Readily available amino acid building blocks for the synthesis of phosphole-containing peptides

Nucleophilic substitution of a phospholide anion onto protected 3-iodoalanine leads to the formation of an amino acid with an appended phosphole in excellent yield. Manipulation of the protecting groups, leads to building blocks suitable for the synthesis of phosphole-containing polypeptides.     

A 2.7-V 900-MHz/1.9-GHz dual-band transceiver IC for digitalwireless communication

A 2.7-V 900-MHz/1.9-GHz dual-band transceiver IC consisting of receive, transmit, and local oscillator (LO) sections is presented. The transmit section achieves an unwanted sideband suppression of -43 dBc, LO leakage of -59 dBc, and third-order spurious rejection of -70 dBc. The transmit output noise level is -165 dBc/Hz at a 20-MHz offset from the carrier. The on-chip very high-frequency oscillator has a phase-noise level of -106 dBc/Hz at 100-kHz offset when operating at 800 MHz. The receive section has 36 dB of gain with 36 dB of gain range in 12-dB steps. The transceiver IC has been fabricated using a 25-GHz f_t silicon bipolar process and is designed to operate over a supply-voltage range of 2.7-5.0 V     

A low-noise, low-power VCO with automatic amplitude control forwireless applications

Voltage controlled oscillators (VCOs) used in portable wireless communications applications, such as cellular telephony, are required to achieve low phase-noise levels while consuming minimal power. This paper presents the design challenges of a VCO with automatic amplitude control, which operates in the 300 MHz to 1.2 GHz frequency range using different external resonators. The VCO phase noise level is -106 dBc/Hz at 100-KHz offset from an 800-MHz carrier, and it consumes 1.6 mA from a 2.7-V power supply. An extensive phase-noise analysis is employed for this VCO design in order to identify the most important noise sources in the circuit and to find the optimum tradeoff between noise performance and power consumption     

Étude théorique d'une électrode tournante à double annfau: Partie III. Simulation d'un courant constant sur l'anneau interne

Digital simulation treatments supposing constant current flowing suddenly imposed across the internal electrode for two rotating systems, the ring-disk and the double ring, are compared. Results are given for a double ring system.     

Fragments of Arithmetic and true sentences

By a theorem of R. Kaye, J. Paris and C. Dimitracopoulos, the class of the Π_n+1‐sentences true in the standard model is the only (up to deductive equivalence) consistent Π_n+1‐theory which extends the scheme of induction for parameter free Π_n+1‐formulas. Motivated by this result, we present a systematic study of extensions of bounded quantifier complexity of fragments of first‐order Peano Arithmetic. Here, we improve that result and show that this property describes a general phenomenon valid for parameter free schemes. As a consequence, we obtain results on the quantifier complexity, (non)finite axiomatizability and relative strength of schemes for Δ_n+1‐formulas. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)     

Structure-Guided Design of a Group B Streptococcus Type III Synthetic Glycan–Conjugate Vaccine

Identification of glycan functional epitopes is of paramount importance for rational design of glycoconjugate vaccines. We recently mapped the structural epitope of the capsular polysaccharide from type III Group B Streptococcus (GBSIII), a major cause of invasive disease in newborns, by using a dimer fragment (composed of two pentasaccharide repeating units) obtained by depolymerization complexed with a protective mAb. Although reported data had suggested a highly complex epitope contained in a helical structure composed of more than four repeating units, we showed that such dimer conjugated to a carrier protein with a proper glycosylation degree elicited functional antibodies comparably to the full-length conjugated polysaccharide. Here, starting from the X-ray crystallographic structure of the polysaccharide fragment–mAb complex, we synthesized a hexasaccharide comprising exclusively the relevant positions involved in binding. Combining competitive surface plasmon resonance and saturation transfer difference NMR spectroscopy as well as in-silico modeling, we demonstrated that this synthetic glycan was recognized by the mAb similarly to the dimer. The hexasaccharide conjugated to CRM₁₉₇, a mutant of diphtheria toxin, elicited a robust functional immune response that was not inferior to the polysaccharide conjugate, indicating that it may suffice as a vaccine antigen. This is the first evidence of an X-ray crystallography-guided design of a synthetic carbohydrate-based conjugate vaccine.     

Direct Synthesis of Nano‐Ferrierite along the 10‐Ring‐Channel Direction Boosts Their Catalytic Behavior

Ferrierite zeolites with nanosized crystals and external surface areas higher than 250 m² g^?1 have been prepared at relatively low synthesis temperature (120 °C) by means of the collaborative effect of two organic structure directing agents (OSDA). In this way, hierarchical porosity is achieved without the use of post‐synthesis treatments that usually involve leaching of T atoms and solid loss. Adjusting the synthesis conditions it is possible to decrease the crystallite size in the directions of the 8‐ and 10‐ring channels, [010] and [001] respectively, reducing their average pore length to 10–30 nm and increasing the number of pores accessible. The small crystal size of the nano‐ferrierites results in an improved accessibility of reactants to the catalytic active centers and enhanced product diffusion, leading to higher conversion and selectivity with lower deactivation rates for the oligomerization of 1‐pentene into longer‐chain olefins.     

Envelopes,indicators and conservativeness

A well known theorem proved (independently) by J. Paris and H. Friedman states that B Σ_{n +1} (the fragment of Arithmetic given by the collection scheme restricted to Σ_{n +1}‐formulas) is a Π_{n +2}‐conservative extension of I Σ_n (the fragment given by the induction scheme restricted to Σ_n ‐formulas). In this paper, as a continuation of our previous work on collection schemes for Δ_{n +1}(T )‐formulas (see [4]), we study a general version of this theorem and characterize theories T such that T + B Σ_{n +1} is a Π_{n +2}‐conservative extension of T . We prove that this conservativeness property is equivalent to a model‐theoretic property relating Π_n ‐envelopes and Π_n ‐indicators for T . The analysis of Σ_{n +1}‐collection we develop here is also applied to Σ_{n +1}‐induction using Parsons' conservativeness theorem instead of Friedman‐Paris' theorem. As a corollary, our work provides new model‐theoretic proofs of two theorems of R. Kaye, J. Paris and C. Dimitracopoulos (see [8]): B Σ_{n +1} and I Σ_{n +1} are Σ_{n +3}‐conservative extensions of their parameter free versions, B Σ^–_{n +1} and I Σ^–_{n +1}. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)     

Nitrogen atom transfer from iron(IV) nitrido complexes: a dual-nature transition state for atom transfer

The mechanism of nitrogen atom transfer from four-coordinate tris(carbene)borate iron(IV) nitrido complexes to phosphines and phosphites has been investigated. In the absence of limiting steric effects, the rate of nitrogen atom transfer to phosphines increases with decreasing phosphine σ-basicity. This trend has been quantified by a Hammett study with para-substituted triarylphosphines, and is contrary to the expectations of an electrophilic nitrido ligand. On the basis of electronic structure calculations, a dual-nature transition state for nitrogen atom transfer is proposed, in which a key interaction involves the transfer of electron density from the nitrido highest occupied molecular orbital (HOMO) to the phosphine lowest unoccupied molecular orbital (LUMO). Compared to analogous atom transfer reactions from a 5d metal, these results show how the electronic plasticity of a 3d metal results in rapid atom transfer from pseudotetrahedral late metal complexes.