Investigation and comparison of pristine/doped BN,AlN, and CN nanotubes as drug delivery systems for Tegafur drug: a theoretical study

Structural Chemistry - In this work, the potential of BN, AlN, and CN nanotubes as the drug delivery systems of Tegafur (TG) was investigated by the density functional theory (DFT). The doping...     

ZnBr2 catalyzed domino Knoevenagel-hetero-Diels–Alder reaction: An efficient route to polycyclic thiopyranoindol annulated [3,4-c]quinolone derivatives

Various novel polycyclic thiopyranoindol annulated [3,4-c]quinolone derivatives were synthesized via domino Knoevenagel-hetero-Diels–Alder reactions of indoline-2-thions and novel N-acrylated anthranilaldehydes in refluxing ethanol as a solvent in the presence of 20 mol% ZnBr₂ as a Lewis acid catalyst. All reactions proceed with high yields with excellent regio- and stereoselectivity.     

Electrospun metal‐organic framework/polyacrylonitrile composite nanofibrous mat as a microsorbent for the extraction of tetracycline residue in human blood plasma

A new composite nanofiber of polyacrylonitrile doped with copper benzene‐1,3,5‐tricarboxylate metal‐organic framework was fabricated by electrospinning and used as a microsorbent in the solid‐phase extraction of trace tetracycline. The chemical structure of the adsorbent was studied by X‐ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, Brunauer–Emmett–Teller surface area analysis, and Barrett‐Joyner‐Halenda pore size and volume analysis techniques. The significant parameters of the method including desorption solvent kind and volume, adsorbent mass, pH, and salt percentage were investigated. At the optimized conditions, the linear range was 8–1000 μg/L with a determination coefficient (R²) of 0.9954. The limits of detection and quantification were 2.40 and 8.00 μg/L, respectively. The inter‐ and intraday precisions were 4.7 and 3.4%, respectively. The developed extraction method was followed by high‐performance liquid chromatography and applied for the determination of tetracycline in human blood plasma, and good relative recoveries (97.3‐104.5%) were obtained.     

Preparation of fluoxetine by multiple flow processing steps

Microflow technology is established as a modern and fashionable tool in synthetic organic chemistry, bringing great improvement and potential, on account of a series of advantages over flask methods. The study presented here focuses on the application of flow chemistry process in performing an efficient multiple step syntheses of (±)-fluoxetine as an alternative to conventional synthetic methods, and one of the few examples of total synthesis accomplished by flow technique.     

Heck reactions using segmented flow conditions

Various Heck couplings have been carried out using segmented flow conditions to accelerate the reactions. Aryl iodides and aryl bromides as well as anilines in diazonium-type Heck reactions have been used successfully.