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1.
Low-flow chromatography has a rich history of innovation but has yet to reach widespread implementation in bioanalytical applications. Improvements in pump technology, microfluidic connections, and nano-electrospray sources for MS have laid the groundwork for broader application, and innovation in this space has accelerated in recent years. This article reviews the instrumentation used for nano-flow LC, the types of columns employed, and strategies for multidimensionality of separations, which are key to the future state of the technique to the high-throughput needs of modern bioanalysis. An update of the current applications where nano-LC is widely used, such as proteomics and metabolomics, is discussed. But the trend toward biopharmaceutical development of increasingly complex, targeted, and potent therapeutics for the safe treatment of disease drives the need for ultimate selectivity and sensitivity of our analytical platforms for targeted quantitation in a regulated space. The selectivity needs are best addressed by mass spectrometric detection, especially at high resolutions, and exquisite sensitivity is provided by nano-electrospray ionization as the technology continues to evolve into an accessible, robust, and easy-to-use platform.  相似文献   
2.
We initiate a program to study certain recent problems in non-compact coset CFT by the BRST approach. We derive a reduction formula for the BRST cohomology by making use of a twisting by highest weight modules. As illustrations, we apply the formula to the bosonic string model and a rank one non-compact coset model [DPL]. Our formula provides a completely new approach to non-compact coset construction.Partially supported by NSF Grant DMS-8703581  相似文献   
3.
用模拟万用表测电容   总被引:1,自引:0,他引:1  
周炼刚 《物理实验》2002,22(3):36-37
介绍了用模拟万用表和秒表测量电容的简单方法,对测量结果的误差原因进行了分析,给出了提高测量精度的几点措施。  相似文献   
4.
Dirichlet boundary value problems for perturbed second-order differential equations on a half line are investigated in this paper. The methods mainly depend on the calculus of variations to the classical functionals. Sufficient conditions are obtained for the existence of the solutions.  相似文献   
5.
An equation to express ion exchange selectivity coefficient was derived and used for calculating that of PPY film with the results obtained by cyclic voltammetric measurement. PPY film was synthesized by electrochemical method in aqueous solution using K4Fe(CN)6 as supporting electrolyte, and the anions were doped into the film. Ion exchange behaviour of doped Fe (CN)63-/4- in the PPY film with Cl?, NO3? or F? ions in solution has been studied, and the corresponding ion exchange selectivity coefficients were determined.  相似文献   
6.
BEPCⅡ直线加速器的重大改造旨在获得高流强、小发射度和小能散的正负电子束, 以满足对撞机亮度提高两个两级的要求. 这对直线加速器各系统和束流物理是一个挑战. 文章介绍了直接决定束流性能的新电子源、新正电子源、新微波功率源、相位控制系统和束流测量系统等的改造情况; 叙述了束流物理研究; 介绍了束流调试进展情况和进一步改进计划.  相似文献   
7.
We study the superextension of the semi-infinite cohomology theory of the Virasoro Algebra. In particular, we examine the BRST complex with coefficients in the Fock Space of the RNS superstring. We prove a theorem of vanishing cohomology, and establish the unitary equivalence between a positive definite transversal space, a physical subspace and the zeroth cohomology group. The cohomology of a subcomplex is identified as the covariant equivalent of the well-known GSO subspace. An exceptional case to the vanishing theorem is discussed.Supported by NSF Grant DMS-8703581  相似文献   
8.
李雄杰  葛鲁波  孔凡才 《物理实验》2006,26(3):19-21,25
介绍了基于单片机控制技术的强电实验线路故障自动诊断系统的结构及功能,阐述了系统硬件设计、软件设计的基本原理.  相似文献   
9.
李慧陵  赵英  李廉 《中国科学A辑》1994,37(6):568-578
讨论了多项式理想准素分解的算法,对于理想坐标变换中关键的“一般位置”的计算,给出了一个确定算法,并建立了特别规范Groebner基的概念,利用这一概念及文中提供的相应算法,可以方便地计算理想的维数,进而使用降维的方法来得到高维理想的准素分解。  相似文献   
10.
In [33], we studied the constraint problem for two-dimensional quantum gravity in the conformal gauge. In this gauge, we proposed an ansatz for the gravitational sector. Using this ansatz, we established a striking connection between the matrix models and continuum 2D gravity. We also announced several results on semi-infinite homology of the Virasoro algebra with coefficients in a suitable class of positive energy modules. In this article, we will provide details of the proof of the announced results.Supported in part by the Alfred P. Sloan FoundationSupported by NSF Grant DMS-8703581  相似文献   
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