InP D-HBT ICs for 40-Gb/s and higher bitrate lightwave transceivers

The combination of device speed (f/sub T/, f/sub max/ > 150 GHz) and breakdown voltage (V/sub bceo/ > 8 V) makes the double heterojunction bipolar InP-based transistor (D-HBT) an attractive technology to implement the most demanding analog functions of 40-Gb/s transceivers. This is illustrated by the performance of a number of analog circuits realized in an InP D-HBT technology with an 1.2- or 1.6-/spl mu/m-wide emitter finger: a low phase noise push-push voltage-controlled oscillator with -7-dBm output power at 146 GHz, a 40-GHz bandwidth and low-jitter 40-Gb/s limiting amplifier, a lumped 40-Gb/s limiting driver amplifier with 4.5-V/sub pp/ differential output swing, a distributed 40-Gb/s driver amplifier with 6-V/sub pp/ differential output swing, and a number of distributed preamplifiers with up to 1.3-THz gain-bandwidth product.     

Enhanced fluorescence from o-phthalaldehyde and fluorescamine fluorophores using Triton and β-cyclodextrin

Mexiletine— and lysine hydrochloride—o-phthalaldehyde and mexiletine hydrochloride—, cysteine—, cysteamine—, homocysteine— and lysine hydrochloride—fluorescamine derivatives were subjected to Triton and β-cyclodextrin enhancement treatments. Of several classical fluorescence-enhancing reagents tested (Triton, β-cyclodextrin, sodium dodecyl sulphate, Brij), Triton provided the best results, followed by β-cyclodextrin. Increases in fluorescence emission by a factor of up to about 10 (mexiletine—fluorescamine—Triton X-100) were observed, with a generally negligible influence of the enhancing reagents on the excitation and emission maxima. Fluorescence enhancement by the addition of a suitable reagent solution to the final analyte solution may, in specific instances, enhance the detectability of native or chemically induced fluorophores.     

Determination of pimozide in oral preparations by spectrofluorometry

The intense native fluorescence of pimozide is reported. It is due to the benzo-1,3-diazolin-2-one fraction of the molecule, also present in the structurally analogous benperidol molecule. The fluorescence intensity is nearly independent of solvent acidity. This substance can be determined in oral preparations by its native fluorescence in diethyl ether (lambda(EXC) = 290 nm. lambda = 319 nm) with a detection limit of 0.01 mug/ml.     

Determination of Aqueous Nickel-Carbonate and Nickel-Oxalate Complexation Constants

An ion-exchange method was used to determine complexation constants for the Ni-oxalate and Ni-carbonate systems in a NaClO₄ background electrolyte. The Ni-oxalate data were interpreted in terms of a single Niox(aq) complex having log K ₁ values for Ni²⁺ + ox^2– Niox(aq) of 3.9 ± 0.1 (I.S. = 0.5 mol-L^–1 p[H] = 7.1) and 4.4 ± 0.1 (I.S. = 0.1 mol-L^–1 p[H] = 8.6) at 22 ± 1C. Specific ion-interaction theory (SIT) was used to obtain log K ₁ = 5.17 ± 0.05 (95% confidence level and = –0.23 ± 0.15) at I.S. = 0. The Ni-carbonate studies were carried out at p[H] values of 7.5, 8.5, and 9.6 in 0.5 mol-L^–1 NaClO₄/NaHCO₃ solutions. The NiCO₃(aq) species was the dominant complex in the [CO₃ ^2–] concentration ranges studied at all three p[H] values. A log K ₁ value for Ni²⁺ + CO₃ ^2– NiCO₃(aq) of 2.9 ± 0.3 was deduced at I.S. = 0.5 mol-L^–1. Extrapolating this value to zero ionic strength using the SIT approach yielded log K ₁ = 4.2 ± 0.3 (95% confidence level and = –0.26 ± 0.04). The data allowed upper bound values for the complexation constants for NiHCO₃ ⁺ and Ni(CO₃)₂ ^2– to be estimated, i.e., log K < 1.4 for Ni²⁺ + HCO₃ ^– NiHCO₃ ⁺, and log K ₂ < 2 for NiCO₃(aq) + CO₃ ^2– Ni(CO₃)₂ ^2–, respectively.     

Chemiluminescence flow injection analysis of 1,3-dichloro-5,5-dimethylhydantoin in swimming pool water

A new chemiluminescence (CL) flow-injection method is proposed for the determination of 1,3-dichloro-5,5-dimethylhydantoin (DDH). The method is based on the chemiluminescent reaction of DDH and luminol-H(2)O(2) in an alkaline medium (pH 12.0-12.5). The concentration of the analyte shows a good linear relationship with the produced luminescence intensity in the range of 3.0x10(-8) to 8.0x10(-6) mol l(-1). The detection limit of the proposed method is 1.0x10(-8) mol l(-1) and the relative standard deviation (R.S.D.) is 4.7% (n=5) at 5.0x10(-7) mol l(-1). This method was successfully applied to the determination of trace amounts of this disinfectant in water samples obtained from five different swimming pools. Satisfying recovery values were also obtained.     

Improvement of cyclosporin A determination in whole blood by reversed-phase high-performance liquid chromatography

A chromatographic method was developed for the determination of cyclosporin A in human whole blood using reversed-phase HPLC at room temperature. Most previous reports carried out this liquid chromatographic separation at temperatures above 70 degrees C. The present procedure greatly improves the detection limit by controlling peak broadening effects, as well as the lifetime of the column at room temperature. Under optimal conditions and using ketoconazole as an internal standard, the calibration graph was linear in the range of 16-1000 microg/L with a relative standard deviation of 3.72% at 150 microg/L and 2.45% at 300 microg/L (n = 11) of cyclosporin A. The detection limit was of 5.0 microg/L cyclosporin A. By this procedure, cyclosporin A pharmacokinetic parameters in healthy Chinese subjects were studied. The developed method could be applied to the quantification of cyclosporin A in human blood samples and allows the study of its pharmacokinetics in routine laboratories.     

A Low-Power Linear SiGe BiCMOS Low-Noise Amplifier for Millimeter-Wave Active Imaging

This letter presents a low-power linear and wideband two-stage millimeter-wave low-noise amplifier (LNA) fabricated in a low-cost 0.18 $mu{rm m}$ SiGe BiCMOS technology. Design techniques utilized to optimize the gain and NF and to achieve high linearity and wideband at W-band are addressed. The LNA achieves a peak power gain of 14.5 dB at 77 GHz with a 3 dB bandwidth of 14.5 GHz from 69 to 83.5 GHz. The measured NF is 6.9 dB at 77 GHz and is lower than 8 dB from 64 to 81 GHz. Both input and output return losses are better than 11 dB and 17 dB at 77 GHz, respectively. The measured input 1 dB compression point is $-$11.4 dBm at 77 GHz with low power consumption of only 37 mW.      

Compact InP-based HBT VCOs with a wide tuning range at W- andD-band

Compact monolithic integrated differential voltage-controlled oscillators (VCOs) operating in W-band were realized using InP-based heterojunction bipolar transistors (HBTs). The oscillators, with a total chip size of 0.6 by 0.35 mm², are based on a balanced Colpitts-type topology with a coplanar transmission-line resonator. By varying the voltage across the base-collector junction of the HBT in the current mirror and by changing the current in the VCO, the oscillation frequency can be tuned between 84 and 106 GHz. At 100 GHz, a differential voltage swing of 400 mV is obtained, which should be sufficient to drive 100 Gb/s digital logic. By combining the balanced outputs of a similar differential VCO in a push-push configuration, a compact source with close to -10 dBm output power and a tuning range between 138 and 150 GHz is obtained     

An InGaAs-InP HBT differential transimpedance amplifier with 47-GHz bandwidth

Return-to-zero differential phase-shift keying applications require a differential amplifier with high bandwidth, high gain, low noise, and good input impedance match. In this paper, we describe an InGaAs-InP heterostructure bipolar transistor differential transimpedance amplifier with high bandwidth of 47 GHz and high gain of 56 dB-/spl Omega/. The input-referred current noise is less than 35 pA//spl radic/Hz over the measurement range up to 40 GHz.