Forthrightly monitoring ferroptosis induced by endoplasmic reticulum stresses through fluorescence lifetime imaging of microviscosity increases with a specific rotor

To test the hypothesis that the microviscosity changes of Endoplasmic Reticulum(ER) can be a useful indicator of ferroptosis promoted by ER Stresses(ERS), a new ER targeting viscosity rotor, L-Vis-1 was developed and applied in the quantitation of viscosity by FLIM imaging in live cells. The FLIM imaging exhibited an excellent resolution almost as good as the corresponding confocal imaging, more significantly, during ferroptosis processes promoted by different types of ERS, the viscosity increas...     

Pattern transition and regulation in a subthalamopallidal network under electromagnetic effect

Although the significant roles of magnetic induction and electromagnetic radiation in the neural system have been widely studied, their influence on Parkinson's disease (PD) has yet to be well explored. By virtue of the magnetic flux variable, this paper studies the transition of firing patterns induced by magnetic induction and the regulation effect of external magnetic radiation on the firing activities of the subthalamopallidal network in basal ganglia. We find: (i) The network reproduces five typical waveforms corresponding to the severity of symptoms: weak cluster, episodic, continuous cluster, episodic, and continuous wave. (ii) Magnetic induction is a double-edged sword for the treatment of PD. Although the increase of magnetic coefficient may lead the physiological firing activity to transfer to pathological firing activity, it also can regulate the pathological intensity firing activity with excessive β-band power transferring to the physiological firing pattern with weak β-band power. (iii) External magnetic radiation could inhibit continuous tremulous firing and β-band power of subthalamic nucleus (STN), which means the severity of symptoms weakened. Especially, the bi-parameter plane of the regulation region shows that a short pulse period of magnetic radiation and a medium level of pulse percentage can well regulate pathological oscillation. This work helps to understand the firing activity of the subthalamopallidal network under electromagnetic effect. It may also provide insights into the mechanisms behind the electromagnetic therapy of PD-related firing activity.     

SINGULAR PERTURBATION OF BOUNDARY VALUE PROBLEM FOR NONLINEAR HIGHER ORDER ORDINARY DIFFERENTIAL EQUATIONS INVOLVING TWO SMALL PARAMETERS

The singularly perturbed boundary value problem for nonlinear higher order ordinary differential equation involving two small parameters has been considered. Under appropriate assumptions, for the three cases:ε/μ2→0(μ→0),μ2/ε→0 (ε→0) andε=μ2, the uniformly valid asymptotic solution is obtained by using the expansion method of two small parameters and the theory of differential inequality.     

PURIFICATION OF L-METHIONINE AND N-ACETYL-D-METHIONINE FROM THE MIXTURE OF ENZYMATICALLY DEACYLATED N-ACETYL-DL-METHIONINE

1. INTRODUCTION Methionine, namely 2-amido-4-thiomethyl butyric acid with a structure of CH3SCH2CH2CHCOOH, is one of the essential amino acids and has two natural enantionmers, D and L-methionine. The mixture of L- and D-isomers can be used as analeptics or nutritive additives to maintain the equilibrium of amino acids of feed [1,2]. L-methionine can release active methyl and accelerate the synthesis of choline, which further speeds up the conversion of the lipid accumulated in liv…     

EXTENSION OF MULTIPLIERS AND INJECTIVE HILBERT MODULES

The author studies the problem whether a multiplier of a hereditary C^*-subalgebra B of a C^*-algebra A can be extended to a multiplier of A. One related problem is the Hahn-Banach extension theorem for Hilbert modules over C^*-algebras. It is shown that every self-dual Hilbert module over W^*-algebra or an injective C^*-algebra is injective.     

PURE STATE APPROACH TO $C(X)×_\alpha Z_n$

ＰＵＲＥ ＳＴＡＴＥ ＡＰＰＲＯＡＣＨ ＴＯ Ｃ（ｘ）_αＺ_nＬＩＢＩＮＧＲＥＮ；ＬＩＮＱＩＮＧ（ＩｎｓｔｉｔｕｔｅｏｆＭａｔｈｅｍａｔｉｃｓ，ＡｃａｄｅｍｉａＳｉｎｉｃａ，Ｂｅｉｊｉｎｇ１０００８０，Ｃｈｉｎａ．Ｐｒｏｊｅｃｔｓｕｐｐｏｒｔｅｄｂｙｔｈ?..     

CONVERGENCE ON RANDOMLY TRIMMED SUMS WITH A DEPENDENT SAMPLE

§１．ＩｎｔｒｏｄｕｃｔｉｏｎａｎｄＲｅｓｕｌｔｓＬｅｔ｛Ｘｎ，ｎ１｝ｂｅａｓｅｑｕｅｎｃｅｏｆｒａｎｄｏｍｖａｒｉａｂｌｅｓｗｉｔｈａｃｏｍｍｏｎｄｉｓｔｒｉｂｕｔｉｏｎｆｕｎｃｔｉｏｎＦ（ｘ）ａｎｄｌｅｔＸｎ１Ｘｎ２…Ｘｎｎｂｅｔｈｅｏｒ...     

PERMANENCE AND GLOBAL STABILITY TO A NONAUTONOMOUS NONLINEAR DISCRETE SINGLE SPECIES SYSTEM

In this paper,we study some permanence and global stability to a nonau- tonomous nonlinear discrete single species system,and obtain some sufficient condition of global stability to the system.     

Augmented Spinor Space

In this paper, based on the Pauli matrices, a notion of augmented spinor space is introduced, and a uniqueness of such augmented spinor space of rank n is proved. It may be expected that this new notion of spaces can be used in mathematical physics and geometry.     

LIE ALGEBRA K$(n,\mu _j,m)$ OF CARTAN TYPE OF CHARACTERISTIC p=2

Let $K(n,\mu _j,m),n=2r+1$,denote the Lie algebra of characteristic p=2,which is defined in [4].In the paper the restrictability of $K(n,\mu _j,m)$ is discussed and it is proved that,when $r\equiv 1(mod 2)$ and $r>1,I(ad f)=n+1$ if and only if $0\neq f \in $. Then the invariance of some filtrations of K(n,\mu,m) and the condition of isomorphism of K(n,\mu _i,m) and K(n',\mu _j ^',m') are obtained.Besides,the generators and the derivation algebra of K(n,\mu _i,m) are discussed.The results also hold,when $r\equiv 0 (mod 2)$ and r>0.