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Those suffering from a severe to profound sensorineural hearing loss can obtain substantial benefit from a cochlear implant prosthesis. An electrode array implanted in the inner ear stimulates auditory nerve fibers by direct injection of electrical current. A major limitation of today's technology is the imprecise control of intracochlear current flow, particularly the relatively wide spread of neural excitation. A better understanding of the intracochlear electrical fields is, therefore, required. This paper analyzes the structure of intracochlear potential measurements in relation to both the subject's anatomy and to the properties of the electrode array. An electrically equivalent network is proposed, composed of small lumped circuits for the interface impedance and for the cochlear tissues. The numerical methods required to estimate the model parameters from high-quality electrical potential recordings are developed. Finally, some models are presented for subjects wearing a Clarion CII device with a HiFocus electrode and discussed in terms of model reliability.  相似文献   
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Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright 1999 John Wiley & Sons, Ltd.  相似文献   
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In a very short period of time, the Internet has risen from being viewed as a peculiarity of the defence and academic community of the late sixties to become a significant component of many of our working and home lives. The possible impact of this technology has the futurists talking of the collapse of national borders, the bypass of tax systems and traditional commerce and the emancipation of the individual from the clutches of government, corporations and the boundaries of culture, gender and physical constraints. Most users' experience of the Internet is through browser software and applications such as e-mail, World Wide Web, Newsgroups and media plug-ins. Beneath this glossy, graphical, multimedia world exists the architectural and protocol components which have enabled the Internet evolution to reach into so many parts of everday life in such a short time. The aim of this paper is to outline some of these components, their characteristics and limitations, and their ongoing development to address those limitations and add new capabilities. Even though an overview of Internet protocols is included in this paper, basic knowledge of Internet technology is assumed.  相似文献   
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This paper considers the problem of initializing the wavelet packet transform when the analog input x(t) is either bandlimited or else is piecewise polynomial on the dyadic intervals. This is accomplished by the construction of certain prefilter sequences that are applied to the samples {xk|xk=x(kT)} (T is the sampling period). In the piecewise polynomial case, the prefilter sequences are computed with the aid of the interpolatory graphical display algorithm (IGDA), which is used to compute the so-called incremental moment functions of the scaling function φ(t) on the dyadic points. The moments of φ(t) are also employed  相似文献   
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正兼容液体介质的压力传感器通常可简化医疗系统的设计和降低其成本某些OEM医疗设备要求具备能在凝露或液体环境下使用的压力传感器。兼容液体介质的压力传感器,可免受液体侵害,且无需额外采取防护,减少了与此相关的设计复杂性和成本。为OEM医疗设备应用选择最佳  相似文献   
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