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Satish R. Patil Ketan K. Nerurkar Ashok M. Kalamkar Vishwas Pukale Kiran V. Mangaonkar Satish G. Pingale 《Journal of mass spectrometry : JMS》2012,47(1):23-28
An analytical method based on liquid–liquid extraction has been developed and validated for analysis of agomelatine in human plasma. Fluoxetine was used as an internal standard for agomelatine. A Betasil C18 (4.0 × 100 mm, 5 µm) column provided chromatographic separation of analytes followed by detection with mass spectrometry. The method involves simple isocratic chromatographic conditions and mass spectrometric detection in the positive ionization mode using an API‐4000 system. The proposed method has been validated with linear range of 0.050–8.000 ng/ml for agomelatine. The intra‐run and inter‐run precision values are within 12.12% and 9.01%, respectively, for agomelatine at the lower limit of quantification level. The overall recovery for agomelatine and fluoxetine was 67.10% and 72.96%, respectively. This validated method was used successfully for analysis of plasma samples from a pharmacokinetic study. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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Banerjee Ananya Sane Ramesh T. Mangaonkar Kiran Shailajan Sunita Deshpande Abhijeet Gundi Gunesh 《平面色谱法杂志一现代薄层色谱法》2006,19(1):68-72
JPC – Journal of Planar Chromatography – Modern TLC - A sensitive, simple, and accurate high-performance thin-layer chro-matographic method has been established for determination of... 相似文献
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Satish Gangaram Pingale Ketan K. Nerurkar Ajit M. Padgaonkar Uttam D. Pawar Kiran V. Mangaonkar 《Chromatographia》2009,70(5-6):947-951
A sensitive and selective method for the determination of atovaquone in human plasma was developed and validated. The procedure employed the use of an internal standard (chlorothalidone) and a solvent extraction step. Detection was by electrospray ionization tandem mass spectrometry with multiple reaction monitoring. The method showed a linear range from 50 to 2,000 ng mL?1. The extraction recovery was determined to be 84.91 ± 6.42% (SD), the intra- and inter-day assay accuracy (relative error) was within 7.57% and precision (RSD) was below 6.06%. The method was successfully employed to analyze plasma samples and evaluate the pharmacokinetics of atovaquone in human volunteers. 相似文献
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Satish G. Pingale Ketan K. Nerurkar Ajit M. Padgaonkar Uttam D. Pawar Kiran V. Mangaonkar 《Chromatographia》2009,70(7-8):1095-1102
An alternative rapid and sensitive liquid chromatography–tandem mass spectrometry method has been developed and validated for simultaneous analysis of proguanil (PRO) and cycloguanil (CYC) in human plasma. The analytes were extracted from human plasma by solid phase extraction. Riluzole (RIL) was used as an internal standard for proguanil and cycloguanil. A HyPURITY Advance C18 column provided chromatographic separation of analytes followed by detection with mass spectrometry. The method involves simple isocratic chromatography conditions and mass spectrometric detection in the positive ionization mode using an API-4000 system. The proposed method has been validated with linear range of 1.5–150.0 ng mL?1 for PRO and 0.5–50.0 ng mL?1 for CYC. The inter-run and intra-run precision values are within 2.54, 9.19% for PRO and 1.99, 10.69% for CYC at LOQ levels. The overall recoveries for PRO and CYC were 102.52 and 106.72%, respectively. Total elution time was as low as 2.50 min. This validated method was used successfully for analysis of plasma samples from a bioequivalence study. 相似文献
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Patil SR Nerurkar KK Kalamkar AM Pukale V Mangaonkar KV Pingale SG 《Journal of mass spectrometry : JMS》2012,47(1):23-28
An analytical method based on liquid-liquid extraction has been developed and validated for analysis of agomelatine in human plasma. Fluoxetine was used as an internal standard for agomelatine. A Betasil C18 (4.0?×?100?mm, 5?μm) column provided chromatographic separation of analytes followed by detection with mass spectrometry. The method involves simple isocratic chromatographic conditions and mass spectrometric detection in the positive ionization mode using an API-4000 system. The proposed method has been validated with linear range of 0.050-8.000?ng/ml for agomelatine. The intra-run and inter-run precision values are within 12.12% and 9.01%, respectively, for agomelatine at the lower limit of quantification level. The overall recovery for agomelatine and fluoxetine was 67.10% and 72.96%, respectively. This validated method was used successfully for analysis of plasma samples from a pharmacokinetic study. 相似文献
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Shetty Prabha G. Mangaonkar Kiran V. Sane Ramesh T. Jaripatke Kamlakar K. Singh Shweta 《平面色谱法杂志一现代薄层色谱法》2007,20(2):117-120
JPC – Journal of Planar Chromatography – Modern TLC - A simple and rapid high-performance thin-layer chromatographic method has been established and validated for determination of... 相似文献
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An elegant approach for the rapid synthesis of β-cyanoepoxides 3 by the epoxidation of β-cyanostyrenes 1 with PIDA 2a is described. The epoxidation of β-cyanostyrenes 1 was performed with 1.2 equiv. of PIDA 2a in MeCN-H2O (1:1) at room temperature in ultrasonic bath. The epoxidation reactions were completed in short reaction time and β-cyanoepoxides 3 were isolated in 69–94% yields. 相似文献
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