Convenient and Scalable Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives and Their Anticancer Activities

An efficient and mild InBr₃-catalyzed approach to synthesize 2,3-dihydroquinazolin-4(1H)-one derivatives (3a–3aa) has been developed. Notably, all the products were isolated by recrystallization and the reaction is accessible on a gram scale. Moreover, the reactions only require 10–60 min. All the synthesized compounds were evaluated for their in vitro anticancer activity against four human cancer cell lines.     

PEG-400 as an efficient and recyclable reaction medium for the synthesis of 2-aryl-2-methyl-4,5-diphenyl-2,3- dihydro-2H-imidazoles

A productive natural method has been produced for the synthesis of 2-aryl-2-methyl-4,5-diphenyl-2,3-dihydro-2H-imidazoles in great yields under catalyst free-conditions utilizing polyethylene glycol (PEG-400) as a green reaction medium. The highlights of this new method are shorter reaction times, good yields, room temperature, and use of nontoxic, inexpensive, and recyclable PEG-400.