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Harikishore Amaravadhi Chong Sherilyn Shi Min Ragunathan Priya Bates Roderick W. Grüber Gerhard 《Molecular diversity》2021,25(1):517-524
Molecular Diversity - Mycobacteria have shown enormous resilience to survive and persist by remodeling and altering metabolic requirements. Under stringent conditions or exposure to drugs,... 相似文献
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Yerukala Suneetha Bommana Naresh Kumar Yapati Harinath D. Harikishore Kumar Reddy Kalluru Seshaiah 《Mikrochimica acta》2012,176(1-2):169-176
We have developed a new method for solid phase extraction (SPE) and preconcentration of trace amounts of cadmium and zinc using cross linked chitosan that was functionalized with 2-aminopyridine-3-carboxy acid. Analytical parameters, sample pH, effect of flow rate, sample volume, and concentration of eluent on column SPE were investigated. The effect of matrix ions on the recovery of cadmium and zinc has been investigated and were found not to interfere with preconcentration. Under the optimum experimental conditions, the preconcentration factors for Cd(II) and Zn(II) were found to be 90. The two elements were quantified via atomic absorption spectrometry. The detection limits for cadmium and zinc are 21 and 65?ng?L?1, respectively. The method was evaluated by analyzing a certified reference material (NIST 1643e; water) and has been successfully applied to the analysis of cadmium and zinc in environmental water samples. Figure
A simple and sensitive solid phase extraction method for the preconcentration of Cd(II) and Zn(II) in environmental samples using cross linked chitosan functionalized with 2-aminopyridine-3-carboxylic acid was developed. The metal ions enriched by functionalized chitosan were eluted with acid and determined by AAS. 相似文献
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Adam Hotra Priya Ragunathan Pearly Shuyi Ng Pattarakiat Seankongsuk Amaravadhi Harikishore Jickky Palmae Sarathy Wuan‐Geok Saw Umayal Lakshmanan Patcharaporn Sae‐Lao Nitin Pal Kalia Joon Shin Revathy Kalyanasundaram Sivaraj Anbarasu Krupakar Parthasarathy Chaudhari Namrata Pradeep Harshyaa Makhija Peter Drge Anders Poulsen Jocelyn Hui Ling Tan Kevin Pethe Thomas Dick Roderick W. Bates Gerhard Grüber 《Angewandte Chemie (International ed. in English)》2020,59(32):13295-13304
The F1FO‐ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clinical target. A mycobacterium‐specific loop of the enzyme's rotary γ subunit plays a role in the coupling of ATP synthesis within the enzyme complex. We report the discovery of a novel antimycobacterial, termed GaMF1, that targets this γ subunit loop. Biochemical and NMR studies show that GaMF1 inhibits ATP synthase activity by binding to the loop. GaMF1 is bactericidal and is active against multidrug‐ as well as bedaquiline‐resistant strains. Chemistry efforts on the scaffold revealed a dynamic structure activity relationship and delivered analogues with nanomolar potencies. Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay. These results suggest that GaMF1 presents an attractive lead for the discovery of a novel class of anti‐tuberculosis F‐ATP synthase inhibitors. 相似文献
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Adam Hotra Priya Ragunathan Pearly Shuyi Ng Pattarakiat Seankongsuk Amaravadhi Harikishore Jickky Palmae Sarathy Wuan-Geok Saw Umayal Lakshmanan Patcharaporn Sae-Lao Nitin Pal Kalia Joon Shin Revathy Kalyanasundaram Sivaraj Anbarasu Krupakar Parthasarathy Chaudhari Namrata Pradeep Harshyaa Makhija Peter Dröge Anders Poulsen Jocelyn Hui Ling Tan Kevin Pethe Thomas Dick Roderick W. Bates Gerhard Grüber 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(32):13397-13406
The F1FO-ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clinical target. A mycobacterium-specific loop of the enzyme's rotary γ subunit plays a role in the coupling of ATP synthesis within the enzyme complex. We report the discovery of a novel antimycobacterial, termed GaMF1, that targets this γ subunit loop. Biochemical and NMR studies show that GaMF1 inhibits ATP synthase activity by binding to the loop. GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains. Chemistry efforts on the scaffold revealed a dynamic structure activity relationship and delivered analogues with nanomolar potencies. Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay. These results suggest that GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors. 相似文献
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G Jayakrishna P Harikishore C V Rao D Gunasekar A Blond B Bodo 《Chemical & pharmaceutical bulletin》2001,49(12):1555-1557
Two new 2'-oxygenated flavones, 5,2',6'-trihydroxy-7-methoxyflavone (3) and skullcapflavone I 2'-O-beta-D-(4"-E-cinnamyl) glucopyranoside (5), together with three known flavones, 7-O-methylwogonin (1), skullcapflavone I (2) and skullcapflavone I 2'-O-beta-D-glucopyranoside (4) were isolated from the whole plant of Andrographis elongata, and the structures were elucidated by FAB-MS and one- and two-dimensional (1D- and 2D)-NMR spectral studies including 1H-1H correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC) and rotating frame Overhauser enhancement spectroscopy (ROESY) experiments, and chemical studies. 相似文献
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