半岛城市群产业结构与竞争力的偏离份额分析

本文以山东省为参照系,运用偏离—份额分析模型对半岛城市群市2000—2004年、2004—2008年的三次产业结构进行了分析,在研究半岛城市群发展现状的基础上,针对各产业的优势和劣势,提出各产业调整和优化的发展建议。     

渤海海洋资源可持续利用研究

通过分析渤海的资源现状,发现造成渤海资源不可持续的主要原因在于人为因素,提出了加大力度治理污染,改善渤海生态环境;在可持续发展层面,从生态原则考虑资源的可持续利用,如土著种及生态位原则、建设海洋牧场原则、休渔期与渔具优化原则、生态补偿原则、公众参与原则,为政府有关部门提供决策参考依据。     

14种钯抗癌络合物初步筛选的荧光法研究

本文提出抗癌络合物初步筛选的荧光新方法,对所合成的14种钯(Ⅱ)/邻菲咯啉/氨基酸/氯离子(Pd(Ⅱ)/phen/aa/Cl)络合物作为非顺铂抗癌药物进行了体外筛选及结合作用研究,发现荧光筛选法结果与其它如甲烯蓝试管法、苔盼蓝染料排斥法基本一致,其中络合物[Pd(phen)(lys)]Cl,[Pd(phen)(arg)]Cl,[Pd(phen)(pro)]Cl对小鼠S-180瘤株抑瘤率分别为56％,50％,48％,这同它们与DNA结合常数7.96×10~6,4.52×10~6,1.0×10~6顺序相一致,表明荧光筛选法具有一定可靠性,并且荧光法具有操作简便、耗费低廉、周期较短等优点,适于抗癌络合物的初步筛选。     

新型抗癌配合物的研究——Ⅰ钯(Ⅱ)—邻二氮菲—氨基酸配合物的抗癌活性

本文合成了三种新的钯(Ⅰ)—邻二氮菲—氨基酸配合物〔Pd(phen)AA〕C1, AA为L-赖氨酸,L-脯氨酸,L-精氨酸.用元素分析、红外光谱等方法对配合物进行表征,用细胞染料排斥法、动物实验考察了配合物的抗癌活性.结果表明,以上三种配合物均具有不同程度的抗癌活性,且较顺铂优越之处在于毒性很低,L-脯氨酸和L-精氨酸配合物的溶解度较好.     

Preliminary Fluorimetric Screening of Fourteen Palladium Complexes as Potential Antitumor Agents

Making use of the fact that the combination of a drug substance with DNA may inhibit the duplication, synthesis and proliferation of DNA and the consistency of the in vivo and in vitro interactions, the authors worked out a preliminary screening method for testing complex agents as potential antitumor drugs using ethidium bromide as a fluorescence probe. In this report, the method was applied for in vitro testing fourteen synthesized palladium(Ⅱ)/phenanthroline/amino acid/chloride complexes as potential non-platinum antitumor agents. The fluorimetric screening method was compared with methylene blue tube test and trypan blue dye exclusion assay. All three methods gave agreeable results. Among the complexes tested, [Pd(phen)(lys)]Cl, [Pd(phen)(arg)]Cl and [Pd(phen)(pro)]Cl showed antineoplastic ratios for animal tumor S-180 56%, 50% and 48%, respectively, in accordance with the order of their binding constants with DNA, 7.96×10~6, 4.52×10~6 and 1.0×10~6, respectively. The test results show that fluor