Simultaneous high-performance liquid chromatographic determination of antazoline phosphate and tetrahydrozoline hydrochloride in ophthalmic solution

A method for the determination of 2-[(N-phenyl)benzylaminomethyl]-2-imidazoline X H3PO4 (antazoline phosphate) and 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline X HCl (tetrahydrozoline hydrochloride) in ophthalmic solution is described. The pharmaceutical preparation is analysed directly by reversed-phase ion-pair high-performance liquid chromatography and the method is very rapid, selective and simple.     

A two dimensional Lagrangian model with extended supersymmetry and infinitely many constants of motion

The reduction of the supersymmetric gradedSU(2|1) /S(U ₂×U ₁) -model is discussed. If no extra constraint is imposed, one gets a set of two coupled equations (involving two scalar superfields) which generalizes the supersymmetric sine-Gordon equation. It is shown that these equations, which can be derived by a supersymmetric Lagrangian, reproduce in the bosonic limit the reduced version of theO(4) -model (Pohlmeyer, Lund Regge, Getmanov model). Moreover the associate linear set and an infinite set of local conservation laws for this new supersymmetric model are exhibited. It turns out that, beyond the spinorial charge which generates the supersymmetry transformations, another unexpected spinorial charge is conserved; then the model appears to be invariant underN=2 extended supersymmetry.     

A Sensitivity-Based Design Space Exploration Methodology for Embedded Systems

In this paper, we propose a system-level design methodology for the efficient exploration of the architectural parameters of the memory sub-systems, from the energy-delay joint perspective. The aim is to find the best configuration of the memory hierarchy without performing the exhaustive analysis of the parameters space. The target system architecture includes the processor, separated instruction and data caches, the main memory, and the system buses. To achieve a fast convergence toward the near-optimal configuration, the proposed methodology adopts an iterative local-search algorithm based on the sensitivity analysis of the cost function with respect to the tuning parameters of the memory sub-system architecture. The exploration strategy is based on the Energy-Delay Product (EDP) metric taking into consideration both performance and energy constraints. The effectiveness of the proposed methodology has been demonstrated through the design space exploration of a real-world case study: the optimization of the memory hierarchy of a MicroSPARC2-based system executing the set of Mediabench benchmarks for multimedia applications. Experimental results have shown an optimization speedup of 2 orders of magnitude with respect to the full search approach, while the near-optimal system-level configuration is characterized by a distance from the optimal full search configuration in the range of 2%.     

Polymer supported calixarene derivative useful for solid-phase synthesis application

A calix[4]arene derivative has been anchored to carboxyl CPG and TentaGel supports by an easily cleavable ester bond and DMT groups allow a simple loading evaluation via UV-vis spectroscopy. The loading of the calixarene on TentaGel resin has also been estimated by HR-MAS NMR experiments. The potential of the polymer supported calixarenes (9 and 10) in solid phase synthesis has been tested by condensation of four thymine nucleotide units onto the upper rim of the calix[4]arene skeleton.     

An Electrostatic Charge Partitioning Model for the Dissociation of Protein Complexes in the Gas Phase

Electrosprayed multi-protein complexes can be dissociated by collisional activation in the gas phase. Typically, these processes follow a mechanism whereby a single subunit gets ejected with a disproportionately high amount of charge relative to its mass. This asymmetric behavior suggests that the departing subunit undergoes some degree of unfolding prior to being separated from the residual complex. These structural changes occur concomitantly with charge (proton) transfer towards the subunit that is being unraveled. Charge accumulation takes place up to the point where the subunit loses physical contact with the residual complex. This work develops a simple electrostatic model for studying the relationship between conformational changes and charge enrichment during collisional activation. Folded subunits are described as spheres that carry continuum surface charge. The unfolded chain is envisioned as random coil bead string. Simulations are guided by the principle that the system will adopt the charge configuration with the lowest potential energy for any backbone conformation. A finite-difference gradient algorithm is used to determine the charge on each subunit throughout the dissociation process. Both dimeric and tetrameric protein complexes are investigated. The model reproduces the occurrence of asymmetric charge partitioning for dissociation events that are preceded by subunit unfolding. Quantitative comparisons of experimental MS/MS data with model predictions yield estimates of the structural changes that occur during collisional activation. Our findings suggest that subunit separation can occur over a wide range of scission point structures that correspond to different degrees of unfolding.     

Experimental evidence of mounting grooves and serration patterns on fin lines characteristics

In this paper, the mounting grooves and serration patterns of fin line circuits are investigated experimentally. Our measurements show that the short-circuit ended mounting grooves degrade seriously the insertion loss of fin lines at the low frequencies of the band. The open ended mounting grooves are found better for fin lines applications and measurements. An improvement of 0.7 dB is observed over the whole band, when the serration patterns of the fin line are placed into the open-ended mounting grooves. These results can be used for measuring the losses and for designing transitions or other fin line circuits.     

Testability analysis and behavioral testing of the Hopfield neuralparadigm

Testability analysis and test pattern generation for neural architectures can be performed at a very high abstraction level on the computational paradigm. In this paper, we consider the case of Hopfield's networks, as the simplest example of networks with feedback loops. A behavioral error model based on finite-state machines (FSM's) is introduced. Conditions for controllability, observability and global testability are derived to verify errors excitation and propagation to outputs. The proposed behavioral test pattern generator creates the minimum length test sequence for any digital implementation     

ALADIN: a multilevel testability analyzer for VLSI system design

In order to cope with tomorrow's challenges in the microelectronic market, the reliability of the first phases of the design process must be improved. The possibility of applying techniques for testability analysis at these abstract design levels can considerably help in achieving this goal, reducing at the same time system design costs. In this paper we introduce a novel approach for the application of functional testability at system design level and demonstrate the possibility of its application in an industrial environment. Testability conditions referring to both regular and irregular topologies have been defined, formalized and inserted into the knowledge base of the expert system, ALADIN. This tool operates as a testability analyzer able to identify critical areas for testability in designs whose functional modules and local interconnections are known and described in standard VHDL. The architecture of the tool has been defined in order to satisfy the users' requirements including the integrability into a standard CAD design flow through standard I/O interfaces. Then its application to both a regular and an irregular topology are presented in order to show on real examples which testability conditions apply, and how the tool operates in order to reach the testability assessment. From these industrial case studies, figures of merit are derived from which it is possible to evaluate the importance of the application of such a methodology to system level design