手性氨基酚配体及其衍生物在不对称催化中的应用

综述了手性氨基酚配体及其衍生物的研究进展, 着重介绍其在不对称催化烷基化、烯基化、Michael加成、aldol反应及环丙化等反应中的应用.     

光学读出微梁阵列红外成像及性能分析

在构建的光学读出微梁阵列(焦平面阵列FPA)非制冷红外成像系统中，实现了无硅基底FPA置于空气中对人体的热成像. 通过FPA在不同真空度环境条件下的成像结果进行比较，分析了热导和系统噪声值随气压变化的关系，以及对系统成像性能的影响，并对气体分子热运动自由程大于空气传热层特征尺度时的气体热传导模型进行了修正分析和实验验证. 实验结果表明：FPA置于空气中时，气体分子撞击微梁引起的微梁反光板无序振动产生的光学读出噪声成为系统噪声的主要来源. 当真空度小于1Pa时，总热导和光学读出噪声值的变化都趋于平缓；当真空度小于10^-2Pa时，空气热导的影响可忽略，总热导降低到微梁感热像素的辐射极限，光学读出噪声也降低到一极小值. 实验结果与理论分析相符合. 关键词： 非制冷红外成像 光学读出 双材料微梁阵列 热导     

A practical and step-economic route to Favipiravir

A practical and step-economic route to Favipiravir, an antiviral drug, was developed. Favipiravir was synthesized in only six steps from 3-aminopyrazine-2-carboxylic acid with an overall yield of about 22.3%. Key intermediates 3 and 6 were obtained in excellent purity via recrystallization from optimized solvents, which was beneficial to large-scale production. In the key synthetic reaction, 3,6-dichloropyrazine-2-carbonitrile (6) was reacted sequentially, in one pot, with KF and 30% H₂O₂ to give (after crystallization from 95% EtOH) favipiravir as colorless crystals, with a 60% yield for this final step of the synthesis.     

Fmoc synthesis of peptide thioesters without post-chain-assembly manipulation

An operationally simple method for the synthesis of peptide thioesters is developed using standard Fmoc solid-phase peptide synthesis procedures. The method relies on the use of a premade enamide-containing amino acid which, in the final TFA cleavage step, renders the desired thioester functionality through an irreversible intramolecular N-to-S acyl transfer.     

Optimized Optomechanical Micro-Cantilever Array for Uncooled Infrared Imaging

We present a new substrate-free bimaterial cantilever array made of SiN_x and Au for an uncooled micro-optomechanical infrared imaging device. Each cantilever element has an optimized deformation magnification structure. A160×160 array with a 120μm×120μm pitch is fabricated and an optical readout is used to collectively measure deflections of all microcantilevers in the array. Thermal images of room-temperature objects with higher spatial resolution have been obtained and the noise-equivalent temperature difference of the fabricated focal plane arrays is given statistically and is measured to be about 270mK.     

像素偏振片阵列制备及其在偏振图像增强中的应用

像素偏振片阵列在实时测量光的斯托克斯参量方面具有重要的应用.本文设计和制作了基于金属铝纳米光栅的像素偏振片阵列,制作工艺基于电子束曝光技术.偏振片阵列单元尺寸为7.4μm,每相邻2×2单元的透偏振方向分别为0,7π/4,π/2和3π/4.光栅周期为140 nm,占空比为0.5,深度100 nm,光栅面型为矩形.像素偏振片阵列的扫描电子显微镜照片显示,制备的偏振片阵列的金属纳米光栅栅线无断线、无交叉、无杂物污染,光栅栅线结构平直,厚度均匀,满足理想矩形面型.采用偏振光作为照明光的光学显微镜拍摄图片显示,像素偏振片阵列整体形状规则,具有很好的偏振特性,最大偏振透射率可达到79.3%,消光比可达到454.将像素偏振片阵列与CCD(charge coupled device)集成在一起,采集单帧图像即可计算图像的斯托克斯参量,从而得到拍摄物体线偏振度图像和线偏振角图像,实现了偏振增强,可应用于目标反隐和识别.     

Polycrystalline Synthesis and Single Crystal Growth of AgGaS2

A modified two temperature vapor transport procedure has been used to synthesize AgGaS₂ polycrystalline materials at 1060 °C from high-purity Ag, Ga, S elements. The results showed that the polycrystalline materials are pure single phase AgGaS₂ by X-ray powder diffraction analysis. The polycrystalline ingot includes a few interior voids and has a high mass density. The AgGaS₂ ingot with 12 mm in diameter and 20 mm in length has been grown by the modified Bridgman technique in two-zone vertical furnace. As-grown AgGaS₂ ingot was characterized by the X-ray diffraction technique, obtained the rocking curve of the crystal (011) face, it is shown that the ingot is AgGaS₂ single crystal. The infrared transparent of the crystal at 2 ∼ 10μm is 49% (and absorption coefficient is 0.74 cm^—1).     

含三芳胺基的吡啶甲酸衍生物及其环金属铱配合物的合成与性能

通过Ullmann反应和Negishi偶联反应, 合成了一种含三芳胺功能基的吡啶-2-甲酸衍生物; 并以此为辅助配体、1-苯基异喹啉为环金属配体, 设计合成了一种新型环金属铱配合物. 该配合物的二氯甲烷溶液, 在391～461 nm范围呈现了强烈的金属-配体电荷转移(MLCT)电子跃迁吸收带; 其最大发光波长为609 nm. 与传统的二(1-苯基异喹啉)(吡啶-2-甲酸)合铱配合物相比, 设计的环金属铱配合物具有增强的MLCT电子跃迁吸收和低的氧化电位, 是一种有发展潜力的红色磷光材料.     

双材料微梁阵列室温物体红外成像

针对近年出现的新概念光学读出双材料微梁阵列红外成像技术，提出了具有热变形放大效果的无硅基底回折腿间隔镀金的微梁单元结构,并建立了其热机械模型，在模型分析基础上，成功的设计制作了100×100像素的焦平面阵列(focal plane array,FPA).在构建的红外成像系统中，实现了对室温物体——人体的热成像，噪声等效温度差约为200mK.实验结果与热机械模型的分析一致. 关键词： 非制冷红外成像 光学读出 双材料微梁阵列     

乙二醛缩双(邻氨基苯酚)合锰(II)配合物的合成及其催化行为研究

合成了乙二醛缩双(邻氨基苯酚)合锰(II)配合物, 讨论了其在DMF中的载氧行为、氧合动力学; 设计正交试验考察了以分子氧为氧源, 该配合物催化氧化醋酸去氢表雄酮生成7-酮基醋酸去氢表雄酮的性能, 最高收率达78.4%.