Application of neural networks and machine learning in networkdesign

Communication network design is becoming increasingly complex, involving making networks more usable, affordable, and reliable. To help with this, we have proposed an expert network designer (END) for configuring, modeling, simulating, and evaluating large structured computer networks, employing artificial intelligence, knowledge representation, and network simulation tools. We present a neural network/knowledge acquisition machine-learning approach to improve the END's efficiency in solving the network design problem and to extend its scope to acquire new networking technologies, learn new network design techniques, and update the specifications of existing technologies     

Multi-User MIMO Mobile CDMA Uplink System Employing Turbo Coding and Joint Detection Through a Multipath Rayleigh Fading Channel

In this paper, a generalized multiple-input multiple-output (MIMO) antenna system that can be fitted to the uplink of a wireless communication system is considered for the general case of multi-user. At the transmitter, the information bits are Turbo coded, then interleaved and passed through a serial-to-parallel converter. The channel is assumed bad urban suffering from multipath Rayleigh fading resulting in inter-symbol and multiple access interferences (ISI and MAI). At the front-end of the receiver, a number of receiving antennas are used followed by a joint multi-user estimator based on the Minimum Mean Square Error Block Linear Equalizer (MMSE-BLE).Computer simulations demonstrate a significant performance improvement in both single user and multi-user cases.This paper depends in parts on that presented at the 11th European Wireless Conference, Cyprus, Nicosia, pp. 187–192, April 2005. Yasmine A. Fahmy was born in Guiza, Egypt, on June 4, 1976. She received the B.Sc., M.Sc. and Ph.D. degrees in Communication and Electronics engineering from Cairo University, Egypt on 1999, 2001 and 2005 respectively. She is presently an assistant professor at Cairo University, Egypt. Her current field of interest is wireless communication and channel estimation. Hebat-Allah M. Mourad received her B.Sc., M. Sc. and Ph.D. degrees in electrical communication engineering from Cairo University, Egypt, in 1983, 1987 and 1994 respectively. Since 1983, she has been with the Department of Electronics and Communications, Faculty of Engineering, Cairo University, and is currently associate professor there. Her research interests include optical fiber communications, mobile and satellite communications. Emad K. Al-Hussaini received his B.Sc degree in Electrical Communication Engineering from Ain-Shams University, Cairo, Egypt, in 1964 and his M.Sc and Ph.D. degrees from Cairo University, Giza, Egypt, in 1974 and 1977, respectively. From 1964 to 1970, he was with the General Egyptian Aeroorganization. Since 1970, he has been with the Department of Electronics and Communications, Faculty of Engineering, Cairo University, and is currently professor there. He was a research fellow at Imperial College, London, UK, and at the Moore School of Electrical Engineering, University of Pennsylvania, Philadelphia, PA, USA, in the academic years 1976/1977 and 1981/1982, respectively. In 1990, he received the Egyptian national encouragement award for outstanding engineering research. He has written several papers for technical international journals and conferences. His research interests include signal processing, fading channel communication, modulation, and cellular mobile radio systems. Dr Al-Hussaini is a senior member of IEEE. He is listed in Marquis Whos Who in the World and in the IBC (International Biographical Center, Cambridge) for outstanding people of the 20th century.     

Performance and buffering requirements of Internet protocols overATM ABR and UBR services

ATM networks are quickly being adopted as backbones over various parts of the Internet. This article studies the dynamics and performance of the TCP/IP protocol over the ABR and UBR services of ATM networks. Specifically the buffering requirements in the ATM switches as well as the ATM edge devices. It is shown that with a good switch algorithm, ABR pushes congestion to the edges of the ATM network while UBR leaves it inside the ATM portion. As a result, the switch ABR buffer requirement for zero-packet-loss high-throughput TCP transmission is a sublinear function of the number of TCP connections     

Symmetrical and Asymmetrical Bisphosphonate Esters. Synthesis, Selective Hydrolysis, and Isomerization

Two simple and efficient one-pot procedures for the synthesis of a series of α-branched N-heterocycle-substituted methane-1,1-bisphosphonates are outlined. In the first method, the parent halosubstrates were reacted with cyanomethylphosphonate followed by reaction with dialkyl phosphonates to give asymmetrical or symmetrical bisphosphonates (BPs). In the second approach, the same halocompounds were reacted with tetraethyl methyl-1,1-bisphosphonate to give the requisite BPs. Partial and complete hydrolysis of the prepared BPs were also investigated. The products contain functional groups advantageous for further synthetic modification as structural units for coupling with the drug.     

Polarographic activity of the arylhydrazones of α-cyanoketones as a criterion of their acidity

The polarographic behaviour of phenylhydrazonomesoxalonitrile (2) and ethyl phenylhydrazonomesoxalonitrile (3) as well as pK′ and pK_a values are reported for a series of arylhydrazones of α-cyanoketones.     

TreeDock: a tool for protein docking based on minimizing van der Waals energies

Predicting protein-protein and protein-ligand docking remains one of the challenging topics of structural biology. The main problems are (i) to reliably estimate the binding free energies of docked states, (ii) to enumerate possible docking orientations at a high resolution, and (iii) to consider mobility of the docking surfaces and structural rearrangements upon interaction. Here we present a novel algorithm, TreeDock, that addresses the enumeration problem in a rigid-body docking search. By representing molecules as multidimensional binary search trees and by exploring a sufficient number of docking orientations such that two chosen atoms, one from each molecule, are always in contact, TreeDock is able to explore all clash-free orientations at very fine resolution in a reasonable amount of time. Due to the speed of the program, many contact pairs can be examined to search partial or complete surface areas. The deterministic systematic search of TreeDock is in contrast to most other docking programs that use stochastic searches such as Monte Carlo or simulated annealing methods. At this point, we have used the Lennard-Jones potential as the only scoring function and show that this can predict the correct docked conformation for a number of protein-protein and protein-ligand complexes. The program is most powerful if some information is known about the location of binding faces from NMR chemical-shift perturbation studies, orientation information from residual dipolar coupling, or mutational screening. The approach has the potential to include docking-site mobility by performing molecular dynamics or other randomization methods of the docking site and docking families to families of structures. The performance of the algorithm is demonstrated by docking three complexes of immunoglobulin superfamily domains, CD2 to CD58, the V(alpha) domain of a T-cell receptor to its V(beta) domain, and a T-cell receptor to a pMHC complex as well as a small molecule inhibitor to a phosphatase.     

IDENTIFICATION OF THE PROTON ACCEPTOR OF SCHIFF BASE DEPROTONATION IN BACTERIORHODOPSIN: A FOURIER-TRANSFORM-INFRARED STUDY OF THE MUTANT ASP85 → GLU IN ITS NATURAL LIPID ENVIRONMENT

Abstract— In order to assign the proton acceptor for Schiff base deprotonation in bacteriorhodopsin to a specific Asp residue, the photoreaction of the Asp85 → Glu mutant, as expressed in Halobacterium sp . GRB, was investigated by static low-temperature and time-resolved infrared difference spec-troscopy. Measurements were also performed on the mutant protein labeled with [4-¹³C]Asp which allowed discrimination between Asp and Glu residues. 14,15-di¹³C-retinal was incorporated to distinguish amide-II absorbance changes from changes of the ethylenic mode of the chromophore. In agreement with earlier UV-VIS measurements, our data show that from both the 540 and 610 nm species present in a pH-dependent equilibrium, intermediates similar to K and L can be formed. The 14 ms time-resolved spectrum of the 540 nm species shows that a glutamic acid becomes protonated in the M-like intermediate, whereas the comparable difference spectrum of the 610 nm species demonstrates that in the initial state a glutamic acid is already protonated. In conjunction with earlier observations of protonation of an Asp residue in wild-type M, the data provide direct evidence that the proton acceptor in the deprotonation reaction of the Schiff base is Asp85.     

Optimized Green Extraction of Polyphenols from Cassia javanica L. Petals for Their Application in Sunflower Oil: Anticancer and Antioxidant Properties

The total phenolic content (TPC) from Cassia javanica L. petals were extracted using ethanolic solvent extraction at concentrations ranging from 0 to 90% and an SCF-CO₂ co-solvent at various pressures. Ultrasound-assisted extraction parameters were optimized using response surface methodology (RSM). Antioxidant and anticancer properties of total phenols were assessed. An SCF-CO₂ co-solvent extract was nano-encapsulated and applied to sunflower oil without the addition of an antioxidant. The results indicated that the best treatment for retaining TPC and total flavonoids content (TFC) was SCF-CO₂ co-solvent followed by the ultrasound and ethanolic extraction procedures. Additionally, the best antioxidant activity by β-carotene/linoleic acid and DPPH free radical-scavenging test systems was observed by SCF-CO₂ co-solvent then ultrasound and ethanolic extraction methods. SCF-CO₂ co-solvent recorded the highest inhibition % for PC3 (76.20%) and MCF7 (98.70%) and the lowest IC₅₀ value for PC3 (145 µ/mL) and MCF7 (96 µ/mL). It was discovered that fortifying sunflower oil with SCF-CO₂ co-solvent nanoparticles had a beneficial effect on free fatty acids and peroxide levels. The SCF-CO₂ method was finally found to be superior and could be used in large-scale processing.