In this paper, two problems from the molecular sciences are addressed: the enumeration of fullerene-type isomers and the alignment
of biosequences. We report on two algorithms dealing with these problems both of which are based on the well-known and widely
used Divide&Conquer principle. In other words, our algorithms attack the original problems by associating with them an appropriate
number of much simpler problems whose solutions can be “glued together” to yield solutions of the original, rather complex
tasks. The considerable improvements achieved this way exemplify that the present day molecular sciences offer many worthwhile
opportunities for the effective use of fundamental algorithmic principles and architectures. 相似文献
The Stevens rearrangement of a nitrile-stabilized ammonium ylide is the key step of a very short and practical synthesis of the phenanthroindolizine alkaloid (±)-tylophorine. The method requires only five linear steps and is devoid of any protecting group manipulations. 相似文献
An animalic note : The first total synthesis of the all‐cis nupharamine 2 , an alkaloid from beaver castoreum, is based on the stereoselective domino Mannich–Michael reaction of N‐galactosylfurylaldimine to give 1 (Piv=pivaloyl), subsequent conjugate cuprate addition, and stereoselective protonation of the enolate. These reactions are all controlled by the carbohydrate. Protonation of the enolate after cleavage of the auxiliary leads to epimer 3 .