salicylaldoximeH)(salicylaldoxime)]4} · 3CHCl3 1 formed by the interaction of MnCl2 · 4H2O and salicylaldoxime in a 1:1 ratio is described. The compound crystallizes in the orthorhombic space group Pbca (No 61) with the lattice parameters; a = 27.769 (3), b = 22.672 (2), c = 21.650 (2) Å, V = 13630 (2) Å3, Z = 8, R 1 = 0.0776, wR 2 = 0.2356, S = 1.164. The cluster with four Mn (III) centers formed by four terminal and four bridging salicylaldoxime ligands results in a central rotating wheel-like core with the Mn–Mn separation varying from 3.531 to 3.576 Å and with the diagonal distances being 4.156–4.165 Å. Four intramolecular H-bonds between a terminal oxime (NOH) group and the adjacent phenolate oxygen atom of another ligand stabilize the structure of the cluster. Spectral, magnetic, and cyclic voltammetry studies corroborate a stable Mn (III) tetramer. 相似文献
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Pramila Sonawane Avinash Kumbhar Subhash Padhye Ray J. Butcher 《Transition Metal Chemistry》1994,19(3):277-282
Summary Phenyl pyruvate thiosemicarbazone (H2PPVATSC) coordinates in its binegative thiolate form to cobalt(III) in the complex isolated from basic medium. An X-ray structure determination of the resulting meridional isomer was found to contain mutually cis sulphur, trans nitrogen, and trans oxygen donor atoms, respectively. The two five-membered rings formed by each ligand are puckered towards each other, resulting in a distortion from regular octahedral geometry about the cobalt atom. The complex was found to exhibit only a metal-based one electron reversible reduction at -0.97 V, while the parent ligand yields a c.v. profile consisting of two irreversible reduction peaks at -0.75 and -1.05V respectively, the latter corresponding to the reduction of the azomethine group. 相似文献