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2.
M. Berthelot 《Fresenius' Journal of Analytical Chemistry》1899,38(4):243-245
Ohne Zusammenfassung 相似文献
3.
The electroreduction of 1–3 diphenylpropenone (chalcone) in anhydrous DMF, on a mercury pool, leads to a new trimer compound or some classical hydrodimers. The former was obtained with TBA+ as a counter ion and its configuration completely solved. The latter were obtained in the presence of Li+, Cr3+ or Mn2+ and their structures were determined unambiguously for the first time. In all cases the influence of the counter ion on the distribution of products was reported. 相似文献
4.
Yasri A Berthelot D Gijsen H Thielemans T Marichal P Engels M Hoflack J 《Journal of chemical information and computer sciences》2004,44(6):2199-2206
REALISIS is a software system for reagent selection, library design, and profiling, developed to fit the workflow of bench chemists and medicinal chemists. Designed to be portable, the software offers a comprehensive graphical user interface and rapid, integrated functionalities required for reagent retrieval and filtering, product enumeration, and library profiling. REALISIS is component-based, consisting of four main modules: reagent searching; reagent filtering; library enumeration; and library profiling. Each module allows the chemist to access specific functionalities and diverse filtering and profiling mechanisms. By implementing the entire process of reagent selection, library design, and profiling and by integrating all the necessary functionalities for this process, REALISIS cuts the time required to design combinatorial and noncombinatorial libraries from several days to a few hours. 相似文献
5.
Andr Darchen Pascal Berthelot Claude Vaccher M. Nazareth Viana Michel Debaert Jean Louis Burgot 《Journal of heterocyclic chemistry》1986,23(5):1603-1607
Two-electron reduction of some substituted 1,2-dithiole-3-thiones 1 followed by alkylation of the dianionic intermediates leads through electrosynthesis to mixture of Z and E isomers of the corresponding substituted alkyl-(3-thioalkyl)-2-propenedithioates 2, 3 in satisfactory yield. The structure of those products was established by 13C and 1H nmr and mass spectroscopy. The isomers ratios were determined by nmr spectroscopy. 相似文献
6.
Ch. Berthelot G. Carraro V. Verdingh 《Journal of Radioanalytical and Nuclear Chemistry》1980,60(2):443-451
A large number of toxic elements, including Th and U, in Scheldt and NBS river sediments, have been determined non-destructively
by high energy photon activation. The length of irradiation varies between 1.5 hours for short lived-nuclides and 7–18 hours
for long lived-nuclides. The induced activities are measured using a single open-ended coaxial Ge(Li) detector and the photopeak
integrations are calculated using the total peak area method and the Cutipie computer program after substraction of the intrinsic
background of the detector from each spectrum (Angela program). The photonuclear reactions and the best detection limits for
36 elements are indicated. 相似文献
7.
8.
A simple and efficient method for monobromination of aromatic amines predominantly in the para position is reported. Tetrabutylammonium tribromide is used at 20° and yields of parabromoanilines are higher than 90%. 相似文献
9.
ABSTRACT: The reaction of tetrabutylammonium tribromide (TBABr3) with mono and disubstituted alkynes in methanol at 20°C leads to the formation of mainly the corresponding α,α-dibromo, β,β-dimethoxyalkane and the E-(α,β)-dibromoalkene. The additions are faster using sonication. 相似文献
10.
Bruno Oyallon Marie Brachet-Botineau Cdric Log Thomas Robert Stphane Bach Sajida Ibrahim William Raoul Ccile Croix Pascal Berthelot Jean Guillon Noël Pinaud Fabrice Gouilleux Marie-Claude Viaud-Massuard Caroline Denevault-Sabourin 《Molecules (Basel, Switzerland)》2021,26(4)
Proviral integration site for Moloney murine leukemia virus (Pim)-1/2 kinase overexpression has been identified in a variety of hematologic (e.g., multiple myeloma or acute myeloid leukemia (AML)) and solid (e.g., colorectal carcinoma) tumors, playing a key role in cancer progression, metastasis, and drug resistance, and is linked to poor prognosis. These kinases are thus considered interesting targets in oncology. We report herein the design, synthesis, structure–activity relationships (SAR) and in vitro evaluations of new quinoxaline derivatives, acting as dual Pim1/2 inhibitors. Two lead compounds (5c and 5e) were then identified, as potent submicromolar Pim-1 and Pim-2 inhibitors. These molecules were also able to inhibit the growth of the two human cell lines, MV4-11 (AML) and HCT-116 (colorectal carcinoma), expressing high endogenous levels of Pim-1/2 kinases. 相似文献