排序方式: 共有16条查询结果,搜索用时 15 毫秒
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M.C. Lafarie-Frenot M. Gigliotti L. Olivier J. Verdu J. Cinquin 《Polymer Degradation and Stability》2010,95(6):965-974
The present paper presents a review of the main activities carried out within the context of the COMEDI research program, a joint collaboration involving three research teams focusing on the thermo-oxidation behaviour of composite materials at high temperatures.The scientific aim of the COMEDI research program was to better identify the link between the physical mechanisms involved in thermo-oxidation phenomena: oxygen reaction-diffusion, chemical shrinkage strain/stress, degradation at different scales and to provide tools for predicting the thermo-oxidation behaviour of composite materials under thermo-oxidative environments including damage onset.This aim was accomplished by investigating experimentally the thermo-oxidation behaviour of pure resin samples - both industrial and “model” materials - and by interpreting the results by a coupled reaction-diffusion-mechanics multiphysics model.A dedicated numerical model tool has been developed and implemented into the ABAQUS® finite element commercial software. This tool was employed to simulate the thermo-oxidative behaviour of a fibre-matrix microscopic representative composite cell.Finally, the model predictions for the composite have been validated by comparing the experimental and the simulated local matrix shrinkage displacements and the mass loss of composite specimens. 相似文献
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Marco Gigliotti Frédéric Jacquemin Jérôme Molimard Alain Vautrin 《Macromolecular Symposia》2007,247(1):199-210
Summary : The present paper is concerned with the modelling and the simulation of hygrothermal deformation of composite laminates. The temperature and moisture fields are established by employing the Fick's law for transient and cyclical environmental conditions, then the Classical Plate Theory (CLT) adapted for taking into account such conditions is applied. The hygrothermoelastic law of the composite is supposed to be constant but the diffusion coefficients depend on the temperature. The paper shows the ability of the model to handle complex environmental loading, close to service conditions. Finally, a model of plate with moderate rotations is introduced to predict the nonlinear deformations of unsymmetric plates under temperature and moisture cycling conditions. 相似文献
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Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE 总被引:1,自引:0,他引:1
Laura Mercolini Carmelina Iannello Ferdinando Nicoletti Maria Augusta Raggi 《Talanta》2009,80(1):279-2918
Diazepam is frequently used as an adjuvant during antidepressant therapy. Recently, some studies have suggested that the treatment with benzodiazepines could have different efficacy in depressed patients as opposed to non-depressed ones. To clarify the matter, a study is currently underway, regarding the drug metabolism in rats. In order to obtain a more complete and significant set of data, the main diazepam metabolites have also been considered, namely: nordiazepam, temazepam and oxazepam. A feasible and reliable HPLC method has been developed for the simultaneous determination of these compounds in plasma and brain tissue of rats. The method has been applied to “normal” rats and to genetic rat models of depression in order to estimate drug metabolism in different breeds. Analyte separation was achieved on a C8 reversed phase column using an acidic phosphate buffer/acetonitrile mixture as the mobile phase. The detection wavelength was 238 nm. An original sample pre-treatment, based on solid-phase extraction (SPE) was developed in order to eliminate endogenous interference, using only 250 μL of matrix (brain homogenate or plasma) for a complete analysis. The method has been validated with good results in terms of precision, extraction yield, sensitivity, selectivity and accuracy on both matrices and has been successfully applied to samples from some rats subjected to the preliminary study. The obtained data will hopefully contribute to the clarification of possible differences between depressed and non-depressed subjects with respect to benzodiazepine biotransformation. 相似文献
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Pastorino L Erokhina S Soumetz FC Bianchini P Konovalov O Diaspro A Ruggiero C Erokhin V 《Journal of colloid and interface science》2011,357(1):56-62
The protein collagen is the major component of connective tissue and it is involved in many biological functions. Its degradation is at the basis of different pathological processes. The up-regulated expression of matrix metalloproteinases and the down-regulated expression of their inhibitors are the causes for such degradation. The aim of this work was to evaluate the possibility to fabricate collagen based containers for drug encapsulation and release by cellular demand by the action of matrix metalloproteinases. In present work collagen type I based microcapsules were fabricated by means of the layer-by-layer assembly of oppositely charged collagen and poly (stirene sulfonate) onto colloidal particles, followed by removal of the cores to obtain hollow microcapsules. The process of shell growth on planar supports was monitored by quartz crystal microbalance. X-ray reflectivity measurements were carried out at the solid/water interface to study the interaction of matrix metalloproteinase 1 with LbL films of collagen. The morphology of hollow capsules was characterized by scanning electron microscopy, and compared to that of capsules exposed to the matrix metalloproteinase 1. Finally the matrix metalloproteinase 1 mediated permeability of capsules variation was studied by Confocal Laser Scanning Microscopy. The results demonstrated the possibility to fabricate a drug delivery system where the release of the drug is dependent on the biochemistry of the pathological state. 相似文献
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Meccanica - The paper focuses on the deformation behaviour of isotropic and orthotropic plates subjected to bending moments distributed along the edges, two couples M0 and ?M0 along the... 相似文献
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Bishop S Azuma RE Buchmann L Chen AA Chatterjee ML D'Auria JM Engel S Gigliotti D Greife U Hernanz M Hunter D Hussein A Hutcheon D Jewett C José J King J Kubono S Laird AM Lamey M Lewis R Liu W Michimasa S Olin A Ottewell D Parker PD Rogers JG Strieder F Wrede C 《Physical review letters》2003,90(16):162501
The 21Na(p,gamma)22Mg reaction is expected to play an important role in the nucleosynthesis of 22Na in oxygen-neon novae. The decay of 22Na leads to the emission of a characteristic 1.275 MeV gamma-ray line. This report provides the first direct measurement of the rate of this reaction using a radioactive 21Na beam, and discusses its astrophysical implications. The energy of the important state was measured to be E(c.m.)=205.7+/-0.5 keV with a resonance strength omegagamma=1.03+/-0.16(stat)+/-0.14(sys) meV. 相似文献