非均匀应变场中光纤布拉格光栅的数值分析

当非均匀应变场作用在光纤布拉格光栅（FBG）上时,由于FBG周期和有效折射率在沿FBG长度方向都为变量,所以会导致光谱形状的变化。采用耦合模理论和龙格库塔的方法可以准确地分析非均匀应变场中的FBG光谱特性,其缺点是收敛速度慢;而传输矩阵法虽然可以大大提高收敛速度,但是由于忽略了非均匀应变场的变化梯度,在分析变化率较大的非均匀应变场时与龙格-库塔方法相比准确度较差,通过改进适用于分析非均匀应变场的FBG等效周期,既保留了传输矩阵分析FBG的快速收敛性,又保证了分析准确性。     

Tagged molecule induced nanoparticle aggregation： Raman reporter-labeled immuno-Au aggregate as immuno-sensor

<正>A novel structure with high surface enhanced Raman scattering(SERS) activity and bio-specificity as a SERS-based immuno-sensor(named as Raman reporter-labeled immuno-Au aggregate) is demonstrated and employed for protein detection.In each fabrication process,the features of those aggregates are obtained and characterized by ultraviolet-visible(UV-Vis) extinction spectra,transmission electron microscopy (TEM) images,scanning electron microscopy(SEM) pictures,and SERS spectra.Experimental results indicate that proper amounts of the reporter molecules can result in the moderate aggregation morphologies of gold nanoparticles.Compared with the previously reported method using Raman reporterlabeled immuno-Au nanoparticles,more sensitive SERS-based protein detection is realized with this novel immuno-sensor.     

基于光纤光栅的简支矩形板挠度和应变测量方法

提出一种利用光纤光栅传感器测量简支矩形薄板在横向载荷下挠度和应变分布的一种方法.通过在薄板4个不同位置各埋设1根光纤光栅,利用基于可调谐激光原理的光纤光栅传感解调系统检测出应变信息,并结合简支矩形板纳维叶解的前4项计算出决定挠度和应变的必要参数,最终代入矩形板各位置的坐标值即可获得矩形板各点的挠度和应变值.实验采用集中应力的方式对矩形板进行了载荷实验,实验结果与理论模拟相符,证实了该方法的可行性.     

二次谐波细胞成像的研究进展

由于二次谐波(Second harmonic generation, SHG)技术具有探测深度深,对生物体的损伤小,时间空间分辨率高以及对结构的对称性敏感等特性,SHG成像成为近年来生物成像领域的研究热点.介绍了SHG成像技术的原理及其在细胞成像中的应用,重点介绍了基于染料标记的成像技术,特别是利用电压敏感染料,手性材料和金属纳米粒子作为标记的几种SHG细胞成像技术,最后展望了该技术在生物成像领域的应用前景.     

光纤布拉格光栅法布里-珀罗腔纵模特性研究

分析了光纤布拉格光栅构成的法布里-珀罗（F-P）腔的透射谱特性，讨论了光栅带宽，反射系数相位因子以及腔长对F-P腔透射特性的影响，并对F-P腔随温度和应变的特性进行了分析，然后给出如何设计在光栅中心耦合波长处单模运转的法布里-珀罗腔.并提供了数值模拟结果和实验结果. 关键词： 光纤布拉格光栅 法布里-珀罗（F-P）腔 光纤激光器     

Wide-band double-pass discrete Raman amplifier with reflection of signals and pumps

A wide-band (1530-1610 nm) and high efficient double-pass discrete Raman amplifier is reported. In this Raman amplifier, by using a one-end gilded fiber as the broadband reflector, signals and multi-pump are both reflected to propagate through the gain fiber for a second time. An increase in net gain of more than 150% has been achieved compared with that in the typical co-pumped Raman amplifier. The advantages of this proposed new configuration have been experimentally studied by comparing with the recently existing Raman amplifier configurations.     

Biocompatible and stable core/shell drug nanocarrier with high surface-enhanced Raman scattering activity

<正>A novel drug carrier based on SiO_2-coated silver nanoparticle aggregates and antitumor drug is successfully synthesized.The surface-enhanced Raman scattering(SERS) spectra of the antitumor drug in living cells are obtained.By using silver nano-aggregates as SERS substrates instead of dispersed silver particles, a great improvement of SERS signal intensity is achieved.It is found that the chemical stability of the drug carrier can also be increased with the existence of SiO_2 shell.The adsorbing effect between antitumor drug 9-aminoacridine(9AA) and silver particles is investigated to optimize the SERS signal. The core/shell structure of the drug carrier is characterized by ultraviolet-visible(UV-Vis) spectroscopy and transmission electron microscopy(TEM) pictures.The experimental results show that the drug carrier offers biocompatibility,stability,and high SERS activity,holding the potential for realizing the intracellular drug tracing.     

“金属-有机物-金属”三明治型表面增强拉曼散射探针的制备及在免疫检测中的应用

制备了二氧化硅包裹的具有“金属-有机物-金属”三明治结构的表面增强拉曼散射( SERS)光学免疫检测探针,研究了探针的形貌、结构、组分等多种因素对其SERS特性的影响,探索出具有较好SERS活性的制备参数。之后利用探针上集成的SERS信号,采用三明治免疫法,实现了激酶抑制因子( p21)和人体抑癌基因( p53)两种疾病因子的高特异性检测。     

基于金纳米聚集体的核壳型SERS探针及其细胞内应用

利用金纳米粒子的聚集体作为表面增强拉曼散射（Surface enhanced Raman scattering,SERS）的增强基底,合成了一种二氧化硅包裹的核壳型SERS探针,并成功将该探针应用于活细胞的SERS光谱探测.实验中利用4-巯基苯甲酸（4-mercaptobenzoicacid,4MBA）作为拉曼标记物,...     

Wide-band double-pass discrete Raman amplifier with reflection of signals and pumps

A wide-band(1530-1610 nm)and high efficient double-pass discrete Raman amplifier is reported.In this Raman amplifier,by using a one-end gilded fiber as the broadband reflector,signals and multi-pump are both reflected to propagate through the gain fiber for a second time.An increase in net gain of more than 150% has been achieved compared with that in the typical co-pumped Raman amplifier.The advantages of this proposed new configuration have been experimentally studied by comparing with the recently existing Raman amplifier configurations.