排序方式: 共有32条查询结果,搜索用时 15 毫秒
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An automated flow-injection system with a computer-controlled sample changer, injection device and digital photometer is described, for use with an Apple II. The software is understandable, flexible and easily adaptable to different computers provided with the programming language FORTH. 相似文献
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Klaus Dohmen 《Results in Mathematics》1998,33(1-2):87-88
In this paper, we present a simple inductive proof of some recently published bounds to the chromatic polynomial of a graph. 相似文献
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A Single Methylene Group in Oligoalkylamine‐Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery
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Anita Jarzębińska Dr. Tamara Pasewald Jana Lambrecht Olga Mykhaylyk Linda Kümmerling Dr. Philipp Beck Dr. Günther Hasenpusch Priv.‐Doz. Dr. Carsten Rudolph Prof. Dr. Christian Plank Dr. Christian Dohmen 《Angewandte Chemie (International ed. in English)》2016,55(33):9591-9595
The development of chemically modified mRNA holds great promise as a new class of biologic therapeutics. However, the intracellular delivery and endosomal escape of mRNA encapsulated in nanoparticles has not been systematically investigated. Here, we synthesized a diverse set of cationic polymers and lipids from a series of oligoalkylamines and subsequently characterized their mRNA delivery capability. Notably, a structure with an alternating alkyl chain length between amines showed the highest transfection efficiency, which was linked to a high buffering capacity in a narrow range of pH 6.2 to 6.5. Variation in only one methylene group resulted in enhanced mRNA delivery to both the murine liver as well as porcine lungs after systemic or aerosol administration, respectively. These findings reveal a novel fundamental structure–activity relationship for the delivery of mRNA that is independent of the class of mRNA carrier and define a promising new path of exploration in the field of mRNA therapeutics. 相似文献
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Klaus Dohmen 《Journal of Graph Theory》1993,17(1):75-80
In this paper we give lower bounds and upper bounds for chromatic polynomials of simple undirected graphs on n vertices having m edges and girth exceeding g © 1993 John Wiley & Sons, Inc. 相似文献
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Dr. Dominik Albat Dr. Slim Chiha Dr. Stephan Dohmen Pascal M. Engelhardt Dr. Hanna Sebode Dr. Arne Soicke Dr. Matthias Barone Dr. Matthias Müller Dr. Ronald Kühne Prof. Dr. Hans-Günther Schmalz 《European journal of organic chemistry》2023,26(39):e202300771
In the search for efficient inhibitors for the enabled/vasodilator-stimulated phosphoprotein homology 1 (EVH1) domain to reduce cell motility in metastatic cancer, we previously developed a toolkit of proline-derived modules (ProMs), which mimic the PPII helix found in the natural −FPPPP− binding motif of EVH1. In this work, we describe the modular assembly of these ProM-based pentapeptidic EVH1 ligands through liquid phase peptide synthesis. We initially used pentafluorophenyl (Pfp) active esters for amide bond formation and built up the growing peptide chain from the C- to the N-terminus. Switching to HATU/DIPEA coupling conditions and changing the directionality of the synthesis from the N- to the C-terminus afforded the target ligands with improved overall yields and purity. Employing a Fmoc-protected (instead of the N-acetylated) phenylalanine derivative as N-terminal building block significantly reduced epimerization. In contrast to the originally used solid phase peptide synthesis (SPPS), the developed solution phase method allowed for a facile alteration of the C-terminal ProM unit and the production of various pentapeptidic ligands in an efficient fashion even on a multigram scale. 相似文献