胰岛素样生长因子-1对血管平滑肌细胞PI3K／PTEN信号通路的影响

目的：探讨胰岛素样生长因子-1(IGF-1)促血管平滑肌细胞(VSMC)增殖的细胞内信号转导机制。方法：体外培养的兔血管平滑肌细胞分3组处理，以细胞计数、噻唑盐比色法测定细胞增殖能力，以磷脂酰肌醇-3激酶(PI3K)特异性抑制剂渥漫青霉素(WT)孵育细胞间接反映PI3K作用。Western Blot定量磷酸酶PTEN表达水平，免疫沉淀、特异底物diC16PIP3绿色试剂法测定PTEN脂质磷酸酶活性。结果：IGF-1(100μg／L)使细胞计数及MTT比色A值分别增加至对照组的2．8倍和3．8倍，WT抑制VSMC增殖，并完全逆转IGF-1的作用(均P<0.01)。各浓度IGF-1对PTEN蛋白表达水平无明显影响，其对PTEN活性的抑制呈浓度(10～100μg／L)及时间(3min～24h)依赖性(均P<0．01)。结论：IGF-I促VSMC增殖作用与活化PI3K蛋白激酶的促生长活性及抑制PTEN脂质磷酸酶的负性调节细胞生长作用有关。     

Si基Sr1.8Ca0.2NaNb5O15薄膜的合成及光学特性研究

利用溶胶-凝胶法,在Si(001)单晶衬底上逐层生长四方钨青铜结构的Sr1.8Ca0.2NaNb5O15(SCNN)薄膜。利用X射线衍射(XRD)仪、扫描电子显微镜(SEM)和原子力显微镜(AFM)等技术研究了薄膜的微结构,结果表明,SCNN薄膜在厚度较小的状态下可呈现出明显的(001)择优取向,而随着厚度的增加择优取向受到抑制,颗粒尺寸增大,薄膜的多晶态的趋势增强。然后通过测量薄膜在400~780nm光谱范围内的反射率曲线,采用Sellmeier色散公式分析折射率非均匀性的影响,通过改进的单纯形法计算拟合出SCNN薄膜的折射率和厚度,其中厚度的结果利用SEM加以验证,而折射率的变化则与薄膜结晶态的变化保持一致。     

基于马赫-曾德尔干涉仪的可调谐掺镱光纤激光器

A ring-shaped all fiber tunable Yb-doped fiber laser with tuning range over 20 nm is demonstrated by using a fiber Mach-Zenhder interferometer as an intra-cavity filter which is constructed with two 3-dB optical couplers. The method for fabricating the fiber Mach-Zenhder interferometer is detailed. The fiber laser has a moderate milli-Watt level output power over the whole tuning range from 1050 to 1071 nm, a side-band suppression ratio greater than 45 dB, and a bandwidth less than 0.1 nm.     

Fiber laser-pumped, chirped, PPMgLN-based high efficient broadband mid-IR generation

We demonstrate a high-efficiency, high-power-nanosecond fiber laser-pumped broadband mid-infrared out- put based on a linearly chirped PPMgLN crystal. By using a linearly polarized pulsed Yb-doped fiber laser as the pump, we experimentally obtain a 1.22-W broadband mid-infrared laser output under pump power of 10.15 W. The 3-dB bandwidths of the idler and signal output are approxiwately 150 and 13 nm, centering at 3.60 and 1.51 μm, respectively. The measured idler spectrum shows a smooth spectral profile.     

Isoscalar Giant Monopole Resonance in Relativistic Continuum Random Phase Approximation

The isoscalar giant monopole resonance （ISGMR） in nuclei is studied in the framework of a fully consistent relativistic continuum random phase approximation （RCRPA）. In this method the contribution of the continuum spectrum to nuclear excitations is treated exactly by the single particle Green＇s function technique. The negative energy states in the Dirac sea are also included in the single particle Green＇s function in the no-sea approximation. The single particle Green＇s function is calculated numerically by a proper product of the regular and irregular solutions of the Dirac equation. The strength distributions in the RCRPA calculations, the inverse energyweighted sum rule m-1 and the centroid energy of the ISGMR in ^120Sn and ^208Pb are analysed. Numerical results of the RCRPA are checked with the constrained relativistic mean field model and relativistic random phase approximation with a discretized spectrum in the continuum. Good agreement between them is achieved.     

一种基于增益调制技术的全光纤化脉冲Yb光纤激光器

以波长为975 nm的半导体激光器作为泵浦源,周期性地脉冲泵浦一个包含Yb掺杂光纤和光纤光栅对的Yb光纤激光器,实现了基于增益调制技术的全光纤化高功率Yb光纤激光器的稳定脉冲输出.在50 kHz重频下,采用20 W的泵浦功率和2.4 μs的泵浦脉冲宽度,获得了1 060 nm波长脉冲宽度仅100 ns的稳定脉冲激光输出,单脉冲激光能量约为20 μJ.以此作为脉冲激光种子进行功率放大,获得了性能稳定的全光纤结构高功率脉冲激光输出,放大后单脉冲能量超过200 μJ,激光放大器斜率效率达到60%.     

Collective multipole excitations of exotic nuclei in relativistic continuum random phase approximation

The isoscalar and isovector collective multipole excitations in exotic nuclei are studied in the framework of a fully self-consistent relativistic continuum random phase approximation （RCRPA）. In this method the contri- bution of the continuum spectrum to nuclear excitations is treated exactly by the single particle Green＇s function. Different from the cases in stable nuclei, there are strong low-energy excitations in neutron-rich nuclei and proton-rich nuclei. The neutron or proton excess pushes the centroid of the strength function to lower energies and increases the fragmentation of the strength distribution. The effect of treating the contribution of continuum exactly is also discussed.     

Relativistic Continuum Random Phase Approximation and Applications I. Formalism

A fully consistent relativistic continuum random phase approximation （RCRPA） is constructed in terms of the Green＇s function technique. In this method the contribution of the continuum spectrum to nuclear excitations is treated exactly by the single particle Green＇s function, which includes also the negative states in the Dirac sea in the no sea approximation. The theoretical formalism of RCRPA and numerical details are presented. The single particle Green＇s function is calculated numerically by a proper product of regular and irregular solutions of the Dirac equation. The numerical details and the formalism of RCRPA in the momentum representation are presented.     

基于MOPA结构的高功率线偏振脉冲Yb光纤激光器

介绍了基于Nd3+:GdVO_4声光调Q激光器种子源和大直径Yb双包层保偏光纤作为放大介质的高功率线偏振脉冲光纤激光器.一个工作波长为808 nm的半导体激光器端面泵浦的、声光调Q的Nd3+:GdVO_4激光器输出重频在20～50 kHz、平均功率约3 w的高光束质量的1063 nm波长的激光,经过光学耦合系统和光学隔离器进入大直径Yb双包层保偏光纤作为光纤放大器的种子源,在波长为975 nm的半导体激光器泵浦下,光纤放大器获得了近衍射极限的、平均功率超过20 w、偏振抑制比超过14 dB的高功率线偏振脉冲激光输出.