全文获取类型
收费全文 | 5280篇 |
免费 | 350篇 |
国内免费 | 21篇 |
专业分类
化学 | 3879篇 |
晶体学 | 14篇 |
力学 | 111篇 |
数学 | 666篇 |
物理学 | 663篇 |
无线电 | 318篇 |
出版年
2023年 | 65篇 |
2022年 | 48篇 |
2021年 | 99篇 |
2020年 | 119篇 |
2019年 | 125篇 |
2018年 | 85篇 |
2017年 | 76篇 |
2016年 | 240篇 |
2015年 | 218篇 |
2014年 | 217篇 |
2013年 | 310篇 |
2012年 | 380篇 |
2011年 | 402篇 |
2010年 | 265篇 |
2009年 | 228篇 |
2008年 | 325篇 |
2007年 | 286篇 |
2006年 | 294篇 |
2005年 | 291篇 |
2004年 | 254篇 |
2003年 | 176篇 |
2002年 | 199篇 |
2001年 | 98篇 |
2000年 | 83篇 |
1999年 | 78篇 |
1998年 | 62篇 |
1997年 | 88篇 |
1996年 | 70篇 |
1995年 | 68篇 |
1994年 | 46篇 |
1993年 | 50篇 |
1992年 | 32篇 |
1991年 | 24篇 |
1990年 | 20篇 |
1989年 | 21篇 |
1988年 | 14篇 |
1987年 | 15篇 |
1986年 | 13篇 |
1985年 | 10篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1981年 | 11篇 |
1979年 | 7篇 |
1978年 | 14篇 |
1977年 | 13篇 |
1976年 | 7篇 |
1975年 | 8篇 |
1974年 | 14篇 |
1973年 | 14篇 |
排序方式: 共有5651条查询结果,搜索用时 328 毫秒
1.
Matteo Di Giosia Alice Soldà Markus Seeger Andrea Cantelli Fabio Arnesano Maria I. Nardella Vincenzo Mangini Francesco Valle Marco Montalti Francesco Zerbetto Stefania Rapino Matteo Calvaresi Vasilis Ntziachristos 《Advanced functional materials》2021,31(20):2101527
Fullerenes are candidates for theranostic applications because of their high photodynamic activity and intrinsic multimodal imaging contrast. However, fullerenes suffer from low solubility in aqueous media, poor biocompatibility, cell toxicity, and a tendency to aggregate. C70@lysozyme is introduced herein as a novel bioconjugate that is harmless to a cellular environment, yet is also photoactive and has excellent optical and optoacoustic contrast for tracking cellular uptake and intracellular localization. The formation, water-solubility, photoactivity, and unperturbed structure of C70@lysozyme are confirmed using UV-visible and 2D 1H, 15N NMR spectroscopy. The excellent imaging contrast of C70@lysozyme in optoacoustic and third harmonic generation microscopy is exploited to monitor its uptake in HeLa cells and lysosomal trafficking. Last, the photoactivity of C70@lysozyme and its ability to initiate cell death by means of singlet oxygen (1O2) production upon exposure to low levels of white light irradiation is demonstrated. This study introduces C70@lysozyme and other fullerene-protein conjugates as potential candidates for theranostic applications. 相似文献
2.
3.
4.
Markus Bödenler Ludovic de Rochefort P. James Ross Nicolas Chanet Geneviève Guillot Gareth R. Davies 《Molecular physics》2019,117(7-8):832-848
ABSTRACTFast field-cycling (FFC) nuclear magnetic resonance relaxometry is a well-established method to determine the relaxation rates as a function of magnetic field strength. This so-called nuclear magnetic relaxation dispersion gives insight into the underlying molecular dynamics of a wide range of complex systems and has gained interest especially in the characterisation of biological tissues and diseases. The combination of FFC techniques with magnetic resonance imaging (MRI) offers a high potential for new types of image contrast more specific to pathological molecular dynamics. This article reviews the progress in FFC-MRI over the last decade and gives an overview of the hardware systems currently in operation. We discuss limitations and error correction strategies specific to FFC-MRI such as field stability and homogeneity, signal-to-noise ratio, eddy currents and acquisition time. We also report potential applications with impact in biology and medicine. Finally, we discuss the challenges and future applications in transferring the underlying molecular dynamics into novel types of image contrast by exploiting the dispersive properties of biological tissue or MRI contrast agents. 相似文献
5.
Riikka Susitaival Ilmari Juva Markus Peuhkuri Samuli Aalto 《Telecommunication Systems》2006,33(1-3):67-88
In this paper we analyze measurements gathered from a 2.5~Gbps link in the Finnish university network (Funet) in 2004. The
traffic is broken down into origin-destination (OD) pair components based on source and destination IP address. We study the
traffic characteristics of these components, and identify four typical representative OD pairs. For these pairs we investigate
the validity of a moving IID Gaussian model. We find that the statistical properties of these OD pairs differ significantly
from each other, with only some of them close to Gaussian. The OD pairs are also found to have some cross-correlation between
each other, contradicting an often made assumption about OD pair independence. Furthermore, the existence of a mean-variance
relation between the OD pairs is studied. We find that there is a relation between mean and variance, but for some periods
of time it is rather weak. 相似文献
6.
7.
8.
By using a sheaf-theoretical language, we introduce a notion of deformation quantization allowing not only for formal deformation parameters but also for real or complex ones as well. As a model for this approach to deformation quantization, we construct a quantization scheme for cotangent bundles of Riemannian manifolds. Here, we essentially use a complete symbol calculus for pseudodifferential operators on a Riemannian manifold. Depending on a scaling parameter, our quantization scheme corresponds to normally ordered, Weyl or antinormally ordered quantization. Finally, it is shown that our quantization scheme induces a family of pairwise isomorphic strongly closed star products on a cotangent bundle. 相似文献
9.
Markus Szymik 《Topology and its Applications》2007,154(11):2323-2332
Let G be a finite group. For semi-free G-manifolds which are oriented in the sense of Waner [S. Waner, Equivariant RO(G)-graded bordism theories, Topology and its Applications 17 (1984) 1-26], the homotopy classes of G-equivariant maps into a G-sphere are described in terms of their degrees, and the degrees occurring are characterised in terms of congruences. This is first shown to be a stable problem, and then solved using methods of equivariant stable homotopy theory with respect to a semi-free G-universe. 相似文献
10.
G.Biju Kumar Hetal.V Patel Amrish C Shah Markus Trenkle Christine J Cardin 《Tetrahedron: Asymmetry》1996,7(12):3391-3396
N-Arylsulfonamides of (R)- and (S)-2-amino-1-butanol, on condensation with aromatic aldehydes produced diastereomerically pure 2-aryl-3-arenesulfonyl 4-ethyl-1,3-oxazolidines. The absolute configurations of one enantiomeric pair have been determined from two fully refined X-ray structures, supplemented by nmr data. 相似文献