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1.
Martin Kellert Jan-Simon Jeshua Friedrichs Nadine Anke Ullrich Alexander Feinhals Jonas Tepper Peter Lnnecke Evamarie Hey-Hawkins 《Molecules (Basel, Switzerland)》2021,26(7)
The development of novel, tumor-selective and boron-rich compounds as potential agents for use in boron neutron capture therapy (BNCT) represents a very important field in cancer treatment by radiation therapy. Here, we report the design and synthesis of two promising compounds that combine meta-carborane, a water-soluble monosaccharide and a linking unit, namely glycine or ethylenediamine, for facile coupling with various tumor-selective biomolecules bearing a free amino or carboxylic acid group. In this work, coupling experiments with two selected biomolecules, a coumarin derivative and folic acid, were included. The task of every component in this approach was carefully chosen: the carborane moiety supplies ten boron atoms, which is a tenfold increase in boron content compared to the l-boronophenylalanine (l-BPA) presently used in BNCT; the sugar moiety compensates for the hydrophobic character of the carborane; the linking unit, depending on the chosen biomolecule, acts as the connection between the tumor-selective component and the boron-rich moiety; and the respective tumor-selective biomolecule provides the necessary selectivity. This approach makes it possible to develop a modular and feasible strategy for the synthesis of readily obtainable boron-rich agents with optimized properties for potential applications in BNCT. 相似文献
2.
Thermodynamic study of transthyretin association (wild‐type and senile forms) with heparan sulfate proteoglycan: pH effect and implication of the reactive histidine residue
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Ambre Geneste Claire André Nadine Magy‐Bertrand Lydie Lethier Gharbi Tijani Yves Claude Guillaume 《Biomedical chromatography : BMC》2015,29(4):514-522
The tetramer destabilization of transthyretin into monomers and its fibrillation are phenomena leading to amyloid deposition. Heparan sulfate proteoglycan (HSPG) has been found in all amyloid deposits. A chromatographic approach was developed to compare binding parameters between wild‐type transthyretin (wtTTR) and an amyloidogenic transthyretin (sTTR). Results showed a greater affinity of sTTR for HSPG at pH 7.4 compared with wtTTR owing to the monomeric form of sTTR. Analysis of the thermodynamic parameters showed that van der Waals interactions were involved at the complex interface for both transthyretin forms. For sTTR, results from the plot representing the number of protons exchanged vs pH showed that the binding mechanism was pH‐dependent with a critical value at a pH 6.5. This observation was due to the protonation of a histidine residue as an imidazolium cation, which was not accessible when TTR was in its tetrameric structure. At pH >6.5, dehydration at the binding interface and several contacts between nonpolar groups of sTTR and HSPG were also coupled to binding for an optimal hydrogen‐bond network. At pH <6.5, the protonation of the His residue from sTTR monomer when pH decreased broke the hydrogen‐bond network, leading to its destabilization and thus producing slight conformational changes in the sTTR monomer structure. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
3.
Let A be a symmetric matrix of size n×n with entries in some (commutative) field K. We study the possibility of decomposing A into two blocks by conjugation by an orthogonal matrix T∈Matn(K). We say that A is absolutely indecomposable if it is indecomposable over every extension of the base field. If K is formally real then every symmetric matrix A diagonalizes orthogonally over the real closure of K. Assume that K is a not formally real and of level s. We prove that in Matn(K) there exist symmetric, absolutely indecomposable matrices iff n is congruent to 0, 1 or −1 modulo 2s. 相似文献
4.
Jaime Keller 《International Journal of Theoretical Physics》1991,30(2):137-184
From the definition of spinors as the minimal left (right) modules of multivectors (that is, of vectors and their outer products), we can construct a unified mathematical approach for the study of matter and its interaction fields, which are either defined as fields in the geometrical spacetime or considered as generators of the physical spacetime. It is also shown how matter and interaction fields can be represented either by spinor fields or by multivector fields, both types of fields carrying the same information as the traditional corresponding spinors, vectors, or tensors. Geometry is more transparent in one representation (multivector form), and physics is more obvious in the spinor representation. Our theory provides a unified and totally self-consistent representation of quarks (barions), leptons, and all their known interactions. 相似文献
5.
Keller Teichmann Hans Pfeiffer W. Langenbeck A. Reid Heinrich Menzel Th. Höpner W. Mühlsteph M. Ulmann Geib R. E. Liesegang 《Colloid and polymer science》1939,87(1):100-104
Ohne Zusammenfassung 相似文献
6.
The effect of viscous dissipation on the development of the boundary layer flow from a cold vertical surface embedded in a Darcian porous medium is investigated. It is found that the flow evolves gradually from the classical Cheng–Minkowycz form to the recently discovered asymptotic dissipation profile which is a parallel flow. 相似文献
7.
8.
Each convex planar set K has a perimeter C, a minimum width E, an area A, and a diameter D. The set of points (E,C, A1/2, D) corresponding to
all such sets is shown to occupy a cone in the non-negative orthant of R4with its vertex at the origin. Its three-dimensional cross section S in the
plane D = 1 is investigated. S lies in a rectangular parallelepiped in R3. Results of Lebesgue, Kubota, Fukasawa, Sholander, and Hemmi are used to
determine some of the boundary surfaces of S, and new results are given for the other boundary surfaces. From knowledge of S, all inequalities among
E, C ,A, and D can be found. 相似文献
9.
B. Pümpin H. Keller W. Kündig I. M. Savić J. W. Schneider H. Simmler P. Zimmermann E. Kaldis S. Rusiecki C. Rossel 《Hyperfine Interactions》1991,63(1-4):25-31
A systematic μSR study of the local magnetic field distribution in a series of oxygen deficient YBa2Cu3O
x
samples with 6.5⩽x⩽7.0 is reported. Special attention was given to perform the experiments under the same conditions, so that the oxygen content
of the measured samples was the only parameter varied. The behavior of the depolarization rate σ as a function of the oxygen
contentx was found to have strong similarities with the behavior of the critical temperatureT
c
as a function ofx. In particular, two step-like increases of σ were observed abovex=6.7 and 6.9. The temperature dependence of the normalized depolarization rate σ(T)/σ(0) is well described by the two-fluid model forx⩾6.781(1) and clearly deviates from this behavior forx⩽6.704(1). Our results are compared to those obtained by other groups. 相似文献
10.
Based on the SU(n)-algebra the Markoff master equation in discrete product space is reformulated to explicitly deal with composite systems. The resulting local (single node) and nonlocal (multi-node) state parameters allow a systematic approach to non-classical features of the state, like variance and covariance tensors. For local optical driving forces, inter-node interactions, and local damping channels the solution of the master equation is unraveled into stochastic quantum trajectories. Sampling leads to a joint distribution function in terms of those state parameters. Its linear moments define the ensemble-density matrix. The average variance and covariance are in terms of non-linear moments, which should be distinguished from their entirely statistical counterpairs. Non-classicality of the network dynamics is shown to reflect itself in the luminescence-photonstatistics. 相似文献