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1.
Ryoko Chiba Ayako Ogasawara Teppei Kubo Hiroyuki Yamazaki Masuo Umino Yoichi Ishizuka 《Analytical sciences》2003,19(5):785-789
A column-switching high-performance liquid chromatographic method with fluorescence detection was developed for the simultaneous determination of four benzamide-type anti-psychotic drugs: sulpiride, tiapride, sultopride and metoclopramide in human serum. In this method, a TSKgel Super-ODS column was used as an analytical column, and a TSKgel G 2000SW was prepared as a pretreatment column. Under the optimized analytical conditions, four benzamide-type anti-psychotic drugs were eluted within 18 min. The detection limits (S/N = 3) for sulpiride, tiapride, sultopride and metoclopramide are 1 ng/ml, 4 ng/ml, 2 ng/ml and 0.5 ng/ml, respectively. Finally, the method was applied to the determination of sulpiride in human serum samples obtained after a single oral dose of sulpiride. 相似文献
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Masumi Torii Yuki Hitora Hikaru Kato Yuhei Koyanagi Teppei Kawahara Fitje Losung Remy E.P. Mangindaan Sachiko Tsukamoto 《Tetrahedron》2018,74(52):7516-7521
Four new sulfonated serinol derivatives, siladenoserinols M–P (1–4), were isolated from a tunicate of the family Didemnidae collected in Indonesia. Their chemical structures were elucidated by the interpretation of NMR and mass spectroscopic data. Two of them (2 and 4) were revealed to be disulfonate serinol derivatives, and the others were monosulfonates. Siladenoserinols A (5) and B (6), which we previously isolated from the same tunicate, inhibited the p53–Hdm2 interaction with an IC50 value of 2.0?μM. However, 1–4 did not inhibit the activity. The result suggested that the acetyl group in the bicyclic ketal unit and/or the glycerophospholipid moiety in 5 and 6 were responsible for the inhibition of the p53–Hdm2 interaction. 相似文献
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We consider nonsynchronous sampling of parameterized stochastic regression models, which contain stochastic differential equations. Constructing a quasi-likelihood function, we prove that the quasi-maximum likelihood estimator and the Bayes type estimator are consistent and asymptotically mixed normal when the sampling frequency of the nonsynchronous data becomes large. 相似文献
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Teppei Yoshioka Md Zahangir Alam Tomonari Ogata Takamasa Nonaka Seiji Kurihara 《Liquid crystals》2004,31(9):1285-1291
Several chiral azobenzene compounds having different chiral substituents were synthesized. A cholesteric phase was induced by mixing each chiral azobenzene compound with a host non-chiral nematic liquid crystal (E44). The helical twisting power (HTP) as well as the change in HTP by trans-cis photoisomerization of the chiral azobenzene compound was dependent on the structure of the chiral substituents. A compensated nematic phase was induced by combination of E44, a chiral azobenzene compound and a non-photochromic chiral compound. Reversible switching between the compensated nematic phase and cholesteric phase was brought about by trans-cis photoisomerization of the chiral azobenzene compound in the liquid crystalline systems. An azobenzene compound substituted with a menthyl group showed the highest efficiency as the trigger for the switching; this efficiency was related to the compactness of the chiral group substituted within the azobenzene core moiety. 相似文献
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Shibata T Ito S Doe M Tanaka R Hashimoto H Kinoshita I Yano S Nishioka T 《Dalton transactions (Cambridge, England : 2003)》2011,40(25):6778-6784
Nickel complexes having acetylated glucopyranosyl group incorporated N-heterocyclic carbene (NHC) ligands with methyl or benzyl groups as an N-substituent exhibit two kinds of dynamic behaviours in solution (1)H NMR spectroscopy. One of the dynamic behaviours is attributed to the anti- and syn-rotamers, which occur by the rotation of the unsymmetrical NHC ligands around the axes of the Ni-C bonds. The other is attributed to the diastereomers of the syn-rotamers, which occur by opposite rotation of the imidazolylidene rings and the chiral carbohydrate group incorporated into the NHC ligands. Crystallographic analysis of the nickel complex having the NHC ligand with acetylated glucopyranosyl and benzyl groups as N-substituents showed CH-π interaction between the glucopyranosyl unit of each NHC ligand and the phenyl ring of the other NHC ligand in the complex in the solid state. 相似文献
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One of the dominant types of interactions between host and guest molecules is hydrogen-bonding, and these interactions can work selectively for a guest molecule. Here, we demonstrate a metal-organic framework (MOF) having both hydrogen-bonding donor and acceptor sites that are quite effective for selective sorption. The MOF selectively interacts with hydroxylic guests in contrast to aprotic hydrogen-bonding guests and shows a sorption selectivity for protic H(2)O, MeOH, and EtOH guests. Notably, this is the first compound that shows complete selectivity in adsorption not for MeCN and MeCHO but for EtOH, which has similar fundamental properties except for its proticity. 相似文献
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Tsuyoshi Kijima Yu Nagatomo Hirokatsu Takemoto Masafumi Uota Daisuke Fujikawa Yuzo Sekiya Teppei Kishishita Makoto Shimoda Takumi Yoshimura Hideya Kawasaki Go Sakai 《Advanced functional materials》2009,19(4):545-553
Nanohole‐structured single‐crystalline Pt nanosheets have been synthesized by the borohydride reduction of Na2PtCl6 confined to the lyotropic liquid crystals (LLCs) of polyoxyethylene (20) sorbitan monooleate (Tween 80) with or without nonaethylene‐glycol (C12EO9). The Pt nanosheets of around 4–10 nm in central thickness and up to 500 nm or above in diameter have a number of hexagonal‐shaped nanoholes ∼1.8 nm wide. High‐resolution electron microscope images of the nanosheets showed atomic fringes with a spacing of 0.22 nm indicating that the nanosheets are crystallographically continuous through the nanoholed and non‐holed areas. The inner‐angle distributions for the hexagonal nanoholes indicate that the six sides of the nanoholes are walled with each two Pt (111), Pt (1 1) and Pt (010) planes. The formation mechanism of nanoholed Pt nanosheets is discussed on the basis of structural and compositional data for the resulting solids and their precursory LLCs, with the aid of similar nanohole growth observed for a Tween 80 free but oleic acid‐incorporated system. It is also demonstrated that the nanoholed Pt nanostructures loaded on carbon exhibit fairly high electrocatalytic activity for oxygen reduction reaction and a high performance as a cathode material for polymer‐electrolyte fuel cells, along with their extremely high thermostability revealed through the effect of electron‐irradiation. 相似文献
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Highly Efficient Dehydrogenative Coupling of Hydrosilanes with Amines or Amides Using Supported Gold Nanoparticles 下载免费PDF全文
Dr. Takato Mitsudome Teppei Urayama Dr. Zen Maeno Dr. Tomoo Mizugaki Prof. Dr. Koichiro Jitsukawa Prof. Dr. Kiyotomi Kaneda 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(8):3202-3205
Hydroxyapatite‐supported gold nanoparticles (Au/HAP) can act as a highly active and reusable catalyst for the coupling of hydrosilanes with amines under mild conditions. Various silylamines can be selectively obtained from diverse combinations of equimolar amounts of hydrosilanes with amines including less reactive bulky hydrosilanes. This study also highlights the applicability of Au/HAP to the selective synthesis of silylamides through the coupling of hydrosilanes with amides, demonstrating the first example of an efficient heterogeneous catalyst. Moreover, Au/HAP shows high reusability and applicability for gram‐scale synthesis. 相似文献
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A variety of N-confused tetraphenylporphyrin rhodium complexes were synthesized, and their structures and physical properties were investigated. Depending on the reaction conditions, the rhodium(I), -(III), and -(IV) complexes were produced, which exemplified the versatile coordination mode of N-confused porphyrin ligands. 相似文献