Identification of pyrrolo-pyridine derivatives as novel class of antibacterials

Molecular Diversity - A series of 5-oxo-4H-pyrrolo[3,2-b]pyridine derivatives was identified as novel class of highly potent antibacterial agents during an extensive large-scale high-throughput...     

Electrical and magnetoresistive properties of nanogranular CoFeB-CaF2

The electrical properties and magnetoresistance of (Co₄₁Fe₃₉B₂₀) _x (CaF₂)_{100 ? x} composite are investigated. The principal mechanisms of electric charge transfer at low temperatures are determined. The effective density of localized states at the Fermi level and the average number of localized states between adjacent granules at various concentrations of the metal phase are estimated.     

Investigation of internal stresses in glass-reinforced plastics

The strength properties of and internal stresses in epoxy and epoxyphenol resins and GRPs based on them are investigated using an optical method of determining internal stresses. The GRPs had tape and fabric reinforcement. Compared with the internal stresses in unplasticized specimens, the stresses in pure resin films and in GRPs based on plasticized resins are found to be smaller. It is shown that the distribution of internal stresses in GRPs is anisotropic. The highest internal stresses are observed in tape-reinforced GRPs in a direction normal to the fibers. Glass reinforcement in two directions at right angles reduces the internal stresses in GRPs as compared with pure resin films. In both reinforced and unreinforced films, the internal stresses depend on the curing conditions.Mekhanika polimerov, Vol. 1, No. 1, pp. 82–88, 1965     

Deconvolution filters to enhance resolution of dense time-of-flight survey spectra in the time-lag optimization range

By applying time-domain filters to time-of-flight (TOF) mass spectrometry signals, we have simultaneously smoothed and narrowed spectra resulting in improved resolution and increased signal-to-noise ratios. This filtering procedure has an advantage over detailed curve fitting of spectra in the case of large dense spectra, when neither the location nor the number of mass peaks is known a priori. This time series method is directly applicable in the time lag optimization range, where point density per peak is constant. We present a systematic methodology to optimize the filters according to any desired figure of merit, illustrating the procedure by optimizing the signal-to-noise per unit bandwidth of matrix-assisted laser desorption/ionization (MALDI) data. We also introduce a nonlinear filter that reduces the spurious structure that often accompanies deconvolution filters. The net result of the application of these filters is that we can identify new structures in dense MALDI-TOF data, clearly showing small adducts to heavy biomolecules.     

Methods for modified nucleotide identification in ribosomal RNA

Modified nucleotides are ubiquitous in all functional RNA, such as ribosomal RNA. The identification of modified nucleotides is essential for understanding the functional role of RNA in living cells. This review is devoted to methods used to identify modified nucleotides in ribosomal RNA.     

Colloid and Nanosized Catalysts in Organic Synthesis: XIX.<Superscript>1</Superscript> Influence of the Support Nature on Hydrogenation Catalysis of Cyclic Olefins by Nickel Nanoparticles

Gas-phase hydrogenation of cycloalkenes in the presence of nickel nanoparticles supported on Ceokar-2, BAU-A activated carbon, alumina, and NaX zeolite proceeds at 140–240°C and atmospheric pressure of hydrogen. The conversion and selectivity depend on the type of support and on the hydrogen excess.     

Synthesis,molecular, and crystalline structure of 3-benzoyl-1,2-di(ethylsulfonyl)indolizine

Reaction of pyridiniumbenzoyl methylide with (E)-1,2-di(ethylsulfonyl)-1,2-dichloroethene (which has four nucleophilic groups) occurs via a 1,3-dipolar stereo- and regio directed cycloaddition to give 3-benzoyl-1,2-di(ethylsulfonyl)indolizine the structure of which was established using x-ray crystallography. The rotation of the phenyl substituted by 72.6° relative to the indolizine ring plane and the geometry of the ethylsulfonyl groups can be explained by steric hindrance due to shortened intramolecular non-valence contacts.Deceased.A. N. Nesmeyanov Institute of Organoelemental Compounds, Russian Academy of Sciences, Moscow 117813. N. D. Zelinski Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 117913. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 950–954, July, 1996. Original article submitted May 5, 1996.     

Automated assignment of ionization states in broad‐mass matrix‐assisted laser desorption/ionization spectra of protein mixtures

A computational technique is presented for the automated assignment of the multiple charge and multimer states (ionization states) in the time‐of‐flight (TOF) domain for matrix‐assisted laser desorption/ionization (MALDI) spectra. Examples of the application of this technique include an improved, automatic calibration over the 2 to 70 kDa mass range and a reduced data redundancy after reconstruction of the molecular spectrum of only singly charged monomers. This method builds on our previously reported enhancement of broad‐mass signal detection, and includes two steps: (1) an automated correction of the instrumental acquisition initial time delay, and (2) a recursive TOF detection of multiple charge states and singly charged multimers of molecular [MH]⁺ ions over the entire record range, based on MALDI methods. The technique is tested using calibration mixtures and pooled serum quality control samples acquired along with clinical study data. The described automated procedure improves the analysis and dimension reduction of MS data for comparative proteomics applications. Copyright © 2009 John Wiley & Sons, Ltd.