Ligands of the Gi protein-coupled adenosine A3 receptor (A3R) are receiving increasing interest as attractive therapeutic tools for the treatment of a number of pathological conditions of the central and peripheral nervous systems (CNS and PNS, respectively). Their safe pharmacological profiles emerging from clinical trials on different pathologies (e.g., rheumatoid arthritis, psoriasis and fatty liver diseases) confer a realistic translational potential to these compounds, thus encouraging the investigation of highly selective agonists and antagonists of A3R. The present review summarizes information on the effect of latest-generation A3R ligands, not yet available in commerce, obtained by using different in vitro and in vivo models of various PNS- or CNS-related disorders. This review places particular focus on brain ischemia insults and colitis, where the prototypical A3R agonist, Cl-IB-MECA, and antagonist, MRS1523, have been used in research studies as reference compounds to explore the effects of latest-generation ligands on this receptor. The advantages and weaknesses of these compounds in terms of therapeutic potential are discussed. 相似文献
The environmental impacts associated with the exploitation and transformation of fossil resources aggravate the planet's situation in terms of climate change. Due to this, this paper studies an alternative use of mineral coal as a precursor to obtaining new materials with different properties to the starting coals. The thermal degradation of two Colombian semi-anthracites is analyzed through the thermogravimetry (TG) technique coupled to a Fourier transform infrared spectroscopy (FTIR) equipment from room temperature (25 °C) to 900 °C, at a heating rate of 10 K min?1 in an inert atmosphere. The catalytic effect of the addition of silicon to these samples before being subjected to a carbonization process is evaluated during this process. The results indicated that the primary reaction occurs in the temperature range between 400 and 680 °C, where the highest mass loss rate was observed. At the end of the heating process, the TG profile of the samples with silicon addition showed losses between 14.33 and 18.82% in mass, these values being slightly higher compared to the starting and demineralized samples. The release of water, light gases such as CO2, CH4, and species such as toluene, phenol and formic acid was identified in most of the samples. The presence of silica seems to favor the release of all these species, being more evident in one of the semi-anthracites studied. According to the results obtained, it is proved that the presence of silicon in samples subjected to carbonization processes has a catalytic effect that improves some characteristics of the new materials obtained, thus contributing to the use of carbon to get new materials.
We perform a detailed analysis of the properties of stationary observers located on the equatorial plane of the ergosphere in a Kerr spacetime, including light-surfaces. This study highlights crucial differences between black hole and the super-spinner sources. In the case of Kerr naked singularities, the results allow us to distinguish between “weak” and “strong ” singularities, corresponding to spin values close to or distant from the limiting case of extreme black holes, respectively. We derive important limiting angular frequencies for naked singularities. We especially study very weak singularities as resulting from the spin variation of black holes. We also explore the main properties of zero angular momentum observers for different classes of black hole and naked singularity spacetimes. 相似文献
In the five-dimensional Kaluza–Klein (KK) theory there is a well known class of static and electromagnetic-free KK-equations
characterized by a naked singularity behavior, namely the Generalized Schwarzschild solution (GSS). We present here a set
of interior solutions of five-dimensional KK-equations. These equations have been numerically integrated to match the GSS
in the vacuum. The solutions are candidates to describe the possible interior perfect fluid source of the exterior GSS metric
and thus they can be models for stars for static, neutral astrophysical objects in the ordinary (four-dimensional) spacetime. 相似文献