Multifunctional redox catalysts as selective enhancers of oxidative stress

Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.     

Generic continuity of restricted weak upper semi-continuous set-valued mappings

Set-valued mappings from a topological space into subsets of a Banach space which satisfy a restricted form of weak upper semi-continuity, have particularly noteworthy properties. We establish a selection theorem for certain set-valued mappings from a (-) unfavourable topological space into subsets of a Banach space and as a consequence derive the property that restricted weak upper semi-continuous set-valued mappings which satisfy a minimality condition, from a (-) unfavourable topological space into subsets of a Banach space are single-valued and norm upper semi-continuous at the points of a residual subset of their domain.     

Depth-profiling of deuterium in steels: Preparation of calibration standards

The preparation of a set of standards for the calibration of the analysis of deuterium using the²H/³He, p/⁴He reaction is described. Important considerations in the selection of a suitable standard are that it should be stable under irradiation and be simple to prepare with ready control of the amount of analyte. These requirements were met by Ca/OH/₂ which was prepared by the replacement of hydrogen with its isotope in known proportions in the reaction of CaO with water.     

Duality algorithms for nonconvex variational principles

This paper describes, and analyzes, a method of successive approximations for finding critical points of a function which can be written as the difference of two convex functions. The method is based on using a non-convex duality theory. At each iteration one solves a convex, optimization problem. This alternates between the primal and the dual variables. Under very general structural conditions on the problem, we prove that the resulting sequence is a descent sequence, which converges to a critical point of the problem. To illustrate the method, it is applied to some weighted eigenvalue problems, to a problem from astrophysics, and to some semilinear elliptic equations.     

Well‐posedness and approximation of solutions of linear divergence‐form elliptic problems on exterior regions

This paper describes well‐posedness, spectral representations, and approximations of solutions of uniformly elliptic, second‐order, divergence form elliptic boundary value problems on exterior regions U in when N ≥ 3. Inhomogeneous Dirichlet, Neumann, and Robin boundary conditions are treated. These problems are first shown to be well‐posed in the space E¹(U) of finite‐energy functions on U using variational methods. Spectral representations of these solutions involving Steklov eigenfunctions and solutions subject to zero Dirichlet boundary conditions are described. Some approximation results for the A‐harmonic components are obtained. Positivity and comparison results for these solutions are given. Copyright © 2014 John Wiley & Sons, Ltd.     

From trips to telcos — next generation service portals

A number of multi-billion dollar businesses (for example Dell, Amazon, Expedia and Google) have been built on top of Web portals that provide customers with a differentiating experience. How do these portals achieve this, and what lessons can BT learn? In this paper we describe technology that supports the development of portals which extend and improve the customer’s experience of interacting with a company by breaking away from the direct manipulation metaphor. We illustrate the approach with a case study and describe the results of the work we have done in terms of the limitations and capabilities of the approach developed.     

A comparison of T2*-weighted magnitude and phase imaging for measuring the arterial input function in the rat aorta following intravenous injection of gadolinium contrast agent

The arterial input function (AIF) is important for quantitative MR imaging perfusion experiments employing Gd contrast agents. This study compared the accuracy of T(2)*-weighted magnitude and phase imaging for noninvasive measurement of the AIF in the rat aorta. Twenty-eight in vivo experiments were performed involving simultaneous arterial blood sampling and MR imaging following Gd injection. In vitro experiments were also performed to confirm the in vivo results. At 1.89 T and TE=3 ms, the relationship between changes in 1/T(2)* in blood (estimated from MR signal magnitude) and Gd concentration ([Gd]) was measured to be approximately 19 s(-1) mM(-1), while that between phase and [Gd] was approximately 0.19 rad mM(-1). Both of these values are consistent with previously published results. The in vivo phase data had approximately half as much scatter with respect to [Gd] than the in vivo magnitude data (r(2)=.34 vs. r(2)=.17, respectively). This is likely due to the fact that the estimated change in 1/T(2)* is more sensitive than the phase to a variety of factors such as partial volume effects and T(1) weighting. Therefore, this study indicates that phase imaging may be a preferred method for measuring the AIF in the rat aorta compared to T(2)*-weighted magnitude imaging.