Greener approach: Ionic liquid [Et3NH][HSO4]-catalyzed multicomponent synthesis of 4-arylidene-2-phenyl-5(4H)oxazolones under solvent-free condition

We have developed simple, greener, safer multicomponent synthesis series of 4-arylidene-2-phenyl-5(4H) oxazolones 4(a-r) catalyzed by Bronsted acid ionic liquid as triethylammonium hydrogen sulfate [Et₃NH][HSO₄] and catalytic amount of acetic anhydride and sodium acetate with excellent yields (90–99%). The protocol offers economical, environmentally benign, solvent-free conditions, and recycle–reuse of the catalyst and easily available starting as benzoyl chloride 1, amino acid 2 and a variety of aldehydes 3. The cyclization followed by condensation of benzoyl chloride, amino acid, and a variety of aldehydes catalyzed by ILs [Et₃NH][HSO₄] and catalytic amount of acetic anhydride and sodium acetate. The final products were confirmed by their characterization data such as FTIR, ¹H-NMR, ¹³C-NMR, Mass, high-resolution mass spectra and were compared with its reported method.     

[Bu3NH][HSO4] catalyzed: an eco-efficient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

Research on Chemical Intermediates - A Brønsted acidic ionic liquid [Bu3NH][HSO4] as an eco-efficient catalyst for the one-pot multicomponent synthesis of...     

DMP （1,1,1-Triacetoxy- 1,1-dihydro- 1,2-benziodoxol-3（1H）-one）： A novel catalyst for synthesis of 2-substituted benzimidazoles derivatives

Various 2-arylbenzimidazoles were synthesized from o-phenylenediamine and aldehydes via one-step process using DMP (Dess-Martin-periodinane) reagent as an oxidant.The method was proved to be simple,convenient and the products were isolated with good yields(80-90%).     

Synthesis and antimicrobial activity of 2-(4-(benzo[d]thiazol-5-ylsulfonyl)piperazine-1-yl)-N-substituted acetamide derivatives

A new series of 2-(4-(benzo[d]thiazol-5-ylsulfonyl)piperazin-1-yl)-N-substituted acetamide (5a-5k) compounds have been synthesized, and these compounds were characterized with spectral data like IR, NMR, and Mass spectroscopy. All compounds were evaluated in vitro for their efficacy as antimicrobial against Gram-positive and Gram-negative pathogenic bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa using ciprofloxacin as a standard and fungal strains like Candida albicans and Aspergillus fumigatus as compared with standard drug Clotrimazole, and Molecular docking study shows that all these compounds were having good to excellent correlation binding energy as compared with binding energy of standard drugs.     

Novel task-specific ionic liquid [Et2NH(CH2)2CO2H][AcO] as a robust catalyst for the efficient synthesis of some pyran-annulated scaffolds under solvent-free conditions

Research on Chemical Intermediates - A novel task-specific ionic liquid, 2-carboxy-N,N-diethylethanaminium acetate denoted as [Et2NH(CH2)2CO2H][AcO], is prepared in an easy process and fully...     

Effect of ionic strength on the stabilities of ciprofloxacin – Metal complexes

Proton–ligand dissociation constant of 1-cyclopropyl-1,4-dihydro-4-oxo-7-(1-piperazinyl) quinolone-3-carboxylic acid is ciprofloxacin and metal–ligand stability constants of its complexes with some metal ions have been determined potentiometrically in the presence of (0.01, 0.02 and 0.03 mol/dm³) NaClO₄. The order of the stability constants of the formed complexes increases in the sequence Cu²⁺, Fe³⁺, Ni²⁺ and Zn²⁺ and decreases with increase in the concentration of ionic strength.     

Sand: A natural and potential catalyst in renowned Friedel Craft's acylation of aromatic compounds

The aim of this work is to develop a cheap and green chemical process and this paper describes the catalytic commotion of locally collected sand in Friedel–Craft's Acylation of aromatic compounds like benzene, anisole, aniline, naphthalene and phenol etc. The sand consists of silica and alumina as analyzed by means of EDAX and acts as a green Lewis acid. The catalyst was also characterized by using BET, SEM, and XRD techniques.     

COD reduction of waste water streams of active pharmaceutical ingredient – Atenolol manufacturing unit by advanced oxidation-Fenton process

Active pharmaceutical intermediates (API) in waste waters have adverse effects on aquatic life and environment. The API have high COD value and low BOD₃ and hence difficult to treat biologically. In this study, advanced oxidation processes (AOPs) utilizing the H₂O₂/Fe⁺², Fenton reactions were investigated in lab-scale experiments for the degradation of Atenolol containing waste water streams. The experimental results showed that the Fenton process using H₂O₂/Fe⁺² was the most effective treatment process. With Fenton processes, COD reduction of wastewater can be achieved successfully. It is suggested that Fenton processes are viable techniques for the degradation of Atenolol from the waste water stream with relatively low toxic by-products in the effluent which can be easily biodegraded in the activated sludge process. Hence, the Fenton process with H₂O₂/Fe⁺² is considered a suitable pretreatment method to degrade the active pharmaceutical molecules and to improve the biodegradability of waste water.     

Use of diphenylamine reagent for high-performance thin-layer chromatographic detection of organochloro insecticide endosulfan in biological samples

JPC – Journal of Planar Chromatography – Modern TLC -     

New chromogenic reagent for high-performance thin-layer chromatographic detection of organophosphorus insecticide monocrotophos in biological materials

JPC – Journal of Planar Chromatography – Modern TLC -