Polyketide anthraquinone,diphenyl ether,and xanthone derivatives from the soil fungus Penicillium sp. PSU-RSPG99

Three new polyketides including one new diphenyl ether, penicillither (1), one new anthraquinone, penicilliquinone (2), and one new xanthone, penicillixanthone (3), together with twelve known compounds were isolated from the soil fungus Penicillium sp. PSU-RSPG99. Their structures were identified by spectroscopic evidence. In addition, the position of a chlorine atom in 1 was confirmed by the plausible biosynthetic pathway from the isolated chlorobenzophenone. Known GKK1032B displayed mild antimycobacterial and moderate cytotoxic (against human oral carcinoma, KB, human breast cancer, MCF-7, and noncancerous Vero cell lines) activities.     

Benzopyranone,benzophenone, and xanthone derivatives from the soil fungus Penicillium citrinum PSU-RSPG95

Two new benzopyranones, named coniochaetones E (1) and F (2), one new xanthone, penicillone C (3), and one new benzophenone, penicillanone (4), are isolated from the soil fungus Penicillium citrinum PSU-RSPG95, together with ten known compounds. Their structures are identified on the basis of spectroscopic data. The isolated compounds are evaluated for their cytotoxic activity.     

Indole-benzodiazepine-2,5-dione derivatives from a soil fungus Aspergillus sp. PSU-RSPG185

Six new indole-benzodiazepine-2,5-dione derivatives, asperdiazapinones A–F (1–6), together with three known prenylated indole alkaloids were isolated from the mycelial extract of the soil fungus Aspergillus sp. PSU-RSPG185. Their structures were established by spectroscopic evidence. For compounds 2 and 5, the structures were confirmed by single-crystal X-ray diffraction crystallography. Asperdiazapine B (2) displayed weak antimalarial and noncytotoxic activities.