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排序方式: 共有77条查询结果,搜索用时 15 毫秒
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Kharchenko PV Alekseyenko AA Schwartz YB Minoda A Riddle NC Ernst J Sabo PJ Larschan E Gorchakov AA Gu T Linder-Basso D Plachetka A Shanower G Tolstorukov MY Luquette LJ Xi R Jung YL Park RW Bishop EP Canfield TK Sandstrom R Thurman RE MacAlpine DM Stamatoyannopoulos JA Kellis M Elgin SC Kuroda MI Pirrotta V Karpen GH Park PJ 《Nature》2011,471(7339):480-485
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function. 相似文献
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C.J. Batty S.F. Biagi M. Blecher R. Kunselman R.A.J. Riddle B.L. Roberts J.D. Davies G.J. Pyle G.T.A. Squier D.M. Asbury M. Leon 《Nuclear Physics A》1978,296(3):361-372
The attenuation due to the E2 nuclear resonance effect has been measured in hadronic atoms using pions with 111Cd and 112Cd, and for kaons with 122Sn. Energies of the relevant X-ray and γ-ray transitions and of the X-ray cascade intensities have also been measured so as to give a self-consistent set of information. The results are found to be in very good agreement with theoretical calculations. 相似文献
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We have examined the basic assumptions leading to optimized performance of small photo-acoustic resonators. Previous attempts at miniaturizing photo-acoustic systems have found the loading of the microphone on the cavity to be insignificant. We have shown theoretically and tested experimentally the fact that the microphone loading can have a dramatic effect on the resonator behavior. Treatment of the pressure and volume velocity of the sound waves as analogs of voltage and current facilitates the use of standard electrical engineering techniques and leads to techniques that enable one to efficiently optimize the impedance match between the cavity and the microphone. PACS 43.35.Ud; 43.20.Ks; 43.20.Mv 相似文献
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C.J. Batty S.F. Biagi M. Blecher S.D. Hoath R.A.J. Riddle B.L. Roberts J.D. Davies G.J. Pyle G.T.A. Squier D.M. Asbury A.S. Clough 《Physics letters. [Part B]》1978,76(1):44-46
The Doppler broadened 26Mg* decay gamma peak hasma peak has been observed in coincidence with stopped kaons in an Al target. The results are compared with predictions based on single-nucleon absorption of the kaon. 相似文献
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Duygu İNCİ 《应用有机金属化学》2020,34(12):e6016
NOO-type tridentate Schiff base, N-salicylidene-2-aminobenzoic acid, (H2L), and its ternary Cu (II) complex containing H2L Schiff base and 4,7-dimethyl-1,10-phenanthroline (4,7-dmphen), [Cu(4,7-dmphen)(H2L)]27H2O, have been synthesized and characterized by CHN analysis, ESI-MS, FTIR, and single-crystal X-ray diffraction techniques. The interaction of alone H2L Schiff base ligand and ternary Cu (II) complex with biomacramolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy. The experimental results indicate that H2L Schiff base ligand and ternary Cu (II) complex bind to CT-DNA by means of a moderate intercalation mode. Furthermore, the fluorescence quenching mechanism between H2L Schiff base ligand and ternary Cu (II) complex with BSA possesses a static quenching process. Radical scavenging activity of H2L Schiff base ligand and ternary Cu (II) complex was measured in terms of EC50, using the DPPH and H2O2 methods. Biomacromolecule interactions and scavenging activity studies revealed that ternary Cu (II) complex yielded better results than H2L Schiff base ligand alone. 相似文献
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Riddle WR Li R Fitzpatrick JM DonLevy SC Dawant BM Price RR 《Magnetic resonance imaging》2004,22(6):769-777
Image registration is the process of establishing spatial correspondence between two images or between two image volumes. Registration can be achieved by rigid, elastic, or a combination of rigid and elastic transforms that attempt to bring the two images into coincidence. A rigid transform accounts for differences in positioning and an elastic transform describes deformations due to differences in tissue properties, temporal changes due to growth or atrophy, or differences between individuals. Deformation-based morphometry uses the resulting deformation fields from these transforms to evaluate differences between the images being registered. Three methods of registration were evaluated: rigid (affine) transformation, elastic optical flow transformation, and elastic spline transformation. All three methods produce vector deformation fields that map each point in one image to a point in the other image. A 12-color map of the transformation Jacobian was used to represent local volume changes. Using the three registration methods, color-mapped Jacobians were determined using a simulated three-dimensional block with known translation, rotation, expansion, contraction, and intensity modulations. Color-coded Jacobians were also generated for experimentally measured magnetic resonance image volumes of water-filled balloons and 7-year-old twin boys. Color-coded Jacobians overlaid on anatomical images provide a convenient method to identify regional tissue expansion and contraction. 相似文献