案例1:HCD1328(118)TSD线路板短路漏电的原因

一、样品描述 所送样品为型号为HCD1328(118)TSD的线路板,该批板有不同程度的短路漏电现象,而与之配套的显示板和芯片内依线显示正常,今委托单位要求分析该板短路漏电的原因。     

减少脱胶工序

东莞新科于1989年建厂以来，产品从电脑软驱磁头到硬盘合成磁头、薄膜磁头、磁阻MR磁头到现在的巨磁阻GMR磁头不断更新升级。现在新科已成为：全球最大的磁记录产品原厂委托制造商(OEM)之一。而我们部门专为美国奥美加公司生产ZIP系列驱动器的电脑磁头，作为最前面的磁座制作工场，其产品微小、控制规格精密加工步骤多，需要多次换夹。因此有许多的辅助工序，其中的五道脱胶工序不但耗时久，而且使前后工序待料时间长，因此圈员们一致认为这是效率改善的一个突破口．     

网络优化的后台分析技术

随着移动通信的日益普及，广大用户对网络质量的要求越来越高，为了满足用户对网络质量要求的不断提高，必须要加强网络优化工作，提高网络优化水平。网络优化的主要手段有路面测试、室内测试、投诉分析等前台方法，以及话统分析、性能分析、计算机仿真等后台方法，在实践中发现，这些手段一方面存在耗费人力，时间以及修正模型困难等麻烦，另一方面由于方法的局限性导致网络优化与市场分析，客户服务等专业结合不紧密，大量有价值的信息没有得到充分利用，从而不能在根本上改善网络质量，满足用户需求。[编者按]     

Method development for the quantitation of ABT-578 in rabbit artery tissue by 96-well liquid-liquid extraction and liquid chromatography/tandem mass spectrometric detection

Quantitative determination of drug concentrations in tissue samples can provide critical information for drug metabolism, kinetics, and toxicity evaluations. For analysis of tissue samples using liquid chromatography/tandem mass spectrometric (LC/MS/MS) detection, homogenization is a critical step in achieving good assay performance. Assay performance can be closely evaluated by spiking the drug directly into tissue samples prior to homogenization. It is especially important to include this assay evaluation for the analysis of artery tissue samples because artery tissue is very elastic, making it quite a challenge to develop an effective procedure for homogenization. An LC/MS/MS assay in 96-well format using liquid-liquid extraction was developed for analyzing ABT-578 in rabbit artery samples. Tissue quality control samples were prepared by spiking ABT-578 stock solutions directly into the tissue before homogenization. The usage of the tissue control samples gives a thorough evaluation of the sample preparation process that includes both homogenization and sample extraction. A 20% blood in saline solution was used as a homogenization solution. Calibration standards were made by spiking ABT-578 into rabbit whole blood. Blood quality control samples were also prepared by spiking ABT-578 into rabbit whole blood. These blood QC samples were used to confirm the validity of the calibration curve. A lower limit of quantitation of 0.050 ng/mL was achieved. The linear dynamic range of blood standards was from 0.050-30.3 ng/mL with the correlation coefficient (r) ranging from 0.9969-0.9996. Overall %CV was between 1.3 and 7.0%, and analytical recovery was between 98.2 and 105.8% for blood QC samples. The %CVs for tissue QC samples were between 6.7 and 13.0%, and analytical recovery after correction was between 93.5 and 114.3%.     

A light-driven rotaxane molecular shuttle with dual fluorescence addresses

[reaction: see text] A molecular shuttle containing an alpha-CD macrocycle, an azobenzene unit, and two different fluorescent naphthalimide units was synthesized. The cis-trans photoisomerization of the azobenzene unit resulted in the motion of the CD macrocycle on the track. Because of the easy regulation and full reversibility of the fluorescence change of the two stopper units, the molecular shuttle could be used as a molecular storage medium or switch with all-optical inputs and outputs.     

我国古代的炭黑生产及法家科学家的贡献

炭黑是现代石油化工重要产品之一。我们伟大的祖国,是世界上生产炭黑最早的国家。远在原始公社时期,我们的祖先在长期的生产实践中已掌握了在不完全燃烧的情况下产生炭黑(烟炱)的操作技术,用来熏染陶坯,生产精美的黑陶。炭黑生产技术的发展,与我国古代文字的产生、纸的发明及印刷术的发展等辉煌成就有着密切的联系。上古时期制墨,以天然石墨为主,后来就被更为优越的松烟炭黑所代替。汉朝时曾有过许多关于墨的记载。公元100年出版的我国最早的一本字典《说文     

Identification of differentially expressed proteins between human hepatoma and normal liver cell lines by two-dimensional electrophoresis and liquid chromatography-ion trap mass spectrometry

In the previous study, the proteomes of the human hepatoma cell line BEL-7404 and the normal human liver cell line L-02 were separated by high resolution two-dimensional electrophoresis (2-DE). Image analysis revealed that 99 protein spots showed quantitative and qualitative variations that were significant (P < 0.01) and reproducible. Here we report the identification results of some of these protein spots. Protein spots excised from 2-D gels were subjected to in-gel digestion with trypsin, and the resulting peptides were measured by microbore high performance liquid chromatography - ion trap - mass spectrometry (LC-IT-MS) to obtain the tandem mass (MS/MS) spectra. Twelve protein spots were identified with high confidence using SEQUEST with uninterpreted MS/MS raw data. Besides inosine-5'-monophosphate dehydrogenase 2, heat shock 27 kDa protein, calreticulin and calmodulin, whose expression was elevated in hepatoma cells, glutathione-S-transferase P was identified from hepatoma cells in which its level was 18-fold higher compared to human liver cells. Two spots were identified as the homologs of reticulocalbin for the first time in hepatoma cells and their expression increased compared to liver cells. However, tubulin beta-1 chain and natural killer cell enhancing factor B were downregulated in hepatoma cells. A tumor suppressing serpin, maspin precursor, was identified from one spot whose quantity was much higher in the normal liver cell line. More interestingly, epidermal fatty acid-binding protein (E-FABP) and fatty acid-binding protein, adipocyte-type (A-FABP), were detected in liver cells but not in hepatoma cells. The functional implication of the identified proteins was discussed.