气相色谱法测定桂利嗪片含量

桂利嗪(Cinnarizinum C_(26)H_(28)N_2)片剂,是一种血管扩张药,常用于脑动脉硬化、脑栓塞、脑血管痉挛等症。中国药典收载的桂利嗪片剂含量测定为非水滴定法,该法不但操作复杂,费时、费事,而且对鼻咽均有刺激反应。用气相色谱法测定桂利嗪,目前在国内外尚未见报道,本法操作简便,结果稳定可靠。     

气相色谱法检测去甲斑蝥素片含量

GC method for direct quantitative determination of Norcantharidi in tablets was developed.The condi-tions for determination were:FID detector at 210℃;column:2%OV-17 Chromosorb W(AW- DMCS 80～100 mesh(2m×3mm i.d),temperature at 165℃; injector at 210℃. Vanillin as internal standard. Theresponse was linear between 0.2mg/mL and 1.6mg/mL。The average recovery was 100.03/with a coeffi-cient of variation of 0. 97%。This method is proved to be highly sensitive,good reproducible and simple forpre-treatment.     

云南蕊木生物碱的研究

云南蕊木(Kopsia offcinalis Tsiang et P.T.Li)为夹竹桃科(Apocynaceae)柯蒲木属(Kopsia)植物,是云南西双版纳地区傣族民间的一个传统草药,用于治疗麻风、咽喉炎、风湿骨痛、四肢麻木和水肿等疾病.我们分析了这一植物的化学成分;从根及茎皮提出的总生物碱,药理试验显示镇痛作用.我们共分出10个吲哚型生物碱,通过光谱分析和化学工作,鉴定出四个为已知生物碱kopsinine(1)、kopgamine(2)、eburnamine(3)、perivine(4);三个为