全文获取类型
收费全文 | 460篇 |
免费 | 16篇 |
专业分类
化学 | 286篇 |
力学 | 3篇 |
数学 | 36篇 |
物理学 | 151篇 |
出版年
2023年 | 4篇 |
2022年 | 3篇 |
2021年 | 5篇 |
2019年 | 5篇 |
2018年 | 3篇 |
2017年 | 6篇 |
2016年 | 15篇 |
2015年 | 12篇 |
2014年 | 7篇 |
2013年 | 20篇 |
2012年 | 15篇 |
2011年 | 22篇 |
2010年 | 15篇 |
2009年 | 11篇 |
2008年 | 17篇 |
2007年 | 26篇 |
2006年 | 12篇 |
2005年 | 16篇 |
2004年 | 4篇 |
2003年 | 12篇 |
2002年 | 7篇 |
2001年 | 15篇 |
2000年 | 9篇 |
1999年 | 7篇 |
1998年 | 6篇 |
1997年 | 13篇 |
1996年 | 4篇 |
1995年 | 9篇 |
1994年 | 5篇 |
1993年 | 9篇 |
1992年 | 10篇 |
1991年 | 10篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1986年 | 10篇 |
1985年 | 4篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 16篇 |
1980年 | 3篇 |
1976年 | 3篇 |
1972年 | 3篇 |
1971年 | 5篇 |
1970年 | 3篇 |
1930年 | 4篇 |
1923年 | 3篇 |
1874年 | 2篇 |
排序方式: 共有476条查询结果,搜索用时 31 毫秒
1.
Henry Dring David Kreutzer Christoph Ritter Andreas Hilgeroth 《Molecules (Basel, Switzerland)》2021,26(1)
Despite the development of targeted therapies in cancer, the problem of multidrug resistance (MDR) is still unsolved. Most patients with metastatic cancer die from MDR. Transmembrane efflux pumps as the main cause of MDR have been addressed by developed inhibitors, but early inhibitors of the most prominent and longest known efflux pump P-glycoprotein (P-gp) were disappointing. Those inhibitors have been used without knowledge about the expression of P-gp by the treated tumor. Therefore the use of inhibitors of transmembrane efflux pumps in clinical settings is reconsidered as a promising strategy in the case of the respective efflux pump expression. We discovered novel symmetric inhibitors of the symmetric efflux pump MRP4 encoded by the ABCC4 gene. MRP4 is involved in many kinds of cancer with resistance to anticancer drugs. All compounds showed better activities than the best known MRP4 inhibitor MK571 in an MRP4-overexpressing cell line assay, and the activities could be related to the various substitution patterns of aromatic residues within the symmetric molecular framework. One of the best compounds was demonstrated to overcome the MRP4-mediated resistance in the cell line model to restore the anticancer drug sensitivity as a proof of concept. 相似文献
2.
3.
4.
5.
6.
H. Prade J. Döring W. Enghardt L. Funke L. Käubler 《Zeitschrift für Physik A Hadrons and Nuclei》1987,328(4):501-502
An (α, 2nγ) in-beam study of excited states in 142Nd revealed 27 new levels on top of the 6+ isomer. Nanosecond lifetimes were found for two levels. The measured excitation energies were compared with spherical shell-model predictions obtained from suitably truncated model spaces. 相似文献
7.
Extraction of 3d-Metal Ions by Bidendate Sulfonamides. I. Ligands with Sulfur or Heterocyclic Nitrogen as a Second Donor Atom The properties of 2-acetylpyridine-p-toluensulfonylhydrazone (APSH - H), arensulfonylthioureas (I), and the esters of arensulfonylmonothiocarbamic acid (II) or arensulfonyldithiocarbamic acid (III) as extractants for the late 3d-metal ions are proved. APSH-H is comparable to the proprietary extractant LIX 34. But, because of the special structure of the corresponding 1,2-chelates, the pH1/2-values of nickel(II) and cobalt(II) are ≈2 units lower. The pKs-values, measured in dioxane-water mixtures (75 per cent v/v), increase in the order III < II < I. In aqueous solutions compounds of type III are acids of medium strength. In the case of compounds of type I the substituents of the non-sulfonated nitrogen have a strong influence on the pKs-values (ΔpKs = 4.6). Among the late 3d-elements, the ligands II and III extract only copper(II) (pH1/2 ~2.7 or ~1.6), the ligands I extract zinc(II), cobalt(II), and nickel(II) as well, but not iron(II) and iron(III). The reasons of this unique behaviour are discussed. 相似文献
8.
New Redox Series Based on Transition Metal Complexes of Heterocyclic Arenesulfonylhydrazones Heterocyclic bidentate arenesulfonylhydrazones (2-acetylpyridine-p-toluenesulfonylhydrazone ? APSH? H, 2-acetylquinoline-p-toluenesulfonylhydrazone ? ACSH? H) with transition metal ions afford tetrahedral 1,2-complexes MII(APSH)2 and MII(ACSH)2. In most cases the E-isomers of APSH? and ACSH? are coordinated, five-membered chelate rings are formed with the pyridine and hydrazone nitrogen atoms as donor atoms. In the complexes Zn(APSH)2 and Cu(APSH)2 probably the Z-isomer of APSH? is present with the pyridine and the sulfonylamide nitrogen atoms as a donor set, yielding a six-membered chelate ring. These proposals are based on the magnetic moments, the ligand field spectra, and the binding energies (ESCA). Normally the complexes MII(APSH)2 and MII(ACSH)2 are reduced in two reversible steps. For Fe(APSH)2 and Fe(ACSH)2 a third anodic wave, but for Cu(APSH)2 only one wave is observed. Relations between redox properties and structure of the new complexes are discussed, and the redox series are compared with that of the M(dipy)3n+-type complexes. 相似文献
9.
10.
In a comparative study the in vitro corrosion behavior of a selection of nickel- and cobalt-based alloys for application in
dentistry containing no noble metals was studied with slow scan cyclic voltammetry. The obtained breakthrough potentials,
the repassivation behavior and further typical features of the cyclic voltamograms are correlated with the chemical composition
as measured with electron beam microanalysis. Surface inhomogenities detected with the latter method are discussed with respect
to the electrochemical behavior. For all alloys stabilities in terms of breakthrough potential superior to previously reported
data for nickel-base alloys are found. 相似文献