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Ersilia Nigro Marialuisa Formato Giuseppina Crescente Aurora Daniele 《Molecules (Basel, Switzerland)》2021,26(9)
Cannabis sativa L. is a source of over 150 active compounds known as phytocannabinoids that are receiving renewed interest due to their diverse pharmacologic activities. Indeed, phytocannabinoids mimic the endogenous bioactive endocannabinoids effects through activation of CB1 and CB2 receptors widely described in the central nervous system and peripheral tissues. All phytocannabinoids have been studied for their protective actions towards different biological mechanisms, including inflammation, immune response, oxidative stress that, altogether, result in an inhibitory activity against the carcinogenesis. The role of the endocannabinoid system is not yet completely clear in cancer, but several studies indicate that cannabinoid receptors and endogenous ligands are overexpressed in different tumor tissues. Recently, in vitro and in vivo evidence support the effectiveness of phytocannabinoids against various cancer types, in terms of proliferation, metastasis, and angiogenesis, actions partially due to their ability to regulate signaling pathways critical for cell growth and survival. The aim of this review was to report the current knowledge about the action of phytocannabinoids from Cannabis sativa L. against cancer initiation and progression with a specific regard to brain, breast, colorectal, and lung cancer as well as their possible use in the therapies. We will also report the known molecular mechanisms responsible for such positive effects. Finally, we will describe the actual therapeutic options for Cannabis sativa L. and the ongoing clinical trials. 相似文献
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J. C. Fabris S. V. B. Gonçalves P. E. de Souza 《General Relativity and Gravitation》2002,34(12):2111-2126
The mass power spectrum for a Universe dominated by the Chaplygin gas is evaluated numerically from scales of the order of the Hubble horizon to 100 Mpc. The results are compared with a pure baryonic Universe and a cosmological constant model. In all three cases, the spectrum increases with k, the wavenumber of the perturbations. The slope of the spectrum is higher for the baryonic model and smaller for the cosmological constant model, the Chaplygin gas interpolating these two models. The results are analyzed in terms of the sound velocity of the Chaplygin gas and the moment the Universe begins to accelerate. 相似文献
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Daniele Cauzzi Roberto Giordano Enrico Sappa Antonio Tiripicchio Marisa Tiripicchio Camellini 《Journal of Cluster Science》1993,4(3):279-296
The title complex (complex1) was the first alkyne-substituted triruthenium dihydrido cluster to be reported and was characterized by spectroscopy as a triangular cluster with the alkyne parallel to a Ru-Ru edge. Recently, we have found that1 is a key intermediate in the homogeneous hydrogenation of diphenylacetylene catalyzed by tetrahedral Ru4 and FeRu3 clusters. Since the discovery of1, a great number of complexes with alkynes parallel to a cluster edge have been reported; at present this is the more common bonding mode for alkynes on trinuclear clusters. The structural features of1 allow a comparison with those of other ruthenium-containing derivatives and help to draw suggestions of the role of1 in hydrogenation catalysis. 相似文献
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In this paper the neo-classical economic Solow-Swan model (1956) has been improved replacing its Malthusian manpower law with
the Verhulst (logistic) one. The relevant ordinary differential equation for the ratio capital/work has been then integrated
in closed form via the Hypergeometric function2
F
1. The logistic growth injection for the manpower is detected to induce a more slow dynamics onto the Solow-Swan system, which
keeps its stability. Increasing developments are displayed as the technologic progress rises. Further sceneries are tested
and the congruence of the new solution with the classical one is shown switching to zero the selflimitation coefficent in
the logistic law.
Research supported by MURST grant:Metodi matematici in economia 相似文献
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Ilda Abe Rafael E. de Ges Jos L. Fabris Hypolito J. Kalinowski Mrcia Müller Meire C. Fugihara Rosane Falate Barbara W. Diesel Ricardo C. Kamikawachi Carmen L. Barbosa 《Optics and Lasers in Engineering》2003,39(5-6):537-548
In this work, we report production and modelling of both Bragg gratings and rocking filters in high birefringence fibre optics. Bragg gratings are produced by UV (257.0 nm) external interferometric exposition of a frequency-doubled Ar+ ion laser, whereas for rocking filters formation the visible Ar+ ion laser lines in 488.0 and 514.5 nm are used in an internal method. The spectral characteristics due to the birefringence properties are studied through numerical methods and experimental techniques. The spectral responsivity of the structures under temperature changes and stress application is presented. 相似文献
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Infinite dimensional duality and applications 总被引:2,自引:0,他引:2
Patrizia Daniele Sofia Giuffrè Giovanna Idone Antonino Maugeri 《Mathematische Annalen》2007,339(1):221-239
The usual duality theory cannot be applied to infinite dimensional problems because the underlying constraint set mostly has
an empty interior and the constraints are possibly nonlinear. In this paper we present an infinite dimensional nonlinear duality
theory obtained by using new separation theorems based on the notion of quasi-relative interior, which, in all the concrete
problems considered, is nonempty. We apply this theory to solve the until now unsolved problem of finding, in the infinite
dimensional case, the Lagrange multipliers associated to optimization problems or to variational inequalities. As an example,
we find the Lagrange multiplier associated to a general elastic–plastic torsion problem. 相似文献
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In this paper we develop the fundamental elements and results of a new theory of regular functions of one quaternionic variable. The theory we describe follows a classical idea of Cullen, but we use a more geometric formulation to show that it is possible to build a rather complete theory. Our theory allows us to extend some important results for polynomials in the quaternionic variable to the case of power series. 相似文献