Finite-Time Stabilization of Differential Systems with Incommensurable Delays

Differential Equations - For a spectrally controllable linear autonomous system with incommensurable delays, we construct a dynamic state feedback in the form of a differential-difference...     

Multiparticle Effects in the Spectrum of Collective Excitations of Strongly Interacting Two-Dimensional Electron Systems (Brief Review)

JETP Letters - Extraordinary multiparticle effects in quantizing magnetic fields that are manifested in strongly interacting two-dimensional electron systems in MgZnO/ZnO heterostructures have been...     

Mesomorphism of Dichotomous Compounds; X-Ray Diffraction Analysis of 4-Chlorophenyl Hexadecyl Ether

Crystallography Reports - The crystal and molecular structures of Cl–C6H4–O–C16H33 (I) have been studied, and its differential scanning calorimetry (DSC) study is performed....     

Comparative Study of LiInSe2 Single Crystals for Thermal-Neutron Detection

Crystallography Reports - Two LiInSe2 single crystals, grown under different conditions, have been studied. Characteristics of these crystals for neutron detection have been compared using...     

Some Problems of Nonlinear Dynamics of Turbulent Thermals

Radiophysics and Quantum Electronics - A well-known simplified model of turbulent convection from local sources of buoyancy and/or momentum acting for a short time has been developed and...     

Composition and Antifungal Activity of Lipids from Seeds of Atriplex tatarica

Chemistry of Natural Compounds -     

Subdominant H60 antigen-specific CD8 T-cell response precedes dominant H4 antigen-specific response during the initial phase of allogenic skin graft rejection

In allogeneic transplantation, including the B6 anti-BALB.B settings, H60 and H4 are two representative dominant minor histocompatibility antigens that induce strong CD8 T-cell responses. With different distribution patterns, H60 expression is restricted to hematopoietic cells, whereas H4 is ubiquitously expressed. H60-specific CD8 T-cell response has been known to be dominant in most cases of B6 anti-BALB.B allo-responses, except in the case of skin transplantation. To understand the mechanism underlying the subdominance of H60 during allogeneic skin transplantation, we investigated the dynamics of the H60-specific CD8 T cells in B6 mice transplanted with allogeneic BALB.B tail skin. Unexpectedly, longitudinal bioluminescence imaging and flow cytometric analyses revealed that H60-specific CD8 T cells were not always subdominant to H4-specific cells but instead showed a brief dominance before the H4 response became predominant. H60-specific CD8 T cells could expand in the draining lymph node and migrate to the BALB.B allografts, indicating their active participation in the anti-BALB.B allo-response. Enhancing the frequencies of H60-reactive CD8 T cells prior to skin transplantation reversed the immune hierarchy between H60 and H4. Additionally, H60 became predominant when antigen presentation was limited to the direct pathway. However, when antigen presentation was restricted to the indirect pathway, the expansion of H60-specific CD8 T cells was limited, whereas H4-specific CD8 T cells expanded significantly, suggesting that the temporary immunodominance and eventual subdominance of H60 could be due to their reliance on the direct antigen presentation pathway. These results enhance our understanding of the immunodominance phenomenon following allogeneic tissue transplantation.