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THE MOLECULAR WEIGHT OF HAEMATOPORPHYRIN DERIVATIVE, ITS GEL COLUMN FRACTIONS and SOME OF ITS COMPONENTS IN AQUEOUS SOLUTION 总被引:1,自引:0,他引:1
A. Geoffrey Swincer A. David Ward Geoffrey J. Howlett 《Photochemistry and photobiology》1985,41(1):47-50
Abstract— The average molecular weights of haematoporphyrin derivative (HPD), the fractions of HPD that can he obtained by gel chromatography and of purified haematoporphyrin and protoporphyrin in aqueous solution have been determined by ultracentrifugation. The results show that HPD contains polymeric material with the excluded fraction from the gel column (HPD aggregate) having an average molecular weight of greater than 20000. The two remaining gel column fractions of HPD have lower molecular weights and their similarity indicates that these fractions do not separate because of molecular weight differences. Purified haematoporphyrin has a comparatively low molecular weight in aqueous solution but the data is not capable of discriminating between monomer, dimer or slightly higher oligomer. In contrast, protoporphyrin sediments to the bottom of the centrifuge tube under the conditions of sedimentation equilibrium indicating that it has an average molecular weight considerably greater than that of HPD aggregate. 相似文献
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Michael I. Bruce Trevor W. Hambley MichaeL R. Snow A.Geoffrey Swincer 《Journal of organometallic chemistry》1982,235(1):105-112
The title complex was obtained from the adduct of C2(CN)4 and Rh(CCPh)-(CO)(PPh3)2 by simple substitution of CO in refluxing acetonitrile. Crystals of the complex are orthorhombic, with a 10.058(2), b 20.008(4), c 21.594(5) Å, space group P212121, Z 4. The rhodium has approximate trigonal bipyramidal coordination, with apical NCMe and C2Ph ligands: RhC2Ph, 1.939(18); RhC(olefinic), 2.151, 2.157(19); RhN, 2.051(16); RhP, 2.377, 2.397(6) Å. 相似文献
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P. A. Cowled I. J. Forbes A. G. Swincer V. C. Trenerry A. D. Ward 《Photochemistry and photobiology》1985,41(4):445-451
Abstract— The separation and fractionation of some of the components of haematoporphyrin derivative by chemical extraction, gel chromatography and membrane filtration are described. The composition of the various fractions and the purity of the individual porphyrins can be assessed by high performance liquid chromatography. Porphyrins containing vinyl side chains show an unusual ability to form relatively stable aggregates of apparently high molecular weight. The effect is most pronounced with protoporphyrin and is not observed with haematoporphyrin which has no vinyl side chains. These aggregates can be separated by gel chromatography or membrane filtration from non (or less) aggregated material. The aggregates show greater in vitro cytotoxicity than the other fractions. 相似文献
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Michael I. Bruce Trevor W. Hambley Michael R. Snow A.Geoffrey Swincer 《Journal of organometallic chemistry》1984,273(3):361-376
Reactions between MX(PPh3)2(η-C5H5) (M = Ru, X = Cl; M = Os, X = Br) and 2-CH2CHC6H4PPh2 afford Ph2)(η-C5H5); the Os complex is obtained in two isomeric forms. The X-ray structure of the major isomer shows the CC double bond (OsC, 2.214, 2.195 Å; CC, 1.57 Å) is almost coplanar with the OsBr vector, with the terminal C cis to Br; the minor isomer is assumed to have the alternative, more sterically congested conformation, with the β-C cis to Br. The chlororuthenium complex reacts with NaOMe/MeOH to give the corresponding hydrido complex, which also exists as two isomers in solution; reaction of this complex with CS2 gives the expected dithio acid derivative Ph2)(η-C5H5), together with small amounts of a complex assumed to be Ph2](η-C5H5). The X-ray structure of the major product reveals an unusual η3-S2C mode of coordination of the dithio acid fragment (RuS, 2.418, 2.426(1) Å; RuC 2.175(4) Å). Crystals of OsBr(η2-CH2CHC6H4P)Ph2)( η-C5H5) are monoclinic, space group P21/n, with a 12.696(2), b 21.719(6), c 15.929(3) Å, β 79.77(2)°, Z = 8; 2867 data (I > 2.5σ(I)) were refined to R = 0.040, Rw = 0.044. Crystals of Ph2)(η-C5H5) are orthorhombic, space group Pbca, with a 8.921(2), b 15.982(9), c 32.216(5) Å, Z = 8; 1685 data (I > 2.5σ(I)) were refined to R = 0.027, Rw = 0.030. 相似文献
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