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Pehlivanovic Beco Avdic Senada Gazdic Izet Osmanovic Alma 《Journal of Radioanalytical and Nuclear Chemistry》2017,311(3):1909-1915
Journal of Radioanalytical and Nuclear Chemistry - This work presents measurements of activity concentrations and estimation of population exposure from the naturally occurring radionuclides 238U,... 相似文献
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Burgess JP Wintermute JS Thomas BF Kapetanovic IM 《Magnetic resonance in chemistry : MRC》2006,44(11):1051-1053
The complete assignments of all 1H and 13C chemical shifts were made for the fluorinated dehydroepiandrosterone (DHEA) analog fluasterone, 2, and two potential in vivo metabolites 3 and 4. The assignments were made using a combination of one- and two-dimensional NMR techniques (1H, 13C, gDQCOSY, gHSQC, gHMBC). Once the proton chemical shifts were assigned, the stereochemistry of the two hydroxylated analogs was determined using 2D ROESY experiments. 相似文献
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Benoit Louage Dr. Lutz Nuhn Dr. Martijn D. P. Risseeuw Nane Vanparijs Ruben De Coen Izet Karalic Prof. Dr. Serge Van Calenbergh Prof. Dr. Bruno G. De Geest 《Angewandte Chemie (International ed. in English)》2016,55(39):11791-11796
We report on the design of a polymeric prodrug of the anticancer agent paclitaxel (PTX) by a grafting‐from‐drug approach. A chain transfer agent for reversible addition fragmentation chain transfer (RAFT) polymerization was efficiently and regioselectively linked to the C2′ position of paclitaxel, which is crucial for its bioactivity. Subsequent RAFT polymerization of a hydrophilic monomer yielded well‐defined paclitaxel–polymer conjugates with high drug loading, water solubility, and stability. The versatility of this approach was further demonstrated by ω‐end post‐functionalization with a fluorescent tracer. In vitro experiments showed that these conjugates are readily taken up into endosomes where native PTX is efficiently cleaved off and then reaches its subcellular target. This was confirmed by the cytotoxicity profile of the conjugate, which matches those of commercial PTX formulations based on mere physical encapsulation. 相似文献
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