The effects of different noise types and mobility on error rate of digital modulation schemes over millimeter-wave Weibull fading channels

Wireless Networks - Millimeter (mm-wave) communication is a prominent candidate to support the evolution towards fifth generation (5G) wireless systems. As such, in this paper, we study the impact...     

On the application of the sum of generalized Gaussian random variables: maximal ratio combining

In most wireless communication systems, the additive noise is assumed to be Gaussian. However, there are many practical applications where non-Gaussian noise impairs the received signal. Examples include co-channel and adjacent channel interference in mobile cellular systems, impulsive noise in wireless and power-line communications, ultra-wide-band interference and multi-user interference in wireless systems, and spectrum sensing. To cover this issue, we consider in this paper the application of the sum of generalized Gaussian (GG) random variables (RVs). To this end, we consider single-input multiple-output (SIMO) systems that operate over Nakagami-m fading channels in the presence of an additive white generalized Gaussian noise (AWGGN). Specifically, we derive a closed-form expression for the bit error rate (BER) of several coherent digital modulation schemes using maximal ratio combining diversity in the Nakagami-m fading channels subject to an AWGGN. The derived expression is obtained based on the fact that the sum of L GG RVs can be approximated by a single GG RV with a suitable shaping parameter. In addition, the obtained BER expression is valid for integer and non-integer value of the fading parameter m. Analytical results are supported by Monte-Carlo simulations to validate the analysis.     

How significant is the assumption of the uniform channel phase distribution on the performance of spatial multiplexing MIMO system?

Spatial multiplexing (SMX) multiple-input multiple-output (MIMO) systems are promising candidates to enhance the achievable throughput and the overall spectral efficiency in future wireless systems. Performance studies of these systems over different channel conditions assume simplified models for the channel phase distribution. This paper highlights the impact of the channel phase distribution assumption on the performance of SMX MIMO systems. The Nakagami-m and the \(\eta -\mu\) fading channels are considered in this study. In existing literature, performance studies of SMX MIMO systems over Nakagami-m fading channel assume uniform phase distribution. Though, it has been reported recently that the Nakagami-m channel phase distribution is not uniform. In this article, we show that the assumption of the channel phase distribution has a major impact on the performance of SMX MIMO systems. The obtained results demonstrate that the performance of SMX MIMO systems significantly varies with different channel phase distributions. Furthermore, it is shown that uniform assumption of channel phase distribution is incorrect and leads to erroneous conclusions. Detailed performance analysis for more accurate channel models are provided and results are sustained through Monte-Carlo simulations.     

Novel Pomegranate-Nanoparticles Ameliorate Cisplatin-Induced Nephrotoxicity and Improves Cisplatin Anti-Cancer Efficacy in Ehrlich Carcinoma Mice Model

Cisplatin (CISP) is one of the most widely used anti-cancer chemotherapeutic agents with remarkable efficacy against various types of cancers. However, it has been associated with nephrotoxicity amongst other undesirable side effects. Pomegranate (PE) is a potent antioxidant and anti-inflammatory agent effective against cancer, with a superior benefit of not being associated with the common toxicities related to the use of conventional chemotherapeutic agents. However, the application of PE is limited by its reduced solubility and decreased bioavailability. We investigated the potential of a novel nanoparticle (NP) enclosing PE to enhance its solubility and improve its bioavailability, and efficacy to prevent CISP-associated nephrotoxicity in a mice model of Ehrlich solid carcinoma (ESC). All mice were grouped into four cohorts: (I) control, (II) tumor, (III) CISP, and (IV) CISP + PE-NPs. The data obtained demonstrated that PE-NPs was beneficial in potently ameliorating CISP-induced nephrotoxicity in ESC mice. PE-NPs significantly attenuated CISP-induced oxidative stress and lipid peroxidation in the kidney via improving activities of antioxidants (SOD, GSH, and CAT). Additionally, PE-NPs considerably decreased CISP-induced inflammation in the kidney by decreasing the levels of NF-kB, IL-1β, and TNF-α. Notably, PE-NPs did not assuage the antitumor efficacy of CISP as revealed by histological assessment and tumor weight data. In summary, PE-NPs may be a potent alternative anticancer therapy devoid of nephrotoxicity.     

Antibacterial Effects of Commiphora gileadensis Methanolic Extract on Wound Healing

Commiphora gileadensis (CG) is a small tree distributed throughout the Middle East. It was traditionally used in perfumes in countries in this area. In Saudi Arabia, it was used to treat wounds burns and as an antidote to scorpion stings. This study aimed to evaluate the antimicrobial activity and cutaneous wound healing efficiency of the CG extracts using microbiological tests, rate of wound contraction and histopathological changes. CG plant were extracted using the methanol extraction technique; then, the methanolic extract was characterized using liquid chromatography coupled with mass spectrometry (LC–MS). Afterwards, a six-millimetre (mm) excision wound was induced in 60 male Balb/c mice. Mice were classified into two classes; each class consisted of three groups of 10 mice. In the non-infected wound class, the group I was assigned as control and received normal saline. Group II received gentamicin treatment, and group III treated with CG-methanolic extract. In the Staphylococcus aureus-infected class, group IV received normal saline, and groups V and VI were treated with gentamicin and CG-methanolic extract, respectively. The colonization of infected wounds was determined using colony-forming units (CFUs), and the percentage of wound contraction was measured in all groups. Finally, the histopathologic semi-quantitative determination of wound healing was evaluated by inflammatory cell infiltration, the presence of collagen fibres and granulation tissue, and the grade of re-epithelization. Composition analysis of the methanolic extract confirmed the presence of a high amount of ceramide (69%) and, to a lesser extent, hexosylceramide (18%) and phosphatidylethanolamine (7%) of the total amount. Additionally, there was a statistically significant difference between the percentage of wound contraction in the CG-treated and control groups in both Staphylococcus aureus-infected and non-infected wounds (p < 0.01). The colonization of the infected wounds was lower in the group treated with CG than in the control group (p < 0.01). In both non-infected and infected wounds, the CG-treated group showed significant statistical differences in inflammatory cell infiltration, collagen fibres, re-epithelization and granulation tissue formation compared with the control group (p < 0.01). The CG extract possesses antibacterial and anti-inflammatory properties that induce wound healing.     

In Vitro and In Silico Investigation of Diterpenoid Alkaloids Isolated from Delphinium chitralense

This study reports the isolation of three new C₂₀ diterpenoid alkaloids, Chitralinine A–C (1–3) from the aerial parts of Delphinium chitralense. Their structures were established on the basis of latest spectral techniques and single crystal X-rays crystallographic studies of chitralinine A described basic skeleton of these compounds. All the isolated Compounds (1–3) showed strong, competitive type inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in comparison to standard allanzanthane and galanthamine however, chitralinine-C remained the most potent with IC₅₀ value of 11.64 ± 0.08 μM against AChE, and 24.31 ± 0.33 μM against BChE, respectively. The molecular docking reflected a binding free energy of −16.400 K Cal-mol⁻¹ for chitralinine-C, having strong interactions with active site residues, TYR334, ASP72, SER122, and SER200. The overall findings suggest that these new diterpenoid alkaloids could serve as lead drugs against dementia-related diseases including Alzheimer’s disease.     

Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs

Alzheimer’s disease is an emerging health disorder associated with cognitive decline and memory loss. In this study, six curcumin analogs (1a–1f) were synthesized and screened for in vitro cholinesterase inhibitory potential. On the basis of promising results, they were further investigated for in vivo analysis using elevated plus maze (EPM), Y-maze, and novel object recognition (NOR) behavioral models. The binding mode of the synthesized compounds with the active sites of cholinesterases, and the involvement of the cholinergic system in brain hippocampus was determined. The synthesized curcumin analog 1d (p < 0.001, n = 6), and 1c (p < 0.01, n = 6) showed promising results by decreasing retention time in EPM, significantly increasing % SAP in Y-maze, while significantly (p < 0.001) enhancing the % discrimination index (DI) and the time exploring the novel objects in NORT mice behavioral models. A molecular docking study using MOE software was used for validation of the inhibition of cholinesterase(s). It has been indicated from the current research work that the synthesized curcumin analogs enhanced memory functions in mice models and could be used as valuable therapeutic molecules against neurodegenerative disorders. To determine their exact mechanism of action, further studies are suggested.     

Neuroprotective Potential of Synthetic Mono-Carbonyl Curcumin Analogs Assessed by Molecular Docking Studies

Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their promising in vitro anticholinesterase activities, they were further investigated for in vivo neuroprotective and memory enhancing effects in scopolamine-induced amnesia using elevated plus maze (EPM) and novel object recognition (NOR) behavioral mice models. The effects of the synthesized compounds on the cholinergic system involvement in the brain hippocampus and their binding mode in the active site of cholinesterases were also determined. Compound h2 (p < 0.001) and h3 (p < 0.001) significantly inhibited the cholinesterases and reversed the effects of scopolamine by significantly reducing TLT (p < 0.001) in EPM, while (p < 0.001) increased the time exploring the novel object. The % discrimination index (DI) was significantly increased (p < 0.001) in the novel object recognition test. The mechanism of cholinesterase inhibition was further validated through molecular docking study using MOE software. The results obtained from the in vitro, in vivo and ex vivo studies showed that the synthesized curcumin analogs exhibited significantly higher memory-enhancing potential, and h3 could be an effective neuroprotective agent. However, more study is suggested to explore its exact mechanism of action.     

A unified framework for performance evaluation over generalized fading channels

In this paper, we present a unified framework to analyze the performance of the average bit error probability (BEP) and the outage probability over generalized fading channels. Specifically, we assume that the probability density function (PDF) of the instantaneous signal-to-noise ratio \(\zeta \) is given by the product of: power function, exponential function, and the modified Bessel function of the first kind, i.e., \(f_{\zeta }(\zeta )=\zeta ^{\lambda -1}exp\left( -a\zeta ^{\beta }\right) I_{v}\left( b\zeta ^{\beta }\right) \). Based on this PDF, we obtain a novel closed-form expression for the average BEP over such channels perturbed by an additive white generalized Gaussian noise (AWGGN). Note that other well-known noise types can be deduced from the AWGGN as special cases such as Gaussian noise, Laplacian noise, and impulsive noise. Furthermore, we obtain a novel closed-form expression for the outage probability. As an example of such channels, and without loss of generality, we analyze the performance of the average BEP and the outage probability over the \(\eta \)–\(\mu \) fading channels. Analytical results accompanied with Monte-Carlo simulations are provided to validate our analysis.