A digital pixel sensor array with programmable dynamic range

This paper presents a digital pixel sensor (DPS) array employing a time domain analogue-to-digital conversion (ADC) technique featuring adaptive dynamic range and programmable pixel response. The digital pixel comprises a photodiode, a voltage comparator, and an 8-bit static memory. The conversion characteristics of the ADC are determined by an array-based digital control circuit, which linearizes the pixel response, and sets the conversion range. The ADC response is adapted to different lighting conditions by setting a single clock frequency. Dynamic range compression was also experimentally demonstrated. This clearly shows the potential of the proposed technique in overcoming the limited dynamic range typically imposed by the number of bits in a DPS. A 64 /spl times/ 64 pixel array prototype was manufactured in a 0.35-/spl mu/m, five-metal, single poly, CMOS process. Measurement results indicate a 100 dB dynamic range, a 41-s mean dark time and an average current of 1.6 /spl mu/A per DPS.     

A feasibility study of X‐ray phase‐contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron

Results are presented of a recent experiment at the Imaging and Medical beamline of the Australian Synchrotron intended to contribute to the implementation of low‐dose high‐sensitivity three‐dimensional mammographic phase‐contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics. The effect of such imaging parameters as X‐ray energy, source size, detector resolution, sample‐to‐detector distance, scanning and data processing strategies in the case of propagation‐based phase‐contrast computed tomography (CT) have been tested, quantified, evaluated and optimized using a plastic phantom simulating relevant breast‐tissue characteristics. Analysis of the data collected using a Hamamatsu CMOS Flat Panel Sensor, with a pixel size of 100 µm, revealed the presence of propagation‐based phase contrast and demonstrated significant improvement of the quality of phase‐contrast CT imaging compared with conventional (absorption‐based) CT, at medically acceptable radiation doses.     

Object-based image similarity computation using inductive learningof contour-segment relations

Describes an efficient and effective image similarity calculation method for object-based image comparison at the level of object classes. It uses probabilistic-prediction voting based on the predicted class distribution of each segment of the contour of an object in an image to determine the class of the object. The C4.5 inductive learning algorithm is used to predict the class distribution of object-contour segments. This method is invariant to rotation, scaling and translation of objects. Experimental results show that the method is effective and efficient. It can be used for object-based image retrieval.     

Novel supervisory channel for fibre optic transmission systems

The provision of a supervisory/service channel on digital transmission systems by direct modulation of the transmitted data bit rate is described. The technique is examined in the context of high bit rate fibre optic system applications and both theoretical as well as practical results are presented.     

Combined Linear and $Delta$-Modulated Switch-Mode PA Supply Modulator for Polar Transmitters

A combined linear and delta-modulated (DeltaM) switch-mode PA supply modulator for polar transmitters in wireless handsets is designed in a 0.25 mum CMOS process. The modulator employs a DeltaM switch-mode DC-DC buck converter to enhance the efficiency of a linear regulator at backed-off supply voltages and powers. The delta-modulator's noise-shaping characteristic, linear regulator's power supply rejection, digital pre-emphasis of the input envelope, and a closed-loop amplitude path from the PA output are simultaneously used to achieve state-of-the-art modulator performance. The presented supply modulator follows the input signal's envelope with 20 dB output dynamic range, maximum efficiency of 75.5% at an output power of 30.8 dBm, and 75 dB SFDR for envelope signals up to 4 MHz occupied RF bandwidth. For a 1625 kb/s 8 PSK RF input signal at 900 MHz, polar modulation of a commercial low-power GSM-900 PA provides 10 dB ACPR improvement.     

Pushing the limit: synthesis, photophysical and DNA binding studies of a NIR-emitting Ru(II)-polypyridyl probe with 'light switch' behaviour

The new Ru(II) polypyridyl complex 1 was synthesised using microwave irradiation from the new polypyridyl ligand 2'DipyTAP', and its photophysical properties, and DNA binding abilities were investigated using various spectroscopic techniques; and 1 was shown to act as a 'NIR molecular light switch' for DNA with an emission window between 680 and 860 nm.     

The EASI project-improving the effectiveness and quality ofimage-guided surgery

In recent years, advances in computer technology and a significant increase in the accuracy of medical imaging have made it possible to develop systems that can assist the clinician in diagnosis, planning, and treatment. This paper deals with an area that is generally referred to as computer-assisted surgery, image-directed surgery, or image-guided surgery. We report the research, development, and clinical validation performed since January 1996 in the European Applications in Surgical Interventions (EASI) project, which is funded by the European Commission in their “4th Framework Telematics Applications for Health” program. The goal of this project is the improvement of the effectiveness and quality of image-guided neurosurgery of the brain and image-guided vascular surgery of abdominal aortic aneurysms, while at the same time reducing patient risks and overall cost. We have developed advanced prototype systems for preoperative surgical planning and intraoperative surgical navigation, and we have extensively clinically validated these systems. The prototype systems and the clinical validation results are described in this paper     

Alkylations of N4‐(4‐Pyridyl)‐3,5‐di(2‐pyridyl)‐1,2,4‐triazole: First Observation of Room‐Temperature Rearrangement of an N4‐Substituted Triazole to the N1 Analogue

Attempts to use alkylation to introduce a positive charge at the nitrogen atom of the 4‐pyridyl ring in the bis(bidentate) triazole ligand N⁴‐(4‐pyridyl)‐3,5‐di(2‐pyridyl)‐1,2,4‐triazole ( pydpt ) were made to ascertain what effect a strongly electron‐withdrawing group would have on the magnetic properties of any subsequent iron(II) complexes. Alkylation of pydpt under relatively mild conditions led in some cases to unexpected rearrangement products. Specifically, when benzyl bromide is used as the alkylating agent, and the reaction is carried out in refluxing acetonitrile, the N⁴ substituent moves to the N¹ position. However, when the same reaction is performed in dichloromethane at room temperature, the rearrangement does not occur and the desired product containing an alkylated N⁴ substituent is obtained. Heating a pure sample of N⁴‐Bzpydpt?Br to reflux in MeCN resulted in clean conversion to N1Bzpydpt.Br . This is consistent with N4‐Bzpydpt.Br being the kinetic product whereas N1Bzpydpt.Br is the thermodynamic product. When methyl iodide is used as the alkylating agent, the N⁴ to N¹ rearrangement occurs even at room temperature, and at reflux pydpt is doubly alkylated. The observation of the lowest reported temperatures for an N⁴ to N¹ rearrangement is due to this particular rearrangement involving nucleophilic aromatic substitution: a possible mechanism for this transformation is suggested.     

Innovative approach to interspan fibre break location in fibre amplifier repeatered communication systems

A proposed modification to the component geometry of a fibre amplifier repeater which allows on on-board cable fault location facility to be incorporated is reported. The measurement technique, based on OTDR, allows cable breaks in the section of optical fibre between two fibre amplifier repeaters to be located.<>