Solid-state interactions and drug release of teicoplanin in binary combinations with peracetylated α-, β-, and γ-cyclodextrins

Triacetyl α-cyclodextrin, triacetyl β-cyclodextrin and triacetyl γ-cyclodextrin were tested as possible hydrophobic carriers to prolong the release of hydrophilic teicoplanin (TCP). Physical–chemical characterization of individual components, drug-carrier physical mixtures at 0.5, 0.67 and 0.75 mass fraction of carrier, and the respective interaction products by kneading or evaporative crystallization under microwave irradiation was carried out using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). In vitro drug release in pH 7.4 phosphate buffer at 37 °C was determined by intrinsic dissolution rate (IDR) measurements on non disintegrating compressed discs. Solid-state interactions of TCP with triacetyl α-cyclodextrin by evaporative crystallization and kneading and with triacetyl β-cyclodextrin by evaporative crystallization (probably resulting in carrier amorphization) were demonstrated. The role of carrier hydrophobicity, carrier mass fraction and preparation method of solid drug-carrier combinations on solid-state drug-carrier interactions and slowing down of TCP release was assessed. Modulation of drug release can be achieved using TCP-triacetyl γ-cyclodextrin combinations at 0.5 mass fraction of carrier.     

Effect of gravitational radiation upon electromagnetic waves in a dispersive medium

We show that linearized gravitational radiation produces fluctuations in intensity and position of a distant source if the ray travels in a dispersive medium. The effect, however, depends upon the nongeodesic character of the ray and does not occur in an electrostatic plasma. When the index of refraction n is greater than unity a Cerenkov type resonance produces scintillation proportional to D _O ^3/2 (D _O being the distance of the source) and a dancing proportional to D _O ^1/2 if, instead, n<1 the scintillation behaves like D _O and the dancing does not diverge as D _O . The calculation is performed in detail for a random and isotropic spectrum of gravitational waves W(). This effect allows one to set an upper limit to W() at the frequency at which the fluctuations are observed, but for the rarified interstellar and intergalactic plasmas these limits are not very interesting.     

Classical solutions of CPn non linear σ -models; an algebraic geometrical description

The classical SO (3)-invariant σ-model and its suitably generalized versions are studied from the geometrical point of view. Known mathematical results concerning harmonic and holomorphic maps of a Riemann surface into the n-dimensional complex projective space are briefly reviewed. These are used to give a classification of classical solutions (both instantons and a certain subclass of unstable solutions) of $\text{C}$Pⁿ models and to study the properties of their energy spectrum.     

Balanced superprojective varieties

We first review the definition of superprojective spaces from the functor-of-points perspective. We derive the relation between superprojective spaces and supercosets in the framework of the theory of sheaves. As an application of the geometry of superprojective spaces, we extend Donaldson’s definition of balanced manifolds to supermanifolds and we derive the new conditions of a balanced supermanifold. We apply the construction to superpoints viewed as submanifolds of superprojective spaces. We conclude with a list of open issues and interesting problems that can be addressed in the present context.     

Investigation of the thermal and structural behaviour of diclofenac sodium-sugar ester surfactant systems

Sugar esters (SEs) have a wide range of hydrophilic-lipophilic balance (HLB) values (1–16) and hence can be applied as surfactants or as solubility or penetration enhancers. They can be used for hot melt technology and solvent method which are frequently applied techniques to preparation of solid dispersions. In this study drug-SE products were prepared by physical mixing, melt technology and solvent methods. The products were investigated by DSC, X-ray powder diffraction and dissolution tests. Diclofenac sodium (DS) as model drug and two SEs, P1670 (HLB=16) and S970 (HLB=9) were used for the preparation of the products. DSC curves revealed considerable melting range and enthalpy decreases for the DS-SE products. The dissolved drug molecules broke down the structures of the SEs but were not built into the crystalline phase of the carrier. The melt technology led to a solid dispersion while in the case of the solvent methods the DS was in molecularly dispersed form which resulted in faster dissolution. The drug release was influenced by the structures resulting from the various treatments, by the HLB and by the gel-forming behaviour of the SEs.     

Emergy Based Analysis of Italian Electricity Production System

The continuously increasing demand for electric power together with the demand of environmental friendly technologies require a deep acknowledgement of the directions to give to electric power production in order to satisfy both necessities. The aim of this work is to evaluate the sustainability of Italian electric system by using the emergy function, a methodology developed in the early80s by Odum, and its correlated indices. Emergy is a thermodynamic based function that calculates all the fluxes of energy requested to obtain a product going backward to the solar energy invested. We analyzed all the inputs concurring to the yield of electricity taking into account not only the final phases of the production but also all the sources and materials that had been necessary for the system to operate. We have performed a wide analysis of all the different types of production focusing on thermoelectric sector. We have obtained not only a thermodynamic analysis of electricity production but also an evaluation of the sustainability of the entire process and a scenario for a correct exploitation of resources. This revised version was published online in July 2006 with corrections to the Cover Date.     

On the energy spectrum and parameter spaces of classicalCP n models

It is known that a large class of smooth solutions ofCP ⁿ models can be constructed starting from holomorphic maps of an algebraic curve into complex projective spaces. Here we apply results from algebraic geometry to describe the energy spectrum and the parameter spaces for such models.Work partially supported by Gruppo Nazionale di Fisica Matematica, CNR and Gruppo Nazionale per le Strutture Algebriche e Geometriche e Applicazioni, CNR     

Algebraic classification of ℂP n instanton solutions

The finite condition for two-dimensional ℂP ⁿ models is discussed noting that one can impose boundary conditions such that the domain of the field is a compact Riemann surface S _g. Holomorphic maps φ: S _g →ℂP ⁿ give finite energy solutions of the classical field equations, which are classified according to standard methods of algebraic geometry. The moduli problem is discussed in detail for S _g =ℂP ¹=S ².     

Characterization of silver sulfadiazine-loaded solid lipid nanoparticles by thermal analysis

The aim of this study is the solid-state characterization of solid lipid nanoparticles (SLN) based on Compritol^® 888 (C888) and Lutrol^® F68 (F68), loaded with silver sulfadiazine (AgSD), used to develop sponge-like dressings to treat chronic skin ulcers such as decubitis and leg ulcers. Silver compounds like AgSD, in fact, are used to prevent and/or to treat wound colonization that could impair healing, also in the case of antibiotic-resistant bacteria. Thermal analysis, with support from powder X-ray diffractometry and Fourier transform infrared spectroscopy, is used to characterize lipid and drug bulk, unloaded and drug-loaded SLN. In particular, differential scanning calorimetry is used to investigate the degree of crystallinity and the solid-state modification of lipid, two parameters correlated to drug incorporation and drug release rates. The solid-state characterization demonstrates AgSD entrapment in C888 as a core enclosed into F68 shell. AgSD SLN are also stored at different temperatures 25 and 37 °C, respectively, to study the effect of storage conditions, that induce an increase of the lipid crystallinity index correlated to drug release from the lipid matrix.     

A geometrical description of local and global anomalies

The general topological framework for testing the possible occurrence of anomalies in gauge theories can be constructed in terms of the theory of group actions on line bundles through the introduction of a suitable group cohomology. In this Letter, we generalize this construction in such a way that it can be applied to a larger class of theories, allowing for a noncontractible configuration space and a nonconnected ‘gauge’ group. This construction find applications to the problem of the lifts of principal group actions. As a physical application, we compare the mechanisms of the anomalies cancelation in gauge and string theories, through a geometrical splitting of local and global anomalies.